Results 61 to 70 of about 9,958,775 (335)
Scientific Reports, 2016 Analyzing the cytotoxic functions of effector cells, such as NK cells against target cancer cells, is thought to be necessary for predicting the clinical efficacy of antibody-dependent cellular cytotoxicity (ADCC) -dependent antibody therapy.
M. Yamashita +7 more
semanticscholar +1 more source
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
Cancer Research, 2007 Preliminary results from a pilot trial on trastuzumab's mechanism of action against operable breast tumors overexpressing Her2 suggested a role for antibody-dependent cell cytotoxicity (ADCC).
S. Varchetta +11 more
semanticscholar +1 more source
Natural killer cytotoxicity and antibody-dependent cytotoxicity of cells of rat metrial glands [PDF]
Reproduction, 1993 Cell suspensions of rat metrial gland tissue, containing healthy granulated metrial gland (GMG) cells, were assessed for their ability to lyse natural killer (NK) cell target Yac-1 myeloma cells in a [51Cr]-release cytotoxicity assay. Cytotoxicity indices were found to be low even after in vivo stimulation of NK cytoxic activity by polyinosilic ...
I J, Stewart, S, Peel
openaire +2 more sources
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
PLoS ONE, 2013 NaPi2b, a sodium-dependent phosphate transporter, is highly expressed in ovarian carcinomas and is recognized by the murine monoclonal antibody MX35. The antibody had shown excellent targeting to ovarian cancer in several early phase clinical trials but ...
Mariana Lopes dos Santos +12 more
doaj +1 more source
Generation of a canine anti-canine CD20 antibody for canine lymphoma treatment
Scientific Reports, 2020 Lymphoma is the most common hematological cancer in dogs. Canine diffuse large B cell lymphoma shows a relatively good response to treatment with multi-agent cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy; however, the 2 ...
Takuya Mizuno +12 more
doaj +1 more source
Different IVIG glycoforms affect in vitro inhibition of anti-ganglioside antibody-mediated complement deposition. [PDF]
PLoS ONE, 2014 Intravenous immunoglobulin (IVIG) is the first line treatment for Guillain-Barré syndrome and multifocal motor neuropathy, which are caused by anti-ganglioside antibody-mediated complement-dependent cytotoxicity.
Makoto Sudo +6 more
doaj +1 more source
Dual Fc optimization to increase the cytotoxic activity of a CD19-targeting antibody
Frontiers in Immunology, 2022 Targeting CD19 represents a promising strategy for the therapy of B-cell malignancies. Although non-engineered CD19 antibodies are poorly effective in mediating complement-dependent cytotoxicity (CDC), antibody-dependent cell-mediated cytotoxicity (ADCC)
Carina Lynn Gehlert +16 more
doaj +1 more source
mAbs, 2015 Fc effector functions such as antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cell-mediated phagocytosis (ADCP) are crucial to the efficacy of many antibody therapeutics.
M. Borrok +7 more
semanticscholar +1 more source