Results 1 to 10 of about 7,131 (121)

Taurocholic Acid and Glycocholic Acid Inhibit Inflammation and Activate Farnesoid X Receptor Expression in LPS-Stimulated Zebrafish and Macrophages [PDF]

Molecules, 2023
A hyperactive immune response can be observed in patients with bacterial or viral infection, which may lead to the overproduction of proinflammatory cytokines, or “cytokine storm”, and a poor clinical outcome. Extensive research efforts have been devoted
Xutao Ge, Shaoze Huang, Can Ren, Lu Zhao
doaj   +4 more sources

RETRACTED: Mancinelli et al. The Effects of Taurocholic Acid on Biliary Damage and Liver Fibrosis Are Mediated by Calcitonin-Gene-Related Peptide Signaling. Cells 2022, 11, 1591 [PDF]

Cells
The journal retracts the article titled “The Effects of Taurocholic Acid on Biliary Damage and Liver Fibrosis Are Mediated by Calcitonin-Gene-Related Peptide Signaling” [...]
Romina Mancinelli, Ludovica Ceci, Lindsey Kennedy, Heather Francis, Vik Meadows, Lixian Chen, Guido Carpino, Konstantina Kyritsi, Nan Wu, Tianhao Zhou, Keisaku Sato, Luigi Pannarale, Shannon Glaser, Sanjukta Chakraborty, Gianfranco Alpini, Eugenio Gaudio, Paolo Onori, Antonio Franchitto   +17 more
doaj   +2 more sources

Taurocholic acid promotes hepatic stellate cell activation via S1PR2/p38 MAPK/YAP signaling under cholestatic conditions [PDF]

Clinical and Molecular Hepatology, 2023
Background/Aims Disrupted bile acid regulation and accumulation in the liver can contribute to progressive liver damage and fibrosis. However, the effects of bile acids on the activation of hepatic stellate cells (HSCs) remain unclear.
Jing Yang, Xujiao Tang, Zhu Liang, Mingzhu Chen, Lixin Sun   +4 more
doaj   +2 more sources

Chronic liver diseases aggravate radiation-induced intestinal injury through taurocholic acid dysregulation [PDF]

Journal of Translational Medicine
Background Chronic liver diseases (CLDs) are pervasive health issue worldwide, whereas radiation-induced intestinal injury is a frequent and consequential complication of abdominopelvic radiotherapy.
Bin Wang, Qi Wang, Yanxi Dong, Yuan Li, Jia Liu, Yunong Xiao, Jiwei Qiu, Jiali Dong, Huiwen Xiao, Ming Cui   +9 more
doaj   +2 more sources

Taurocholic acid induces intrahepatic cholangiocyte cell proliferation via activating NRAS and YAP1 [PDF]

PLoS ONE
Biliary atresia is a neonatal cholangiopathy characterized by loss of the extrahepatic bile duct causing bile acid accumulation in the liver and subsequent fibro inflammation and abnormal proliferation of intrahepatic ducts.
Lum Fube, Arul Thason, Elizabeth Taliaferro, Carol Heckman, Surya Amarachintha   +4 more
doaj   +3 more sources

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression [PDF]

Advanced Science
Major Depressive Disorder (MDD) is characterized by abnormal metabolic profiles along the microbiome‐gut‐brain axis. Bile acids (BAs), a class of steroid compounds regulated by the host and microbes, are increasingly shown to become dysregulated in ...
Xiaoying Cai, Taipeng Sun, Mengzhen Feng, Gang Chen, Junchi Zhou, Hong Zhuang, Dan Wang, Ying Chen, Zhen Cheng, Zhi Xu, Xiao Zheng, Xueli Zhang, Yonggui Yuan   +12 more
doaj   +2 more sources

Baat-Deficient Mice Recapitulate Elevated 7α-Hydroxy-3-Oxo-4-Cholestenoic Acid Observed in a Japanese Patient With BAAT Deficiency. [PDF]

J Inherit Metab Dis
ABSTRACTBile acid Coenzyme A: amino acid N‐acyltransferase (BAAT) catalyzes the conjugation of bile acids with taurine or glycine, a process essential for bile acid solubility and intestinal lipid absorption. Mutations in BAAT cause an inborn error of bile acid metabolism, typically characterized by reduced conjugated bile acids and fat‐soluble vitamin
Koga S, Takei H, Tamura R, Takaki Y, Kusuhara H, Nittono H, Hayashi H.   +6 more
europepmc   +2 more sources

Validation of NBD-coupled taurocholic acid for intravital analysis of bile acid transport in liver and kidney of mice [PDF]

EXCLI Journal : Experimental and Clinical Sciences
Fluorophore-coupled bile acids (BA) represent an important tool for intravital analysis of BA flux in animal models of cholestatic diseases. However, addition of a fluorophore to a BA may alter transport properties. We developed and validated a 4-chloro-
Ahmed Ghallab, Sebastian Kunz, Celine Drossel, Veronica Billo, Adrian Friebel, Mats Georg, Richard Göttlich, Zaynab Hobloss, Reham Hassan, Maiju Myllys, Abdel-latief Seddek, Noha Abdelmageed, Paul A. Dawson, Erik Lindström, Stefan Hoehme, Jan G. Hengstler, Joachim Geyer   +16 more
doaj   +2 more sources

Anti-inflammatory effects of taurocholic acid and tauroursodeoxycholic acid from rainbow trout spleen extract via NF-κB suppression [PDF]

Scientific Reports
Inflammation is an essential innate immune response, yet excessive or persistent inflammation contributes to chronic inflammatory diseases. Our previous studies demonstrated that rainbow trout spleen extracts possess potent anti-inflammatory activity ...
Do-Yeon Kim, Woo-Sung Choi, Ju-Hee Park, Seoghyun Kim, Jinyoung Park, Woohyun Song, Heejung Yang, Jaeseok Choi, Han-Heom Na, Sungjin Moon, Keun-Cheol Kim   +10 more
doaj   +2 more sources

FDX1-mediated cuproptosis promotes cholestatic liver injury exacerbated by taurocholic acid-enhanced copper accumulation [PDF]

Cell Death Discovery
Cholestatic liver injury, characterized by direct exposure of hepatocytes to retained bile components with elevated concentrations, represents a common manifestation of various hepatobiliary disorders with persistent threats to long-term patient survival
Yujun Guo, Min Yang, Shengbo Sun, Zhaohua Zhong, Wenjun Lu, Ze’nan Zhang, Meili Fan, Aodan Zhang, Tingting Zhang, Yang Wu, Zhou Li, Zuwei Liu, Qijun Sun, Zhaozhu Li, Qingbo Cui   +14 more
doaj   +2 more sources