Results 31 to 40 of about 6,894 (164)

Effects of Dietary Nutrients on Intestinal Taurocholic Acid Absorption

Experimental Biology and Medicine, 1981
AbstractIn order to assess the intraluminal event that may be responsible for bile acid malabsorption in cystic fibrosis, taurocholic acid absorption was determined in the presence and absence of representative unhydrolyzed dietary nutrients in animal models.
J D, Fondacaro, R H, Wolcott
openaire   +2 more sources

The composition of bile acids in patients with cholelithiasis according to the data of liquid chromatography with mass spectrometric detection

Zaporožskij Medicinskij Žurnal, 2017
Bile acids play a leading role in the physical and colloidal properties of bile stabilization. Lack of bile acids consequences result in the formation of cholesterol stones in the gall bladder, diarrhea and steatorrhea, fat-soluble vitamins impaired ...
V. M. Klymenko, D. V. Syvolap, A. G. Kaplaushenko, B. O. Varynskyi   +3 more
doaj   +1 more source

Combination of Plasma-Based Metabolomics and Machine Learning Algorithm Provides a Novel Diagnostic Strategy for Malignant Mesothelioma

Diagnostics, 2021
Background: Malignant mesothelioma (MM) is an aggressive and incurable carcinoma that is primarily caused by asbestos exposure. However, the current diagnostic tool for MM is still under-developed.
Na Li, Chenxi Yang, Sicheng Zhou, Siyu Song, Yuyao Jin, Ding Wang, Junping Liu, Yun Gao, Haining Yang, Weimin Mao, Zhongjian Chen   +10 more
doaj   +1 more source

Adaptation of the gut pathobiont Enterococcus faecalis to deoxycholate and taurocholate bile acids

Scientific Reports, 2022
AbstractEnterococcus faecalis is a natural inhabitant of the human gastrointestinal tract. This bacterial species is subdominant in a healthy physiological state of the gut microbiota (eubiosis) in adults, but can become dominant and cause infections when the intestinal homeostasis is disrupted (dysbiosis).
Repoila, Francis, Le Bohec, F., Guérin, C., Lacoux, C., Tiwari, S., Jaiswal, A., Santana, M. Passos, Kennedy, Sean P., Quinquis, B., Rainteau, D., Juillard, V., Furlan, S., Bouloc, P., Nicolas, P., Miyoshi, A., Azevedo, V., Serror, Pascale   +16 more
openaire   +5 more sources

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Evaluation of the 3 alpha-hydroxysteroid dehydrogenase assay for ursodeoxycholic acid, and 7 oxo- and 12 oxo- bile acids

Journal of Lipid Research, 1980
3 alpha-Hydroxysteroid dehydrogenase (SDH) quantifies ursodeoxycholic acid, 3 alpha,12 alpha-diol-7-one-5 beta-cholanoic acid, 3 alpha-ol-7-one-5 beta-cholanoic acid, and 3 alpha,7 alpha-diol-12-one-5 beta-cholanoic acid in a manner similar to the more ...
L J Haeffner, S J Gordon, J S Magen, O D Kowlessar   +3 more
doaj   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Integrated assessment of rifampicin‐mediated induction of transporters and drug‐metabolizing enzymes in a long‐term human liver tissue chip system

Clinical Pharmacology &Therapeutics, EarlyView.
Rifampicin is a prototypical clinical inducer used in drug–drug interaction (DDI) studies. However, the clinical relevance and predictability of rifampicin‐mediated hepatic transporter induction remain poorly defined. Conventional hepatocyte culture models fail to capture clinically relevant regulation of transporters and drug‐metabolizing enzymes ...
Mattie E. Hartauer, Raeanne M. Lanphier, Shivam Ohri, Jessica Snyder, Jacqueline B. Tiley, John K. Fallon, Henry Ho, Murat Cirit, Shiny Amala Priya Rajan, Kim L. R. Brouwer   +9 more
wiley   +1 more source

Plasma metabolomics signatures of developmental dysplasia of the hip in Tibet plateau

Orphanet Journal of Rare Diseases
Background Developmental dysplasia of the hip (DDH) is a common childhood health complaint, whose etiology is multifactorial. The incidence of DDH is variable and higher in Tibet plateau.
Ye Guo, Xiaogang Li, De Yang, Nyima Yedron, Tao Chen, Jianchu Li, Yanming Lei, Ping Li, Jiamei Ji, Li Shi, Xiao Yang, Ten Cho   +11 more
doaj   +1 more source

MALDI imaging MS reveals candidate lipid markers of polycystic kidney disease[S]

Journal of Lipid Research, 2013
Autosomal recessive polycystic kidney disease (ARPKD) is a severe, monogenetically inherited kidney and liver disease. PCK rats carrying the orthologous mutant gene serve as a model of human disease, and alterations in lipid profiles in PCK rats suggest ...
Hermelindis Ruh, Theresia Salonikios, Jens Fuchser, Matthias Schwartz, Carsten Sticht, Christina Hochheim, Bernhard Wirnitzer, Norbert Gretz, Carsten Hopf   +8 more
doaj   +1 more source