Results 31 to 40 of about 2,522,698 (156)

Taurocholic acid improves hepatocyte lipid deposition by regulating macrophage polarization through TGR5

陆军军医大学学报, 2023
Objective To investigate the effect of taurocholic acid (TLCA) regulating palmitic acid (PA)-induced macrophage polarization on hepatocyte lipid metabolism.
MA Qin, MA Qin, JIANG Lincheng, JIANG Lincheng   +3 more
doaj   +1 more source

The composition of bile acids in patients with cholelithiasis according to the data of liquid chromatography with mass spectrometric detection

Zaporožskij Medicinskij Žurnal, 2017
Bile acids play a leading role in the physical and colloidal properties of bile stabilization. Lack of bile acids consequences result in the formation of cholesterol stones in the gall bladder, diarrhea and steatorrhea, fat-soluble vitamins impaired ...
V. M. Klymenko, D. V. Syvolap, A. G. Kaplaushenko, B. O. Varynskyi   +3 more
doaj   +1 more source

Biliary microbiota and bile acid composition in cholelithiasis [PDF]

, 2020
Background. A functional interplay between BAs and microbial composition in gut is a well-documented phenomenon. In bile, this phenomenon is far less studied, and with this report, we describe the interactions between the BAs and microbiota in this ...
Petrov, Viacheslav, Derks, R., Sazonov, A.E., Merzlikin, N.V., Saltykova, I. V., Merzlikin, N. V., Saltykova, I.V., Sazonov, A. E., Mayboroda, O. A., Petrov, V.A., Knyazeva, E. M., Fernandez-Peralbo, M.A., Knyazeva, E.M., Mayboroda, O.A., Fernández-Peralbo, M. A.   +14 more
core   +1 more source

Taurocholic acid, a primary 12 alpha-hydroxylated bile acid, induces leakiness in the distal small intestine in rats

, 2022
A high-fat diet increases 12 alpha-hydroxylated (12 alpha OH) bile acid (BA) secretion in rats, and secondary BAs are responsible for the leaky gut. This study aimed to examine the role of primary 12 alpha OH BAs in gut barrier impairment in rats using ...
Kohmoto, Ohji, Tochigi, Misuzu, Ishizuka, Satoshi, Tada, Koji, Liu, Hongxia, Sakaguchi, Ayana, Hori, Shota, Lee, Yeonmi, Kikuchi, Keidai   +8 more
core   +1 more source

Stimulation of taurocholic acid synthesis and biliary excretion of lipids

, 1961
The rates of excretion of taurocholic acid and lipids in the bile of the isolated perfused liver and the bile fistula rat were determined. In the bile fistula rats, there was, during the first 12 hours after cannulation, a fall in the excretion of ...
Cecil Entenman, Robert E. Kay
core   +1 more source

Inhibition potencies of steroid, steroid conjugates, bile acids and drugs for SLC22A24-mediated taurocholic acid uptake.

, 2019
The experiments were repeated at least once to obtain IC50 mean ± SD (the inhibition concentration at 50% taurocholic acid uptake).
Karsten Suhre (67967), Noha A. Yousri (1392577), Sook Wah Yee (259951), Kathleen M. Giacomini (259990), Huan-Chieh Chien (130556), Kit Wun Kathy Cheung (7429889), Jason M. Kinchen (7429892), Roshanak Irannejad (5674070), Ling Zou (185293), Marjolein van Borselen (7429886), Adrian Stecula (3838480), Eric Boerwinkle (36288), Bing Yu (237109), Elena V. Feofanova (7429883)   +13 more
core   +1 more source

Combination of Plasma-Based Metabolomics and Machine Learning Algorithm Provides a Novel Diagnostic Strategy for Malignant Mesothelioma

Diagnostics, 2021
Background: Malignant mesothelioma (MM) is an aggressive and incurable carcinoma that is primarily caused by asbestos exposure. However, the current diagnostic tool for MM is still under-developed.
Na Li, Chenxi Yang, Sicheng Zhou, Siyu Song, Yuyao Jin, Ding Wang, Junping Liu, Yun Gao, Haining Yang, Weimin Mao, Zhongjian Chen   +10 more
doaj   +1 more source

Regulatory effects of dandelion flavonoids in LPS-induced immune stress in broilers

Poultry Science
This study investigated the protective effect of dandelion flavonoids (DF) against lipopolysaccharide (LPS)-induced immune stress in broilers. A total of 400 healthy one-day-old Cobb 500 broilers with similar body weight were randomly assigned to five ...
Yue Tian, Xuechang Wang, Xiaofeng Geng, Jiawei Ai, Xuelu Liu, Hui Chen, Keqian Di, Lei Shi, Erying Hao, Dehe Wang, Yifan Chen   +10 more
doaj   +1 more source

Integrated assessment of rifampicin‐mediated induction of transporters and drug‐metabolizing enzymes in a long‐term human liver tissue chip system

Clinical Pharmacology &Therapeutics, EarlyView.
Rifampicin is a prototypical clinical inducer used in drug–drug interaction (DDI) studies. However, the clinical relevance and predictability of rifampicin‐mediated hepatic transporter induction remain poorly defined. Conventional hepatocyte culture models fail to capture clinically relevant regulation of transporters and drug‐metabolizing enzymes ...
Mattie E. Hartauer, Raeanne M. Lanphier, Shivam Ohri, Jessica Snyder, Jacqueline B. Tiley, John K. Fallon, Henry Ho, Murat Cirit, Shiny Amala Priya Rajan, Kim L. R. Brouwer   +9 more
wiley   +1 more source

Evaluation of the 3 alpha-hydroxysteroid dehydrogenase assay for ursodeoxycholic acid, and 7 oxo- and 12 oxo- bile acids

Journal of Lipid Research, 1980
3 alpha-Hydroxysteroid dehydrogenase (SDH) quantifies ursodeoxycholic acid, 3 alpha,12 alpha-diol-7-one-5 beta-cholanoic acid, 3 alpha-ol-7-one-5 beta-cholanoic acid, and 3 alpha,7 alpha-diol-12-one-5 beta-cholanoic acid in a manner similar to the more ...
L J Haeffner, S J Gordon, J S Magen, O D Kowlessar   +3 more
doaj   +1 more source