Results 31 to 40 of about 9,958,775 (335)

Enhancing antibody-dependent cell-mediated cytotoxicity: a strategy for improving antibody-based immunotherapy

Antibody Therapeutics, 2018
The targeting of surface antigens expressed on tumor cells by monoclonal antibodies (mAbs) has revolutionized cancer therapeutics. One mechanism of action of antibody-based immunotherapy is the activation of immune effector cells to mediate antibody ...
D. Zahavi, D. Aldeghaither, Allison O'Connell, L. Weiner   +3 more
semanticscholar   +1 more source

Reimagining antibody-dependent cellular cytotoxicity in cancer: the potential of natural killer cell engagers.

Trends in immunology, 2022
Bi-, tri- and multispecific antibodies have enabled the development of targeted cancer immunotherapies redirecting immune effector cells to eliminate malignantly transformed cells.
S. Pinto, J. Pahl, A. Schottelius, P. Carter, J. Koch   +4 more
semanticscholar   +1 more source

Daratumumab-mediated lysis of primary multiple myeloma cells is enhanced in combination with the human anti-KIR antibody IPH2102 and lenalidomide

Haematologica, 2015
Despite recent treatment improvements, multiple myeloma remains an incurable disease. Since antibody-dependent cell-mediated cytotoxicity is an important effector mechanism of daratumumab, we explored the possibility of improving daratumumab-mediated ...
Inger S. Nijhof, Jeroen J. Lammerts van Bueren, Berris van Kessel, Pascale Andre, Yannis Morel, Henk M. Lokhorst, Niels W.C.J. van de Donk, Paul W.H.I. Parren, Tuna Mutis   +8 more
doaj   +1 more source

Imlifidase Inhibits HLA Antibody-Mediated NK Cell Activation and Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) In Vitro.

Transplantation, 2019
BACKGROUND Antibody-dependent cell-mediated cytotoxicity (ADCC) is an important pathway responsible for antibody-mediated rejection (AMR). Imlifidase (IdeS) cleaves human IgG into F(ab')2 and Fc fragments, potentially inhibiting ADCC.
Shi-Li Ge, M. Chu, Jua Choi, S. Louie, A. Vo, S. Jordan, M. Toyoda   +6 more
semanticscholar   +1 more source

Mechanisms of Resistance to Anti-CD38 Daratumumab in Multiple Myeloma

Cells, 2020
Daratumumab (Dara) is the first-in-class human-specific anti-CD38 mAb approved for the treatment of multiple myeloma (MM). Although recent data have demonstrated very promising results in clinical practice and trials, some patients do not achieve a ...
Ilaria Saltarella, Vanessa Desantis, Assunta Melaccio, Antonio Giovanni Solimando, Aurelia Lamanuzzi, Roberto Ria, Clelia Tiziana Storlazzi, Maria Addolorata Mariggiò, Angelo Vacca, Maria Antonia Frassanito   +9 more
doaj   +1 more source

Real time assays for quantifying cytotoxicity with single cell resolution. [PDF]

PLoS ONE, 2013
A new live cell-based assay platform has been developed for the determination of complement dependent cytotoxicity (CDC), antibody dependent cellular cytotoxicity (ADCC), and overall cytotoxicity in human whole blood.
Sonny C Hsiao, Hong Liu, Taylor A Holstlaw, Cheng Liu, Catherine Y Francis, Matthew B Francis   +5 more
doaj   +1 more source

Prospective Evaluation of Cetuximab-Mediated Antibody-Dependent Cell Cytotoxicity in Metastatic Colorectal Cancer Patients Predicts Treatment Efficacy

Cancer immunology research, 2016
It is not clear which patients with mCRC will benefit from treatment with cetuximab, an antibody to the EGF receptor. Cetuximab-mediated ADCC and NK-cell cytotoxicity ex vivo correlated with FcγR polymorphisms and could predict cetuximab responsiveness ...
A. Trotta, A. Ottaiano, C. Romano, G. Nasti, A. Nappi, C. de Divitiis, M. Napolitano, Serena Zanotta, R. Casaretti, C. D'Alterio, A. Avallone, D. Califano, R. V. Iaffaioli, S. Scala   +13 more
semanticscholar   +1 more source

Comparison of Antibody-Dependent Cell-Mediated Cytotoxicity and Virus Neutralization by HIV-1 Env-Specific Monoclonal Antibodies

Journal of Virology, 2016
Although antibodies to the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein have been studied extensively for their ability to block viral infectivity, little data are currently available on nonneutralizing functions of these antibodies,
Benjamin von Bredow, J. F. Arias, Lisa N. Heyer, B. Moldt, Khoa Le, J. Robinson, S. Zolla-Pazner, D. Burton, David T. Evans   +8 more
semanticscholar   +1 more source

The role of coronin 1 during cell mediated immune responses [PDF]

, 2013
Coronin 1 is one of 7 mammalian isoforms member of the evolutionary conserved WD40-repeat proteins that are involved in a variety of activities such a cell migration and cytokinesis.
Tchang, Vincent Sam Yong
core   +1 more source

Natural Killer (NK) Cell Education Differentially Influences HIV Antibody-Dependent NK Cell Activation and Antibody-Dependent Cellular Cytotoxicity

Frontiers in Immunology, 2017
Immunotherapy using broadly neutralizing antibodies (bNAbs) endowed with Fc-mediated effector functions has been shown to be critical for protecting or controlling viral replication in animal models.
Nicole F. Bernard, Nicole F. Bernard, Nicole F. Bernard, Nicole F. Bernard, Zahra Kiani, Zahra Kiani, Alexandra Tremblay-McLean, Alexandra Tremblay-McLean, Sanket A. Kant, Sanket A. Kant, Christopher E. Leeks, Christopher E. Leeks, Franck P. Dupuy   +12 more
doaj   +1 more source