Results 1 to 10 of about 46,338 (117)

Cholestasis: exploring the triangular relationship of gut microbiota-bile acid-cholestasis and the potential probiotic strategies

Gut Microbes, 2023
Cholestasis is a condition characterized by the abnormal production or excretion of bile, and it can be induced by a variety of causes, the factors of which are extremely complex.
Jianxin Zhao, Fengwei Tian, Arjan Narbad   +2 more
exaly   +3 more sources

Cholestasis: human disease and experimental animal models

Annals of Hepatology, 2003
Cholestasis may result from a failure in bile secretion in hepatocytes or ductular cells, or from a blockade to the free bile flow. Human cholestasis may be induced by many drugs, being antibiotics the more common.
Emilio Alberto Rodríguez-Garay, MD, PhD
exaly   +3 more sources

EVALUATION OF RISK FACTORS FOR INTRAHEPATIC CHOLESTASIS OF PREGNANCY IN PATIENTS PRESENTING TO A TERTIARY CARE CENTRE

Pakistan Armed Forces Medical Journal, 2021
Objectives: To evaluate the principal risk factors associated with development of intrahepatic cholestasis of pregnancy (ICP) in patients presenting to a tertiary care hospital. Study Design: Case control study.
Rabiah Anwar, Kashif Razzaq, Aysha Shahid, Afeera Afsheen, Amera Tariq, Irum Saleem   +5 more
doaj   +3 more sources

Outcomes of 38 patients with PFIC3: Impact of genotype and of response to ursodeoxycholic acid therapy

JHEP Reports, 2023
Background & Aims: Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a rare liver disease caused by biallelic variations in ABCB4. Data reporting on the impact of genotype and of response to ursodeoxycholic acid (UDCA) therapy on long ...
Emmanuel Gonzales, Antoine Gardin, Marion Almes, Amaria Darmellah-Remil, Hanh Seguin, Charlotte Mussini, Stéphanie Franchi-Abella, Mathieu Duché, Oanez Ackermann, Alice Thébaut, Dalila Habes, Bogdan Hermeziu, Martine Lapalus, Thomas Falguières, Jean-Philippe Combal, Bernard Benichou, Sonia Valero, Anne Davit-Spraul, Emmanuel Jacquemin   +18 more
doaj   +1 more source

Effect of transient obstructive cholestasis on liver histology: a cross-sectional study

São Paulo Medical Journal, 2021
BACKGROUND: The role of transient obstructive cholestasis on liver histology remains undetermined. OBJECTIVE: To investigate whether transient cholestasis impairs liver histology.
Thalita Mendes Mitsunaga, Laísa Simakawa Jimenez, Pedro França da Costa Soares, Martinho Antonio Gestic, Murillo Pimentel Utrini, Felipe David Mendonça Chaim, Francisco Callejas-Neto, Elinton Adami Chaim, Everton Cazzo   +8 more
doaj   +1 more source

CHRONIC CHOLESTASIS IN INFANCY [PDF]

Romanian Journal of Pediatrics, 2009
This article focuses on the few disorders that produce chronic cholestasis in infants. The author presents: definition and pathophysiology of cholestasis; the consequences of cholestasis; an approach to diagnosis of cholestasis in infancy and childhood;
Daniela Patrichi
doaj   +1 more source

Neonatal cholestasis as the onset symptom of McCune–Albright syndrome: case reports and a literature review

Frontiers in Pediatrics, 2023
AimThis study aimed to summarize and show the characteristics and evolutionary process of neonatal cholestasis caused by McCune–Albright syndrome (MAS), as neonatal cholestasis may be the initial manifestation of MAS before other classic clinical ...
Weiyuan Fang, Yanhui Zhang, Lian Chen, Xinbao Xie   +3 more
doaj   +1 more source

A meta-analysis of the prevalence of gestational diabetes in patients diagnosed with obstetrical cholestasisAJOG Global Reports at a Glance

AJOG Global Reports, 2021
BACKGROUND: Gestational diabetes and obstetrical cholestasis are common clinical conditions seen in clinical practice. There is evidence suggesting a coexisting relationship that could have a potential clinical implication related to stillbirth outcomes.
Manoj Mohan, MRCOG, Sanjay Swargathmadhom Prabhu, MRCOG, Abdul Kareem Pullattayil, MSIt, Stephen Lindow, FRCOG   +3 more
doaj   +1 more source

Hypercortisolism in patients with cholestasis is associated with disease severity

BMC Gastroenterology, 2021
Background Cholestasis might lead to an impairment of adrenal function as suggested by in vitro and in vivo data as well as by clinical findings. Bile acid and adrenal steroid metabolism not only share the receptors farnesoid X receptor (FXR) and the G ...
Verena Theiler-Schwetz, Hansjörg Schlager, Barbara Obermayer-Pietsch, Tatjana Stojakovic, Günter Fauler, Peter Fickert, Gernot Zollner   +6 more
doaj   +1 more source

Distribution of endotoxin in maternal and fetal body with intrahepatic cholestasis of pregnancy and its association with adverse fetal outcome

BMC Pregnancy and Childbirth, 2022
Background Intrahepatic cholestasis of pregnancy is a pregnancy-specific liver disease. In this study, we sought to explore the distribution of lipopolysaccharide in the maternal body, and its effect on the fetal body in the intrahepatic cholestasis of ...
Xiaomei Huang, Lei Lei, Fan Feng, Yong Shao   +3 more
doaj   +1 more source