Results 31 to 40 of about 6,842 (160)

Hepatitis D Virus Entry Inhibitors Based on Repurposing Intestinal Bile Acid Reabsorption Inhibitors

Viruses, 2021
Identification of Na+/taurocholate co-transporting polypeptide (NTCP) as high-affinity hepatic entry receptor for the Hepatitis B and D viruses (HBV/HDV) opened the field for target-based development of cell-entry inhibitors. However, most of the HBV/HDV
Michael Kirstgen, Kira Alessandra Alicia Theresa Lowjaga, Simon Franz Müller, Nora Goldmann, Felix Lehmann, Dieter Glebe, Karl-Heinz Baringhaus, Joachim Geyer   +7 more
doaj   +1 more source

Uptake of Taurocholic Acid into Isolated Rat‐Liver Cells [PDF]

European Journal of Biochemistry, 1975
Binding and transport characteristics for uptake of taurocholic acid by isolated rat liver cells were studied. An adsorption of taurocholate to the cell surface is terminated in less than 15 s. A Ks of 0.55 mM and a total binding capacity of 3.8 nmol/mg cell protein is determined.
L R, Schwarz, R, Burr, M, Schwenk, E, Pfaff, H, Greim   +4 more
openaire   +2 more sources

The value of grip test, lysophosphatidlycholines, glycerophosphocholine, ornithine, glucuronic acid decrement in assessment of nutritional and metabolic characteristics in hepatitis B cirrhosis. [PDF]

PLoS ONE, 2017
The liver is essential for the regulation of energy, protein and amino acids, as well as in other aspects of metabolism. To identify efficient indexes for evaluation of nutritional status and metabolic characteristics during different Child-Pugh stages ...
Qing Ye, Weili Yin, Lei Zhang, Huijuan Xiao, Yumei Qi, Shuye Liu, Baoxin Qian, Fengmei Wang, Tao Han   +8 more
doaj   +1 more source

Taurine Grafted Micro-Implants Improved Functions without Direct Dependency between Interleukin-6 and the Bile Acid Lithocholic Acid in Plasma

Biomedicines, 2022
A recent study showed an association between diabetes development and the bile acid lithocholic acid (LCA), while another study demonstrated positive biological effects of the conjugated bile acid, taurocholic acid (TCA), on pancreatic cells.
Armin Mooranian, Corina Mihaela Ionescu, Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Melissa Jones, Jacqueline Chester, Thomas Foster, Edan Johnston, Sanja Kojic, Goran Stojanovic, Momir Mikov, Hani Al-Salami   +12 more
doaj   +1 more source

Inhibition of ileal sodium-dependent bile acid transport by 2164U90.

Journal of Lipid Research, 1995
Inhibition of the ileal bile acid active transport system, previously shown to be mechanism underlying the hypocholesterolemic activity of 2164U90 in rodents, was further characterized in isolated intestinal preparations from three species.
C Root, C D Smith, D A Winegar, L E Brieaddy, M C Lewis   +4 more
doaj   +1 more source

Taurocholic acid improves hepatocyte lipid deposition by regulating macrophage polarization through TGR5

陆军军医大学学报, 2023
Objective To investigate the effect of taurocholic acid (TLCA) regulating palmitic acid (PA)-induced macrophage polarization on hepatocyte lipid metabolism.
MA Qin, MA Qin, JIANG Lincheng, JIANG Lincheng   +3 more
doaj   +1 more source

Deletion of mouse FXR gene disturbs multiple neurotransmitter systems and alters neurobehavior

Frontiers in Behavioral Neuroscience, 2015
Farnesoid X receptor (FXR) is a nuclear hormone receptor involved in bile acid synthesis and homeostasis. Dysfunction of FXR is involved in cholestasis and atherosclerosis.
Fei eHuang, Tingting eWang, Yunyi eLan, Li eYang, Weihong ePan, Yonghui eZhu, Boyang eLv, Yuting eWei, Hailian eShi, Hui eWu, Beibei eZhang, Jie eWang, Xiaofeng eDuan, Zhibi eHu, Xiaojun eWu   +14 more
doaj   +1 more source

Serum Taurocholic Acid Levels Have Predictive Value for Adverse Maternal and Infant Outcomes in Pregnant Women with Intrahepatic Cholestasis of Pregnancy: A Prospective Cohort Study

Clinical and Experimental Obstetrics & Gynecology, 2023
Background: Intrahepatic cholestasis of pregnancy (ICP) is a common liver disorder specific to pregnancy. Taurocholic acid (TCA) has been implicated in the pathogenesis of ICP.
Yan Chen, Hong Li, Huanhuan Guo, Junjie Zhou   +3 more
doaj   +1 more source

A gut–brain axis regulating glucose metabolism mediated by bile acids and competitive fibroblast growth factor actions at the hypothalamus

Molecular Metabolism, 2018
Objective: Bile acids have been implicated as important regulators of glucose metabolism via activation of FXR and GPBAR1. We have previously shown that FGF19 can modulate glucose handling by suppressing the activity of hypothalamic AGRP/NPY neurons.
Shunmei Liu, Genevieve Marcelin, Clemence Blouet, Jae Hoon Jeong, Young-Hwan Jo, Gary J. Schwartz, Streamson Chua, Jr.   +6 more
doaj   +1 more source

Effects of 2164U90 on ileal bile acid absorption and serum cholesterol in rats and mice.

Journal of Lipid Research, 1995
2164U90, [(3R,5R)-trans-3-butyl-3-ethyl-2,3,4,5-tetrahydro-5-phenyl-1,4- benzothiazepine 1,1-dioxide], was found to be a potent inhibitor of the ileal bile acid active transport system.
M C Lewis, L E Brieaddy, C Root
doaj   +1 more source