Results 11 to 20 of about 6,894 (164)

Validation of NBD-coupled taurocholic acid for intravital analysis of bile acid transport in liver and kidney of mice [PDF]

EXCLI Journal : Experimental and Clinical Sciences
Fluorophore-coupled bile acids (BA) represent an important tool for intravital analysis of BA flux in animal models of cholestatic diseases. However, addition of a fluorophore to a BA may alter transport properties. We developed and validated a 4-chloro-
Ahmed Ghallab, Sebastian Kunz, Celine Drossel, Veronica Billo, Adrian Friebel, Mats Georg, Richard Göttlich, Zaynab Hobloss, Reham Hassan, Maiju Myllys, Abdel-latief Seddek, Noha Abdelmageed, Paul A. Dawson, Erik Lindström, Stefan Hoehme, Jan G. Hengstler, Joachim Geyer   +16 more
doaj   +2 more sources

FDX1-mediated cuproptosis promotes cholestatic liver injury exacerbated by taurocholic acid-enhanced copper accumulation [PDF]

Cell Death Discovery
Cholestatic liver injury, characterized by direct exposure of hepatocytes to retained bile components with elevated concentrations, represents a common manifestation of various hepatobiliary disorders with persistent threats to long-term patient survival
Yujun Guo, Min Yang, Shengbo Sun, Zhaohua Zhong, Wenjun Lu, Ze’nan Zhang, Meili Fan, Aodan Zhang, Tingting Zhang, Yang Wu, Zhou Li, Zuwei Liu, Qijun Sun, Zhaozhu Li, Qingbo Cui   +14 more
doaj   +2 more sources

Neo-BCV: A Novel Bacterial Complex Vaccine Reshaping the Gut Microbiota to Enhance the Antitumor Immune Response [PDF]

Vaccines
Background: Lung cancer is the most common malignancy worldwide and has the highest mortality rate. Although therapeutic approaches have improved over recent years, the clinical efficacy of lung cancer treatment remains limited.
Hairu Yang, Huiqin Zhu, Zilong Zhu, Lingyun Man, Qingfeng Pang, Tao Lu, Kecheng Xu, Zhenyi Wang, Peihua Lu   +8 more
doaj   +2 more sources

High taurocholic acid concentration induces ferroptosis by downregulating FTH1 expression in intrahepatic cholestasis of pregnancy [PDF]

BMC Pregnancy and Childbirth
Background Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disorder associated with pregnancy and is usually diagnosed based on high serum bile acid. However, the pathogenesis of ICP is unclear.
Wei-jian Zeng, Hua-jing Yang, Ying-jie Gu, Meng-nan Yang, Meng-ru Sun, Sheng-kai Cheng, Yan-yan Hou, Wei Gu   +7 more
doaj   +2 more sources

Improving intestinal absorption and oral bioavailability of curcumin via taurocholic acid-modified nanostructured lipid carriers [PDF]

International Journal of Nanomedicine, 2017
Cihui Tian,1 Sajid Asghar,2 Yifan Wu,1 Zhipeng Chen,3 Xin Jin,1 Lining Yin,1 Lin Huang,1 Qineng Ping,1 Yanyu Xiao1 1Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China; 2Faculty of ...
Tian C, Asghar S, Wu Y, Chen Z, Jin X, Yin L, Huang L, Ping Q, Xiao Y   +8 more
doaj   +2 more sources

Male lake char release taurocholic acid as part of a mating pheromone

Journal of Experimental Biology
ABSTRACT The evolutionary origins of sexual preferences for chemical signals remain poorly understood, due, in part, to scant information on the molecules involved. In the current study, we identified a male pheromone in lake char (Salvelinus namaycush) to evaluate the hypothesis that it exploits a non-sexual preference for juvenile ...
Tyler J. Buchinger, Ke Li, Ugo Bussy, Belinda Huerta, Sonam Tamrakar, Nicholas S. Johnson, Weiming Li   +6 more
openaire   +3 more sources

UPLC-QqQ-MS/MS-based Quantitative Analysis on Bile Acid in Hyperthyroidism Rats to Explore the Effects of Ginseng Herbs [PDF]

Zhipu Xuebao, 2023
A method of ultra-performance liquid chromatography-triple quadrupole tandem mass spectrometry (UPLC-QqQ-MS/MS) was developed to determine the contents of deoxycholic acid, chenodeoxycholic acid, hyodeoxycholic acid, cholic acid, glycinecholic acid ...
LIU Lin-lin, JIN Mo-zhu, DOU De-qiang
doaj   +1 more source

Baat Gene Knockout Alters Post-Natal Development, the Gut Microbiome, and Reveals Unusual Bile Acids in Mice

Journal of Lipid Research, 2022
Bile acids (BAs) are steroid detergents in bile that contribute to fat absorption, cell signaling, and microbiome interactions. The final step in their synthesis is amino acid conjugation with either glycine or taurine in the liver by the enzyme bile ...
Kerri A. Neugebauer, Maxwell Okros, Douglas V. Guzior, Jeremiah Feiner, Nicholas J. Chargo, Madison Rzepka, Anthony L. Schilmiller, Sandra O’Reilly, A. Daniel Jones, Victoria E. Watson, James P. Luyendyk, Laura R. McCabe, Robert A. Quinn   +12 more
doaj   +1 more source

Hepatitis D Virus Entry Inhibitors Based on Repurposing Intestinal Bile Acid Reabsorption Inhibitors

Viruses, 2021
Identification of Na+/taurocholate co-transporting polypeptide (NTCP) as high-affinity hepatic entry receptor for the Hepatitis B and D viruses (HBV/HDV) opened the field for target-based development of cell-entry inhibitors. However, most of the HBV/HDV
Michael Kirstgen, Kira Alessandra Alicia Theresa Lowjaga, Simon Franz Müller, Nora Goldmann, Felix Lehmann, Dieter Glebe, Karl-Heinz Baringhaus, Joachim Geyer   +7 more
doaj   +1 more source

Uptake of Taurocholic Acid into Isolated Rat‐Liver Cells [PDF]

European Journal of Biochemistry, 1975
Binding and transport characteristics for uptake of taurocholic acid by isolated rat liver cells were studied. An adsorption of taurocholate to the cell surface is terminated in less than 15 s. A Ks of 0.55 mM and a total binding capacity of 3.8 nmol/mg cell protein is determined.
L R, Schwarz, R, Burr, M, Schwenk, E, Pfaff, H, Greim   +4 more
openaire   +2 more sources