Results 1 to 10 of about 233,550 (154)
From CD16a Biology to Antibody-Dependent Cell-Mediated Cytotoxicity Improvement
Frontiers in Immunology, 2022 Antibody-dependent cell-mediated cytotoxicity (ADCC) is a potent cytotoxic mechanism that is mainly mediated in humans by natural killer (NK) cells. ADCC mediates the clinical benefit of several widely used cytolytic monoclonal antibodies (mAbs), and ...
Loïs Coënon +3 more
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Frontiers in Immunology, 2022 SOT101 is a superagonist fusion protein of interleukin (IL)-15 and the IL-15 receptor α (IL-15Rα) sushi+ domain, representing a promising clinical candidate for the treatment of cancer.
Zuzana Antosova +15 more
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MAbs, 2016 Although the recently concluded CLEOPATRA trial showed clinical benefits of combining trastuzumab and pertuzumab for treating HER2-positive metastatic breast cancer, trastuzumab monotherapy is still the mainstay in adjuvant settings.
György Vereb +2 more
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Enhancement of antibody-dependent cell mediated cytotoxicity: a new era in cancer treatment
ImmunoTargets and Therapy, 2015 Narendiran Rajasekaran,1,* Cariad Chester,1,* Atsushi Yonezawa,1,2 Xing Zhao,1,3 Holbrook E Kohrt1 1Division of Oncology, Stanford School of Medicine, Stanford University, Stanford, CA, USA; 2Department of Clinical Pharmacology and Therapeutics, Kyoto ...
Rajasekaran N +4 more
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Antibody-Dependent Cell Cytotoxicity in Monoclonal Antibody-Mediated Tumor Immunotherapy
OncoImmunology, 2012 Antibody-dependent cell cytotoxicity (ADCC) is critical in monoclonal antibody (mAb)-mediated cancer therapy. We recently showed that a tumor-specific mAb in combination with cyclophosphamide inhibited tumor cell growth and induced ADCC-synapses between ...
Sebastian Amigorena, Pascale Hubert
exaly +2 more sources
NK cell mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy
Frontiers in Immunology, 2015 Natural killer (NK) cells play a major role in cancer immunotherapies that involve tumor-antigen targeting by monoclonal antibodies (mAbs). NK cells express a variety of activating and inhibitory receptors that serve to regulate the function and activity
Wei eWang +5 more
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Virology, 2021 Since the COVID-19 pandemic, functional non-neutralizing antibody responses to SARS-CoV-2, including antibody-dependent cell-mediated cytotoxicity (ADCC), are poorly understood.
Xuemin Chen +9 more
semanticscholar +1 more source
Frontiers in Oncology, 2023 Therapeutic monoclonal antibodies (mAbs) are standard care for many B-cell haematological cancers. The modes of action for these mAbs include: induction of cancer cell lysis by activating Fcγ-receptors on innate immune cells; opsonising target cells for ...
Harrison D. Collier-Bain +11 more
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Siplizumab Induces NK Cell Fratricide Through Antibody-Dependent Cell-Mediated Cytotoxicity
Frontiers in Immunology, 2021 The glycoprotein CD2 is expressed on T and NK cells and contributes to cell-cell conjugation, agonistic signaling and actin cytoskeleton rearrangement. CD2 has previously been shown to have an important function in natural NK cell cytotoxicity but to be ...
Christian Binder +9 more
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Considerations of Antibody Geometric Constraints on NK Cell Antibody Dependent Cellular Cytotoxicity
Frontiers in Immunology, 2020 It has been well-established that antibody isotype, glycosylation, and epitope all play roles in the process of antibody dependent cellular cytotoxicity (ADCC).
Charles D. Murin
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