Results 1 to 10 of about 177,282 (106)

From CD16a Biology to Antibody-Dependent Cell-Mediated Cytotoxicity Improvement [PDF]

Frontiers in Immunology, 2022
Antibody-dependent cell-mediated cytotoxicity (ADCC) is a potent cytotoxic mechanism that is mainly mediated in humans by natural killer (NK) cells. ADCC mediates the clinical benefit of several widely used cytolytic monoclonal antibodies (mAbs), and ...
Loïs Coënon, Loïs Coënon, Martin Villalba, Martin Villalba   +3 more
doaj   +2 more sources

Siplizumab Induces NK Cell Fratricide Through Antibody-Dependent Cell-Mediated Cytotoxicity [PDF]

Frontiers in Immunology, 2021
The glycoprotein CD2 is expressed on T and NK cells and contributes to cell-cell conjugation, agonistic signaling and actin cytoskeleton rearrangement. CD2 has previously been shown to have an important function in natural NK cell cytotoxicity but to be ...
Christian Binder, Christian Binder, Felix Sellberg, Felix Sellberg, Filip Cvetkovski, Stefan Berg, Erik Berglund, Erik Berglund, David Berglund, David Berglund   +9 more
doaj   +2 more sources

One N-glycan regulates natural killer cell antibody-dependent cell-mediated cytotoxicity and modulates Fc γ receptor IIIa/CD16a structure [PDF]

eLife
Both endogenous antibodies and a subset of antibody therapeutics engage Fc gamma receptor (FcγR)IIIa/CD16a to stimulate a protective immune response. Increasing the FcγRIIIa/IgG1 interaction improves the immune response and thus represents a strategy to ...
Paul G Kremer, Elizabeth A Lampros, Allison M Blocker, Adam W Barb   +3 more
doaj   +2 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity [PDF]

FEBS Open Bio
Engineering antibodies to elicit antibody‐dependent cell‐mediated cytotoxicity (ADCC) can be used to eliminate target cells. Here, we described how single domain VHH arms on a bispecific antibody (BsAb) format can be engineered to modulate cell binding ...
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
doaj   +2 more sources

NK cell mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy

Frontiers in Immunology, 2015
Natural killer (NK) cells play a major role in cancer immunotherapies that involve tumor-antigen targeting by monoclonal antibodies (mAbs). NK cells express a variety of activating and inhibitory receptors that serve to regulate the function and activity
Wei eWang, Amy K. Erbe, Jacquelyn A. Hank, Zachary S. Morris, Paul Mark Sondel, Paul Mark Sondel   +5 more
doaj   +3 more sources

TLR9 agonism differentially impacts human NK cell-mediated direct killing and antibody-dependent cell-mediated cytotoxicity [PDF]

Scientific Reports
There are two known mechanisms by which natural killer (NK) cells recognize and kill diseased targets: (i) direct killing and (ii) antibody-dependent cell-mediated cytotoxicity (ADCC).
Anna R. Mahr, Maia M. C. Bennett-Boehm, Frederik H. Rothemejer, Isabelle S. Weber, Alexander K. Regan, Josh Q. Franzen, Cami R. Bisson, Angela N. Truong, Rikke Olesen, Mariane H. Schleimann, Claudia M. Rauter, Audrey L. Smith, Dalia El-Gamal, Ole S. Søgaard, Martin Tolstrup, Paul W. Denton   +15 more
doaj   +2 more sources

Enhancement of antibody-dependent cell mediated cytotoxicity: a new era in cancer treatment [PDF]

ImmunoTargets and Therapy, 2015
Narendiran Rajasekaran,1,* Cariad Chester,1,* Atsushi Yonezawa,1,2 Xing Zhao,1,3 Holbrook E Kohrt1 1Division of Oncology, Stanford School of Medicine, Stanford University, Stanford, CA, USA; 2Department of Clinical Pharmacology and Therapeutics, Kyoto ...
Rajasekaran N, Chester C, Yonezawa A, Zhao X, Kohrt HE   +4 more
doaj   +2 more sources

Detection of Antibody-Dependent Cell-Mediated Cytotoxicity-Supporting Antibodies by NK-92-CD16A Cell Externalization of CD107a: Recognition of Antibody Afucosylation and Assay Optimization. [PDF]

Antibodies (Basel), 2023
Cruz Amaya J, Walcheck B, Smith-Gagen J, Lombardi VC, Hudig D.   +4 more
europepmc   +2 more sources

The development and kinetics of functional antibody-dependent cell-mediated cytotoxicity (ADCC) to SARS-CoV-2 spike protein. [PDF]

Virology, 2021
Chen X, Rostad CA, Anderson LJ, Sun HY, Lapp SA, Stephens K, Hussaini L, Gibson T, Rouphael N, Anderson EJ.   +9 more
europepmc   +2 more sources

Natural Killer (NK) Cell Expression of CD2 as a Predictor of Serial Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC). [PDF]

Antibodies (Basel), 2020
Tang JJ, Sung AP, Guglielmo MJ, Navarrete-Galvan L, Redelman D, Smith-Gagen J, Hudig D.   +6 more
europepmc   +2 more sources