Results 11 to 20 of about 230,585 (263)

The role of coronin 1 during cell mediated immune responses [PDF]

, 2013
Coronin 1 is one of 7 mammalian isoforms member of the evolutionary conserved WD40-repeat proteins that are involved in a variety of activities such a cell migration and cytokinesis.
Tchang, Vincent Sam Yong
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Uptake and cytotoxicity of citrate-coated gold nanospheres : comparative studies on human endothelial and epithelial cells [PDF]

, 2012
The use of gold nanoparticles (AuNPs) for diagnostic applications and for drug and gene-delivery is currently under intensive investigation. For such applications, biocompatibility and the absence of cytotoxicity of AuNPs is essential. Although generally
C Kirkpatrick, Romero, Ignacio, Kirkpatrick, C. James, Weksler Babette B, Uboldi, Chiara, Gibson, Matthew I.; id_orcid, Gibson, Matthew, Kirkpatrick, C. J. (C. James), Weksler, Babette B., Freese, Christian, Unger, Ronald E., Romero Ignacio A, Kirkpatrick, James, C., Couraud, Pierre-Olivier, Kirkpatrick C, Gibson, Matthew I., Babette B Weksler, Weksler, Babette, Kirkpatrick, James,, Pierre-Olivier Couraud, Gibson Matthew I, Kirkpatrick, C. J., Couraud Pierre-Olivier, Unger Ronald E, Chiara Uboldi, Matthew I Gibson, Ignacio A Romero, Unger, Ronald, Freese Christian, Ronald E Unger, Uboldi Chiara, Romero, Ignacio A., Christian Freese   +32 more
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A co-culture model system to quantify antibody-dependent cellular cytotoxicity in human breast cancer cells using an engineered natural killer cell line [PDF]

, 2023
Summary: Current protocols measure antibody-dependent cellular cytotoxicity (ADCC) in vitro using peripheral blood mononuclear cells (PBMCs), but isolation and variability among donors limit the viability and reproducibility of this approach.
Roos Vincken, Ana Ruiz-Saenz, Vincken, Roos, Ruiz-Saenz, Ana   +3 more
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From CD16a Biology to Antibody-Dependent Cell-Mediated Cytotoxicity Improvement

, 2022
Antibody-dependent cell-mediated cytotoxicity (ADCC) is a potent cytotoxic mechanism that is mainly mediated in humans by natural killer (NK) cells. ADCC mediates the clinical benefit of several widely used cytolytic monoclonal antibodies (mAbs), and ...
Villalba, Martin, Coënon, Loïs
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Critical role of perforin-dependent CD8+ T cell immunity for rapid protective vaccination in a murine model for human smallpox [PDF]

, 2012
Vaccination is highly effective in preventing various infectious diseases, whereas the constant threat of new emerging pathogens necessitates the development of innovative vaccination principles that also confer rapid protection in a case of emergency ...
Gerd Sutter (181175), Majzoub Monir, Sutter Gerd, Kay-Martin Hanschmann (181170), Yasemin Suezer, Kalinke Ulrich, Suezer, Yasemin, Monir Majzoub (181167), Yasemin Suezer (181158), Hanschmann Kay-Martin, Theresa Frenz, Melanie Kremer (181155), Michael H. Lehmann (181173), Lehmann Michael H., Suezer Yasemin, Michael H. Lehmann, Volz Asisa, Asisa Volz (181161), Kay-Martin Hanschmann, Michael H Lehmann, Kremer, Melanie, Asisa Volz, Ulrich Kalinke, Hanschmann, Kay-Martin, Kremer Melanie, Kalinke, Ulrich, Theresa Frenz (181164), Monir Majzoub, Sutter, Gerd, Melanie Kremer, Frenz, Theresa, Ulrich Kalinke (41173), Frenz Theresa, Gerd Sutter, Lehmann, Michael H, Volz, Asisa, Majzoub, Monir, Lehmann, Michael H.   +37 more
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Tyrosine kinase inhibitors as modulators of trastuzumab-mediated antibody-dependent cell-mediated cytotoxicity in breast cancer cell lines [PDF]

, 2017
Background\ud \ud Trastuzumab is an anti-HER2 monoclonal antibody (mAb) therapy capable of antibody-dependent cell-mediated cytotoxicity (ADCC) and used in the treatment of HER2+ breast cancer.
Hughes, Clare, Madden, Stephen F., Crown, John, Kenneth J. O'Byrne, O'Byrne, Kenneth J., Collins, Denis M., Gately, Kathy, Connla Edwards, O'Donovan, Norma, John Crown, Edwards, Connla, Clare Hughes, Norma O'Donovan, Collins, Denis, Anthony Davies, Davies, Anthony, Denis M. Collins, Kathy Gately, Stephen F. Madden   +18 more
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Siplizumab Induces NK Cell Fratricide Through Antibody-Dependent Cell-Mediated Cytotoxicity

, 2021
The glycoprotein CD2 is expressed on T and NK cells and contributes to cell-cell conjugation, agonistic signaling and actin cytoskeleton rearrangement. CD2 has previously been shown to have an important function in natural NK cell cytotoxicity but to be ...
Cvetkovski, Filip,, Berg, Stefan,, Berglund, Erik, Sellberg, Felix, Sellberg, Felix,, Cvetkovski, Filip, Berg, Stefan, Berglund, David,, Binder, Christian, Berglund, David, Berglund, Erik,, Binder, Christian,   +11 more
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Transforming Growth Factor Alpha Stimulation of Mucosal Tissue Cultures from Head and Neck Squamous Cell Carcinoma Patients Increases Chemoresistance to Cisplatin [PDF]

, 2010
The monoclonal epidermal growth factor receptor ( EGFR) antibody cetuximab (Erbitux(TM)) was recently approved by the European Medicines Agency for the treatment of recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) in combination ...
Baumeister, Philipp, Ulrich Harréus, Schwenk-Zieger, Sabina, Maximilian Reiter, Philipp Baumeister, Reiter, Maximilian, Sabina Schwenk-Zieger, Harreus, Ulrich   +7 more
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Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Development of antibody technology to identify natural killer cell surface antigens in Xenopus Laevis [PDF]

, 1999
Natural killer (NK)-like lymphocytes have recently been identified in thymectomised (Tx) Xenopus which are capable of spontaneous cytotoxicity towards the MHC- deficient, allogeneic thymus tumour cell line B(_3)B(_7).
Minter, Ralph
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