Results 1 to 10 of about 27,297 (261)

Antimicrobial and healing efficacy of bile salts with insights into cytotoxic activity [PDF]

Scientific Reports
Bile salts play crucial roles in lipid digestion and metabolism, with emerging evidence suggesting their involvement in cell signaling, wound healing, and potential antimicrobial activities.
Aisha M. H. Al-Rajhi, Sulaiman A. Alsalamah, Abdullah M. Almotayri, Nourah M. Almimoni, Rabab A. Hegazy, Husam Qanash, Tarek M. Abdelghany   +6 more
doaj   +2 more sources

Comprehensive evaluation of the bactericidal activities of free bile acids in the large intestine of humans and rodents

Journal of Lipid Research, 2017
In addition to functioning as detergents that aid digestion of dietary lipids in the intestine, some bile acids have been shown to exhibit antimicrobial activity.
Masamichi Watanabe, Satoru Fukiya, Atsushi Yokota   +2 more
doaj   +3 more sources

Identification of bile acid-CoA:amino acid N-acyltransferase as the hepatic N-acyl taurine synthase for polyunsaturated fatty acids

Journal of Lipid Research, 2023
N-acyl taurines (NATs) are bioactive lipids with emerging roles in glucose homeostasis and lipid metabolism. The acyl chains of hepatic and biliary NATs are enriched in polyunsaturated fatty acids (PUFAs).
Samuel A.J. Trammell, Luke F. Gamon, Kamil Gotfryd, Katja Thorøe Michler, Bandar D. Alrehaili, Iben Rix, Filip K. Knop, Pontus Gourdon, Yoon-Kwang Lee, Michael J. Davies, Matthew P. Gillum, Trisha J. Grevengoed   +11 more
doaj   +1 more source

Effect of Digestion on Ursolic Acid Self-Stabilized Water-in-Oil Emulsion: Role of Bile Salts

Foods, 2023
Exploring the effect of bile salts on the properties of emulsion carriers containing hydrophobic bioactive compounds is particularly critical to understanding the stability and bioavailability of these hydrophobic bioactive compounds in the digestive ...
Yumeng Yan, Yugang Liu, Chaoxi Zeng, Huiping Xia   +3 more
doaj   +1 more source

A new insight into the physiological role of bile salt hydrolase among intestinal bacteria from the genus Bifidobacterium. [PDF]

PLoS ONE, 2014
This study analyzes the occurrence of bile salt hydrolase in fourteen strains belonging to the genus Bifidobacterium. Deconjugation activity was detected using a plate test, two-step enzymatic reaction and activity staining on a native polyacrylamide gel.
Piotr Jarocki, Marcin Podleśny, Paweł Glibowski, Zdzisław Targoński   +3 more
doaj   +1 more source

Role of Bile Acids and Bile Salts in Acute Pancreatitis

Pancreas, 2021
Abstract Acute pancreatitis (AP) is one of the most common gastroenterological disorders leading to hospitalization. It has long been debated whether biliary AP, about 30% to 50% of all cases, is induced by bile acids (BAs) when they reach the pancreas via reflux or via the systemic blood circulation.
Tran, Quang Trung, Tran, Van Huy, Sendler, Matthias, Doller, Julia, Wiese, Mats, Bolsmann, Robert, Wilden, Anika, Glaubitz, Juliane, Modenbach, Jana Marielle, Thiel, Franziska Gisela, de Freitas Chama, Laura L., Weiss, Frank Ulrich, Lerch, Markus M., Aghdassi, Ali A.   +13 more
openaire   +3 more sources

The economy of the enterohepatic circulation of bile acids in the baboon. 2. Regulation of bile acid synthesis by enterohepatic circulation of bile acids.

Journal of Lipid Research, 1984
Isotope dilution within bile acid pools and radiochemical assessment of cholesterol oxidation to bile acids were methods used to measure short-term feedback regulation of bile acid synthesis in baboons with controlled enterohepatic circulations ...
R N Redinger
doaj   +1 more source

Bile acid solubility and precipitation in vitro and in vivo: the role of conjugation, pH, and Ca2+ ions.

Journal of Lipid Research, 1992
The principles governing the in vitro solubility of the common natural conjugated and unconjugated bile acids and salts in relation to pH, micelle formation, and Ca2+ concentration are considered from a theoretical standpoint and then correlated first ...
AF Hofmann, KJ Mysels
doaj   +1 more source

Brucella abortus choloylglycine hydrolase affects cell envelope composition and host cell internalization. [PDF]

PLoS ONE, 2011
Choloylglycine hydrolase (CGH, E.C. 3.5.1.24) is a conjugated bile salt hydrolase that catalyses the hydrolysis of the amide bond in conjugated bile acids.
María Inés Marchesini, Joseph Connolly, María Victoria Delpino, Pablo C Baldi, Cesar V Mujer, Vito G DelVecchio, Diego J Comerci   +6 more
doaj   +1 more source

Bile salts of vertebrates: structural variation and possible evolutionary significance[S]

Journal of Lipid Research, 2010
Biliary bile salt composition of 677 vertebrate species (103 fish, 130 reptiles, 271 birds, 173 mammals) was determined. Bile salts were of three types: C27 bile alcohols, C27 bile acids, or C24 bile acids, with default hydroxylation at C-3 and C-7.
Alan F. Hofmann, Lee R. Hagey, Matthew D. Krasowski   +2 more
doaj   +1 more source