Results 41 to 50 of about 9,958,775 (335)

Defucosylated Mouse–Dog Chimeric Anti-EGFR Antibody Exerts Antitumor Activities in Mouse Xenograft Models of Canine Tumors

Cells, 2021
The epidermal growth factor receptor (EGFR) contributes to tumor malignancy via gene amplification and protein overexpression. Previously, we developed an anti-human EGFR (hEGFR) monoclonal antibody, namely EMab-134, which detects hEGFR and dog EGFR ...
Guanjie Li, Tomokazu Ohishi, Mika K. Kaneko, Junko Takei, Takuya Mizuno, Manabu Kawada, Masaki Saito, Hiroyuki Suzuki, Yukinari Kato   +8 more
doaj   +1 more source

Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus

Proceedings of the National Academy of Sciences of the United States of America, 2016
Significance In addition to neutralizing antigens, antibodies are also capable of stimulating cellular responses through Fc–Fc receptor interactions.
Wenqian He, Ge-Ne S. Tan, Caitlin E. Mullarkey, Amanda J. Lee, M. Lam, F. Krammer, Carole Henry, P. Wilson, A. Ashkar, P. Palese, Matthew S. Miller   +10 more
semanticscholar   +1 more source

Critical role of perforin-dependent CD8+ T cell immunity for rapid protective vaccination in a murine model for human smallpox [PDF]

, 2012
Vaccination is highly effective in preventing various infectious diseases, whereas the constant threat of new emerging pathogens necessitates the development of innovative vaccination principles that also confer rapid protection in a case of emergency ...
Gerd Sutter (181175), Majzoub Monir, Sutter Gerd, Kay-Martin Hanschmann (181170), Yasemin Suezer, Kalinke Ulrich, Suezer, Yasemin, Monir Majzoub (181167), Yasemin Suezer (181158), Hanschmann Kay-Martin, Theresa Frenz, Melanie Kremer (181155), Michael H. Lehmann (181173), Lehmann Michael H., Suezer Yasemin, Michael H. Lehmann, Volz Asisa, Asisa Volz (181161), Kay-Martin Hanschmann, Michael H Lehmann, Kremer, Melanie, Asisa Volz, Ulrich Kalinke, Hanschmann, Kay-Martin, Kremer Melanie, Kalinke, Ulrich, Theresa Frenz (181164), Monir Majzoub, Sutter, Gerd, Melanie Kremer, Frenz, Theresa, Ulrich Kalinke (41173), Frenz Theresa, Gerd Sutter, Lehmann, Michael H, Volz, Asisa, Majzoub, Monir, Lehmann, Michael H.   +37 more
core   +2 more sources

IgG Fc engineering to modulate antibody effector functions

Protein & Cell, 2017
Therapeutic monoclonal antibodies are among the most effective biotherapeutics to date. An important aspect of antibodies is their ability to bind antigen while at the same time recruit immune effector functions.
Xinhua Wang, Mary Mathieu, Randall J. Brezski   +2 more
doaj   +1 more source

Enhanced killing of chordoma cells by antibody-dependent cell-mediated cytotoxicity employing the novel anti-PD-L1 antibody avelumab

OncoTarget, 2016
Chordoma, a rare bone tumor derived from the notochord, has been shown to be resistant to conventional therapies. Checkpoint inhibition has shown great promise in immune-mediated therapy of diverse cancers.
Rika Fujii, E. Friedman, J. Richards, K. Tsang, C. Heery, J. Schlom, J. Hodge   +6 more
semanticscholar   +1 more source

Integration of a virus membrane protein into the lipid bilayer of target cells as a prerequisite for immune cytolysis [PDF]

, 1979
Structural requirements for membrane antigens on target cells to mediate immune cytolysis were studied in a model system with purified membrane proteins from Semliki Forest virus (SFV). These SFV spike proteins were isolated in the form of detergent- and
Schirrmacher, V., B Morein, V Schirrmacher, Koszinowski, Ulrich H., Morein, B., D Barz, Barz, D., U Koszinowski   +7 more
core   +1 more source

Antibody - Dependent Cell - Mediated Cytotoxicity in Sheep

Acta Veterinaria Scandinavica, 1985
The ability of sheep leukocytes to mediate antibody — dependent cell-mediated cytotoxicity (ADCC) and that of sheep serum IgG1 and IgG2 to induce ADCC were investigated. Partial characterization of effector cells was attempted. These investigations revealed that ADCC occurs in sneep.
openaire   +3 more sources

Applicability of Traditional In Vitro Toxicity Tests for Assessing Adverse Effects of Monoclonal Antibodies: A Case Study of Rituximab and Trastuzumab

Antibodies, 2018
Monoclonal antibody (mAb) therapeutics have a promising outlook within the pharmaceutical industry having made positive strides in both research and development as well as commercialisation, however this development has been hampered by manufacturing ...
Arathi Kizhedath, Simon Wilkinson, Jarka Glassey   +2 more
doaj   +1 more source

Tyrosine kinase inhibitors as modulators of trastuzumab-mediated antibody-dependent cell-mediated cytotoxicity in breast cancer cell lines [PDF]

, 2017
Background\ud \ud Trastuzumab is an anti-HER2 monoclonal antibody (mAb) therapy capable of antibody-dependent cell-mediated cytotoxicity (ADCC) and used in the treatment of HER2+ breast cancer.
Hughes, Clare, Madden, Stephen F., Crown, John, Kenneth J. O'Byrne, O'Byrne, Kenneth J., Collins, Denis M., Gately, Kathy, Connla Edwards, O'Donovan, Norma, John Crown, Edwards, Connla, Clare Hughes, Norma O'Donovan, Collins, Denis, Anthony Davies, Davies, Anthony, Denis M. Collins, Kathy Gately, Stephen F. Madden   +18 more
core   +1 more source

Preclinical Characterization of a Novel Monoclonal Antibody NEO-201 for the Treatment of Human Carcinomas

Frontiers in Immunology, 2018
NEO-201 is a novel humanized IgG1 monoclonal antibody that was derived from an immunogenic preparation of tumor-associated antigens from pooled allogeneic colon tumor tissue extracts.
Massimo Fantini, Justin M. David, Olga Saric, Alexander Dubeykovskiy, Yongzhi Cui, Sharon A. Mavroukakis, Andrew Bristol, Christina M. Annunziata, Kwong Y. Tsang, Philip M. Arlen   +9 more
doaj   +1 more source