Results 1 to 10 of about 44,623 (260)

Autophagy Protects Against Eosinophil Cytolysis and Release of DNA

open access: yesCells, 2022
The presence of eosinophils in the airway is associated with asthma severity and risk of exacerbations. Eosinophils deposit their damaging products in airway tissue, likely by degranulation and cytolysis.
Stephane Esnault   +2 more
exaly   +4 more sources

Modulation of Reoviral Cytolysis (II): Cellular Stemness

open access: yesViruses, 2023
Oncolytic viruses (OVs) are an emerging cancer therapeutic that are intended to act by selectively targeting and lysing cancerous cells and by stimulating anti-tumour immune responses, while leaving normal cells mainly unaffected.
Tarryn Bourhill   +5 more
doaj   +2 more sources

Mechanisms of Eosinophil Degranulation [PDF]

open access: yesCells
Eosinophils are highly granulated white blood and tissue cells that play complex roles in the immune system including host protection against helminthic parasites, viruses, fungi, and bacteria.
Sarah Almas, Paige Lacy
doaj   +2 more sources

THE SIGNIFICANCE OF CYTOLYSIS SYNDROME IN CHILDREN [PDF]

open access: yesRomanian Journal of Pediatrics, 2013
The measurement of aminotransferases levels has become part of the routine biochemical tests done in children regardless of their clinical symptoms. Aminotransferases (ALT, AST) are tissue necrosis markers which change in both hepatic and extra-hepatic ...
Laura Mihaela Trandafir   +4 more
doaj   +2 more sources

Eosinophil Extracellular Traps in Health and Disease: From Host Defense to Chronic Inflammation [PDF]

open access: yesBiomedicines
Eosinophils are tissue-adapted granulocytes with important roles in host defense, immune regulation, barrier responses, and inflammatory disease. Beyond classical degranulation, activated eosinophils can release eosinophil extracellular traps (EETs ...
Bojan Stojanovic   +5 more
doaj   +2 more sources

Further Insight into the Mechanism of Human PMN Lysis following Phagocytosis of Staphylococcus aureus

open access: yesMicrobiology Spectrum, 2021
Staphylococcus aureus is an important human pathogen that can cause a variety of diseases ranging from mild superficial skin infections to life-threatening conditions like necrotizing pneumonia, endocarditis, and septicemia. Polymorphonuclear leukocytes (
Viktoria Rungelrath   +8 more
doaj   +1 more source

Biomedical Relevance of Novel Anticancer Peptides in the Sensitive Treatment of Cancer

open access: yesBiomolecules, 2021
The global increase in cancer mortality and economic losses necessitates the cautious quest for therapeutic agents with compensatory advantages over conventional therapies.
Olalekan Olanrewaju Bakare   +5 more
doaj   +1 more source

Laboratory-biochemical features of the course of chronic hepatitis C with polymorphism rs11536889 + 3725G/C of TLR-4 gene

open access: yesJournal of Education, Health and Sport, 2020
Chronic HCV infection remains as a global health problem due to its wide prevalence, latent course without clinical manifestations, development of liver fibrosis with the eventual formation of cirrhosis and liver cancer, which largely leads to poor ...
T. I. Bevz   +3 more
doaj   +1 more source

MDA-MB-231 Breast Cancer Cells Resistant to Pleurocidin-Family Lytic Peptides Are Chemosensitive and Exhibit Reduced Tumor-Forming Capacity

open access: yesBiomolecules, 2020
Direct-acting anticancer (DAA) peptides are cytolytic peptides that show promise as novel anticancer agents. DAA peptides bind to anionic molecules that are abundant on cancer cells relative to normal healthy cells, which results in preferential killing ...
Ashley L. Hilchie   +5 more
doaj   +1 more source

Changes in the blood coagulation system that determine postoperative complications in patients with non-tumor mechanical jaundice

open access: yesВестник хирургии имени И.И. Грекова, 2021
The OBJECTIVE was to study the features of changes in the blood coagulation system that contribute to the development of postoperative complications in patients depending on the stage of non-tumor mechanical jaundice at admission.METHODS AND MATERIALS. A
V. E. Fedorov   +4 more
doaj   +1 more source

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