Results 31 to 40 of about 54,012 (308)

Cx43-Gap Junctions Accumulate at the Cytotoxic Immunological Synapse Enabling Cytotoxic T Lymphocyte Melanoma Cell Killing [PDF]

International Journal of Molecular Sciences, 2019
Upon tumor antigen recognition, cytotoxic T lymphocytes (CTLs) and target cells form specialized supramolecular structures, called cytotoxic immunological synapses, which are required for polarized delivery of cytotoxic granules. In previous reports, we described the accumulation of connexin 43 (Cx43)-formed gap junctions (GJs) at natural killer (NK ...
Francisca Hofmann, Mariela Navarrete, Javiera Álvarez, Israel Guerrero, María Alejandra Gleisner, Andrés Tittarelli, Flavio Salazar-Onfray   +6 more
openaire   +2 more sources

SDF-1α Reduces Human Natural Killer Cell Cytotoxicity against Chronic Myelogenous Leukemia K562 Cells

Iranian Journal of Allergy, Asthma and Immunology, 2019
Stromal cell-derived factor-1 alpha (SDF-1α) has been shown to be up-regulated in a variety of malignancies. So that, its expression is associated with poor prognosis and invasiveness.
Alireza Mardomi, Hadi Hossein-Nataj, Narjes Jafari, Nabiallah Mohammadi, Saeid Abediankenari   +4 more
doaj   +1 more source

Cytotoxicity of Reparative Endodontic Cements on Human Periodontal Ligament Stem Cells

Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 2022
Objective: To compare the cytotoxicity of commercial reparative endodontic cements on human periodontal ligament stem cells (hPDLSCs). Material and Methods: The culture of hPDLSCs was established.
Marlus da Silva Pedrosa, Tomaz Alves, Juliana Garuba Rahhal, Fernando Neves Nogueira, Carla Renata Sipert   +4 more
doaj  

Tim-3 Is Upregulated in NK Cells during Early Pregnancy and Inhibits NK Cytotoxicity toward Trophoblast in Galectin-9 Dependent Pathway. [PDF]

PLoS ONE, 2016
NK cells accumulate at the maternal-fetal interface (MFI) and play essential roles in maintaining immune tolerance during pregnancy. The mechanisms that facilitate NK cells tolerance to fetal tissue are largely unknown.
Jintang Sun, Meixiang Yang, Yanli Ban, Wenjuan Gao, Bingfeng Song, Yang Wang, Yun Zhang, Qianqian Shao, Beihua Kong, Xun Qu   +9 more
doaj   +1 more source

Cytotoxicity of polycarbonate orthodontic brackets

Brazilian Journal of Oral Sciences, 2015
Aim: To assess the cytotoxicity of polycarbonate orthodontic brackets. Methods: Polycarbonate brackets from two different manufacturers, namely, Composite bracket (Morelli™) and Silkon Plus bracket (American Orthodontics™), were assessed.
Matheus Melo Pithon, Rogério Lacerda dos Santos, Fernanda Otaviano Martins, Antônio Carlos de Oliveira Ruellas, Lincoln Issamu Nojima, Matilde Gonçalves Nojima, Maria Teresa Villela Romanos   +6 more
doaj   +1 more source

Genetic Modification of Limbal Stem Cells to Decrease Allogeneic Immune Responses

Frontiers in Immunology, 2021
Limbal stem cell (LSC) transplantation is the only efficient treatment for patients affected by LSC deficiency (LSCD). Allogeneic LSC transplantation is one of the most successful alternative for patients with bilateral LSCD.
Emilio Valdivia, Marina Bertolin, Claudia Breda, Marco Carvalho Oliveira, Anna Katharina Salz, Nicola Hofmann, Martin Börgel, Rainer Blasczyk, Stefano Ferrari, Constanca Figueiredo   +9 more
doaj   +1 more source

In Vitro Analysis of the Proliferation of HaCaT Cells Stimulated by Pigments Used for Maxillofacial Prostheses

Journal of Orofacial Sciences, 2019
Introduction: Although physical and mechanical properties are extremely important for the effectiveness of prosthetic treatment, materials used for facial rehabilitation should be biocompatible, as the maxillofacial prosthesis is in close contact with ...
Marcelo Coelho Goiato, Adhara Smith Nobrega, Estefania Marrega Malavazi, Aline Satie Takamiya, Sandra Helena Penha de Oliveira   +4 more
doaj   +1 more source

Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology [PDF]

, 2020
Combination immunotherapy (CIT) is currently applied as a treatment for different cancers and is proposed as a cure strategy for chronic viral infections. Whether such therapies are efficient during an acute infection remains elusive.
Akhmetzyanova, Ilseyar [u.v.m.], David, Paul David, Drabczyk-Pluta, Malgorzata, Gruber, Achim D., Honke, Nadine, Kershaw, Olivia, Knuschke, Torben, Megger, Dominik A., Pastille, Eva, Werner, Tanja   +9 more
core   +1 more source

Cytotoxic Isoantibodies and Immunologic Enhancement in Mice.

Experimental Biology and Medicine, 1966
Summary1. Cytotoxic isoantibodies and hemagglutinins are stimulated in response to H-2 isoantigenic differences between graft and host in mice. 2. This study offers data correlating cytotoxic isoantibody and immunological enhancement. 3. The mechanism of immunological enhancement has been shown to be associated with peripheral as well as central ...
openaire   +2 more sources

In vitro Cytotoxicity in Delayed-Type Hypersensitivity and Immunologic Tolerance.

Experimental Biology and Medicine, 1964
SummaryPicryl chloride was found to exert a lethal effect in vitro on leukocytes, principally lymphocytes, from guinea pigs exhibiting delayed-type skin reactivity to this hapten in the absence of antibody and complement. This reaction was found to be immunologically specific.
D M, LUBAROFF, R E, RITTS
openaire   +2 more sources