Results 61 to 70 of about 230,585 (263)

Development of antibody-dependent cell cytotoxicity function in HIV-1 antibodies. [PDF]

Elife, 2021
Doepker LE, Danon S, Harkins E, Ralph DK, Yaffe Z, Garrett ME, Dhar A, Wagner C, Stumpf MM, Arenz D, Williams JA, Jaoko W, Mandaliya K, Lee KK, Matsen FA, Overbaugh JM.   +15 more
europepmc   +1 more source

Antitumor activity of a novel TLR9 agonist and cooperativity with targeted agents

, 2008
Novel modified Toll-like receptor 9 (TLR9) agonists, termed immune modulatory oligonucleotides (IMOs), exhibit antitumor activity and are currently investigated in cancer patients. Intriguingly, their mechanisms of action on tumor growth and angiogenesis
Garofalo, Sonia
core  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Highly mutated monoclonal antibody 3F2 targets a conformational and strain-restricted epitope in human immunodeficiency virus gp41 with significant antibody-dependent cell cytotoxicity. [PDF]

Arch Virol, 2022
DeCotes D, Baron S, Hoffman J, Garrett M, Sojar H, Hicar MD.   +5 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Production of Transgenic Cloned Miniature Pigs with Membrane-bound Human Fas Ligand (FasL) by Somatic Cell Nuclear Transfer

, 2010
Cell-mediated xenograft rejection, including NK cells and CD8+ CTL, is a major obstacle in successful pig-to-human xenotransplantation. Human CD8+ CTL and NK cells display high cytotoxicity for pig cells, mediated at least in part by the Fas/FasL pathway.
Kwang Wook Park, Soo Hyun Kim, Jae Young Heo, Seung Pyo Hong, Ji Yeon Yoo, Yun Jin Yun, Ki Myung Choi, Young Chul Park, Jae Goo Seol, Dong-Il Jin   +9 more
core  

Studies on Antibody-Dependent Cell-Mediated Cytotoxicity of Sera from Patients with Ulcerative Colitis and Its Clinical Significance

, 1985
Several abnormalities in the immune system have been described in the pathogenesis of ulcerative colitis, although the mechanism of colonic epithelial destruction is not well elucidated yet.
Kadono, Yutaka
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Antithyroperoxidase antibody-dependent cytotoxicity in autoimmune thyroid disease.

, 2008
CONTEXT: Thyroid antibody-dependent cytotoxicity has been reported in autoimmune thyroid disease (AITD). Indeed, the role of thyroperoxidase (TPO) autoantibodies (aAbs) in complement-mediated damage by binding to TPO expressed on the surface of human ...
Castex, Françoise, Rebuffat, Sandra A, Robert, Bruno, Peraldi-Roux, Sylvie, Nguyen, Brigitte   +4 more
core   +1 more source

Eosinophil Apoptosis and Clearance in Asthma [PDF]

, 2013
Peer ...
Garry M. Walsh, Walsh, Garry M
core   +1 more source