Results 1 to 10 of about 288,657 (306)

In vitro comparison of antioxidant, cytotoxic, and antibacterial (against Aggregatibacter actinomycetemcomitans) effects of Citrus reticulata, Olea europaea extracts, and essential oils

Dental Research Journal
Background: This study compared the antioxidant, cytotoxic, and antibacterial effects of Citrus reticulata (C. reticulata) peel and Olea europaea (O. europaea) leaf hydroalcoholic extracts and essential oils. Materials and Methods: In this in vitro study,
Surena Vahabi, Maryam Torshabi, Seyedeh Zahra Mirsharif   +2 more
doaj   +1 more source

Cytokine Modulation of Adhesion Molecules in the Regulation of Immunologic Cytotoxicity of Epidermal Targets

Journal of Investigative Dermatology, 1990
Immunologic cytotoxicity is an important endpoint of the immune response to tumors, viral infected cells, grafted tissues, and exogenous microorganisms, and is also an important mechanism of disease, especially in autoimmunity. There are multiple mechanisms of immunologic cytotoxicity, but each has three major stages: leukocyte/target attachment ...
openaire   +2 more sources

Immunologic Cytotoxicity in Alopecia Areata: Apoptosis of Dermal Papilla Cells in Alopecia Areata

Journal of Investigative Dermatology, 1995
medium, i.e., that in which confluent dermal papilla cells had been grown for 48 h, was tested for growth-promoting activity on a human skin keratinocyte cell line using an MTT assay. Normal dermal papilla cell medium stimulated keratinocyte growth signif­ icandy at low concentrations compared to control non-conditioned medium but alopecia areata cell ...
Nortis, David A., Duke, Richard, Whang, Kyu, Middleton, Marjorie   +3 more
openaire   +2 more sources

Single-cell RNA sequencing uncovers heterogenous immune cell responses upon exposure to food additive (E171) titanium dioxide

Journal of Nanobiotechnology
The prospective use of food additive titanium dioxide (E171 TiO2) in a variety of fields (food, pharmaceutics, and cosmetics) prompts proper cellular cytotoxicity and transcriptomic assessment.
Haribalan Perumalsamy, Xiao Xiao, Hyoung-Yun Han, Jung-Hwa Oh, Seokjoo Yoon, Min Beom Heo, Tae Geol Lee, Hyun-Yi Kim, Tae-Hyun Yoon   +8 more
doaj   +1 more source

Epitope-level analysis of cross-reactive human HLA antibodies against genetically modified swine leukocyte antigens in xenotransplantation

Frontiers in Immunology
IntroductionXenotransplantation using genetically modified pigs is a promising solution to organ shortages, particularly for highly sensitized patients with broad anti-HLA sensitization who lack compatible allografts.
Sang-Ik Cho, Ji-Jing Yan, Beom Seok Kim, Beom Seok Kim, Nayoung Ko, Joohyun Shim, Hyunil Kim, Eun-Jee Oh, Eun-Jee Oh   +8 more
doaj   +1 more source

Paclitaxel Modulates the Proliferation and Differentiation of THP-1 Cells Exposed to Inactivated SARS-CoV-2 Virus

Revista Brasileira de Cancerologia
Introduction: Cancer patients were considered a high-risk group for COVID-19. Studies indicate that certain types of cancer, as breast cancer, may exhibit distinct immunological responses.
Everaldo Hertz, Bárbara Osmarin Turra, Nathália Cardoso de Afonso Bonotto, Fernanda dos Santos Trombini, João Arthur Bittencourt Zimmermann, Cibele Ferreira Teixeira, Verônica Farina Azzolin, Ivo Emilio da Cruz Jung, Ivana Beatrice Mânica da Cruz, Fernanda Barbisan   +9 more
doaj   +1 more source

Natural killer cell granule protein 7 contributes to CD8+ T cell-mediated platelet apoptosis in immune thrombocytopenia

Research and Practice in Thrombosis and Haemostasis
Background: CD8+ T cells participate in the pathogenesis of primary immune thrombocytopenia (ITP). Natural killer cell granule protein 7 (NKG7) is essential for natural killer cell and CD8+ T cell cytotoxicity. The function of NKG7 in CD8+ T cells in ITP
Xiaolin Wang, Qiang Liu, Xiaojing Li, Wei Xing, Ping Chen, Qi Feng, Ming Hou, Qian Wang, Hai Zhou, Jun Peng   +9 more
doaj   +1 more source

A Phase 1 randomized trial of homologous and heterologous filovirus vaccines with a late booster dose

npj Vaccines
Filoviruses, including Ebola, Marburg, Sudan, and Taï Forest viruses, are zoonotic pathogens that can cause severe viral hemorrhagic fever and death. Developing vaccines that provide durable, broad immunity against multiple filoviruses is a high global ...
Christina A. Rostad, Inci Yildirim, Carol Kao, Jumi Yi, Satoshi Kamidani, Etza Peters, Kathleen Stephens, Theda Gibson, Hui-Mien Hsiao, Karnail Singh, Paul Spearman, Courtney McCracken, Vivien Agbakoba, Kay M. Tomashek, Johannes B. Goll, Casey E. Gelber, Robert A. Johnson, Sujin Lee, Kristal Maner-Smith, Steven Bosinger, Eric A. Ortlund, Xuemin Chen, Larry J. Anderson, Jens Wrammert, Mehul Suthar, Nadine Rouphael, Evan J. Anderson   +26 more
doaj   +1 more source

The Influence of Indisulam on Human Immune Effector Cells: Is a Combination with Immunotherapy Feasible?

Pharmaceutics
Background: As a modulator of pre-mRNA splicing, the anti-cancer agent indisulam can induce aberrantly spliced neoantigens, enabling immunologic anti-tumor activity. Consequently, combining indisulam with immunotherapy is expected to be a promising novel
Lisa Arnet, Lisabeth Emilius, Annett Hamann, Maria Carmo-Fonseca, Carola Berking, Jan Dörrie, Niels Schaft   +6 more
doaj   +1 more source

Butyrate confers colorectal cancer cell resistance to anti-PD-1 therapy by promoting CPT1A-mediated fatty acid oxidation

Discover Oncology
Immunotherapy including anti-PD-1 demonstrated therapeutic promise to colorectal cancer (CRC) patients, but tumor cell resistance limits their efficacy.
Ran Zhu, Shujiang Gu, Yuan Tao, Yan Zhang   +3 more
doaj   +1 more source