Results 1 to 10 of about 211,213 (195)

SOT101 induces NK cell cytotoxicity and potentiates antibody-dependent cell cytotoxicity and anti-tumor activity [PDF]

Frontiers in Immunology, 2022
SOT101 is a superagonist fusion protein of interleukin (IL)-15 and the IL-15 receptor α (IL-15Rα) sushi+ domain, representing a promising clinical candidate for the treatment of cancer.
Zuzana Antosova, Nada Podzimkova, Nada Podzimkova, Jakub Tomala, Katerina Augustynkova, Katerina Sajnerova, Eva Nedvedova, Milada Sirova, Guy de Martynoff, David Bechard, Ulrich Moebius, Marek Kovar, Radek Spisek, Radek Spisek, Irena Adkins, Irena Adkins   +15 more
doaj   +4 more sources

Development of antibody-dependent cell cytotoxicity function in HIV-1 antibodies [PDF]

eLife, 2021
A prerequisite for the design of an HIV vaccine that elicits protective antibodies is understanding the developmental pathways that result in desirable antibody features. The development of antibodies that mediate antibody-dependent cellular cytotoxicity
Laura E Doepker, Sonja Danon, Elias Harkins, Duncan K Ralph, Zak Yaffe, Meghan E Garrett, Amrit Dhar, Cassia Wagner, Megan M Stumpf, Dana Arenz, James A Williams, Walter Jaoko, Kishor Mandaliya, Kelly K Lee, Frederick A Matsen IV, Julie M Overbaugh   +15 more
doaj   +2 more sources

NK cell mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy

Frontiers in Immunology, 2015
Natural killer (NK) cells play a major role in cancer immunotherapies that involve tumor-antigen targeting by monoclonal antibodies (mAbs). NK cells express a variety of activating and inhibitory receptors that serve to regulate the function and activity
Wei eWang, Amy K. Erbe, Jacquelyn A. Hank, Zachary S. Morris, Paul Mark Sondel, Paul Mark Sondel   +5 more
doaj   +3 more sources

The Anti-SLAMF7 Antibody, Elotuzumab, Induces Antibody-Dependent Cellular Cytotoxicity Against CLL Cell Lines [PDF]

Molecules
SLAMF7, also known as CD319, a SLAM (signaling lymphocytic activation molecule) family receptor, is relatively weakly expressed on chronic lymphocytic leukemia (CLL) B cells.
Dominik Kľoc, Bianca Dubiková, Simona Žiláková, Ján Sykora, Michaela Šuliková, Slavomír Kurhajec, Ján Sabo, Tomáš Guman, Marek Šarišský   +8 more
doaj   +2 more sources

Feeder-Free Expanded and Cryopreserved NK Cells Retain Antibody-Dependent Cell Cytotoxicity against HER2-Positive Tumors. [PDF]

J Microbiol Biotechnol
Lee I, Kim S, Jin C, Kwack K, Baek Y.
europepmc   +3 more sources

P-1474. Development of an HIV vaccine based on 2C6, an antibody that targets a conformational gp41 epitope with cross-clade recognition and robust antibody dependent cell cytotoxicity [PDF]

Open Forum Infect Dis
Marvin Petion, Jonathan F. Lovell, Yiting Song, Shiqi Zhou, Mark D. Hicar   +4 more
europepmc   +2 more sources

Development and Validation of Cell-Based Bioassay for the Detection of Neutralizing Antibodies to Ocrelizumab in Human Serum Using Antibody-Dependent Cell-Mediated Cytotoxicity Test in a Reporter Cell Line Expressing FcγRIIIa. [PDF]

Antibodies (Basel)
Strizhakova O, Poroshin G, Pershin A, Bakhareva Y, Shevchenko I, Lyagoskin I, Shukurov R, Khamitov R.   +7 more
europepmc   +2 more sources

Evaluation of the In Vitro Capacity of Anti-Human Cytomegalovirus Antibodies to Initiate Antibody-Dependent Cell Cytotoxicity [PDF]

Microorganisms
Federica Zavaglio, Daniele Lilleri, Fausto Baldanti   +2 more
exaly   +2 more sources

Harnessing the immunomodulatory effects of exercise to enhance the efficacy of monoclonal antibody therapies against B-cell haematological cancers: a narrative review

Frontiers in Oncology, 2023
Therapeutic monoclonal antibodies (mAbs) are standard care for many B-cell haematological cancers. The modes of action for these mAbs include: induction of cancer cell lysis by activating Fcγ-receptors on innate immune cells; opsonising target cells for ...
Harrison D. Collier-Bain, Frankie F. Brown, Frankie F. Brown, Adam J. Causer, Annabelle Emery, Rebecca Oliver, Rebecca Oliver, Sally Moore, James Murray, James E. Turner, James E. Turner, John P. Campbell   +11 more
doaj   +1 more source

Siplizumab Induces NK Cell Fratricide Through Antibody-Dependent Cell-Mediated Cytotoxicity

Frontiers in Immunology, 2021
The glycoprotein CD2 is expressed on T and NK cells and contributes to cell-cell conjugation, agonistic signaling and actin cytoskeleton rearrangement. CD2 has previously been shown to have an important function in natural NK cell cytotoxicity but to be ...
Christian Binder, Christian Binder, Felix Sellberg, Felix Sellberg, Filip Cvetkovski, Stefan Berg, Erik Berglund, Erik Berglund, David Berglund, David Berglund   +9 more
doaj   +1 more source