Results 11 to 20 of about 6,842 (160)

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression [PDF]

Advanced Science
Major Depressive Disorder (MDD) is characterized by abnormal metabolic profiles along the microbiome‐gut‐brain axis. Bile acids (BAs), a class of steroid compounds regulated by the host and microbes, are increasingly shown to become dysregulated in ...
Xiaoying Cai, Taipeng Sun, Mengzhen Feng, Gang Chen, Junchi Zhou, Hong Zhuang, Dan Wang, Ying Chen, Zhen Cheng, Zhi Xu, Xiao Zheng, Xueli Zhang, Yonggui Yuan   +12 more
doaj   +6 more sources

Taurocholic Acid and Glycocholic Acid Inhibit Inflammation and Activate Farnesoid X Receptor Expression in LPS-Stimulated Zebrafish and Macrophages [PDF]

Molecules, 2023
A hyperactive immune response can be observed in patients with bacterial or viral infection, which may lead to the overproduction of proinflammatory cytokines, or “cytokine storm”, and a poor clinical outcome. Extensive research efforts have been devoted
Xutao Ge, Shaoze Huang, Can Ren, Lu Zhao
doaj   +4 more sources

Taurocholic acid promotes hepatic stellate cell activation via S1PR2/p38 MAPK/YAP signaling under cholestatic conditions [PDF]

Clinical and Molecular Hepatology, 2023
Background/Aims Disrupted bile acid regulation and accumulation in the liver can contribute to progressive liver damage and fibrosis. However, the effects of bile acids on the activation of hepatic stellate cells (HSCs) remain unclear.
Jing Yang, Xujiao Tang, Zhu Liang, Mingzhu Chen, Lixin Sun   +4 more
doaj   +2 more sources

RETRACTED: Mancinelli et al. The Effects of Taurocholic Acid on Biliary Damage and Liver Fibrosis Are Mediated by Calcitonin-Gene-Related Peptide Signaling. Cells 2022, 11, 1591 [PDF]

Cells
The journal retracts the article titled “The Effects of Taurocholic Acid on Biliary Damage and Liver Fibrosis Are Mediated by Calcitonin-Gene-Related Peptide Signaling” [...]
Romina Mancinelli, Ludovica Ceci, Lindsey Kennedy, Heather Francis, Vik Meadows, Lixian Chen, Guido Carpino, Konstantina Kyritsi, Nan Wu, Tianhao Zhou, Keisaku Sato, Luigi Pannarale, Shannon Glaser, Sanjukta Chakraborty, Gianfranco Alpini, Eugenio Gaudio, Paolo Onori, Antonio Franchitto   +17 more
doaj   +2 more sources

Taurocholic acid induces intrahepatic cholangiocyte cell proliferation via activating NRAS and YAP1 [PDF]

PLoS ONE
Biliary atresia is a neonatal cholangiopathy characterized by loss of the extrahepatic bile duct causing bile acid accumulation in the liver and subsequent fibro inflammation and abnormal proliferation of intrahepatic ducts.
Lum Fube, Arul Thason, Elizabeth Taliaferro, Carol Heckman, Surya Amarachintha   +4 more
doaj   +3 more sources

Regulatory effects of dandelion flavonoids in LPS-induced immune stress in broilers [PDF]

Poultry Science
This study investigated the protective effect of dandelion flavonoids (DF) against lipopolysaccharide (LPS)-induced immune stress in broilers. A total of 400 healthy one-day-old Cobb 500 broilers with similar body weight were randomly assigned to five ...
Yue Tian, Xuechang Wang, Xiaofeng Geng, Jiawei Ai, Xuelu Liu, Hui Chen, Keqian Di, Lei Shi, Erying Hao, Dehe Wang, Yifan Chen   +10 more
doaj   +2 more sources

Integrating Untargeted Metabolomics and Transcriptomics in Mice with Pulmonary Tuberculosis to Reveal Changes in Linoleic Acid and Its Metabolism in Lung Monocyte-Derived Macrophages [PDF]

Pathogens
Pulmonary tuberculosis (TB) remains a major global health challenge. The molecular and metabolic responses of monocyte-derived macrophages (MDMs), which are critical for host defense against Mycobacterium tuberculosis (Mtb), are not fully characterized ...
Yuxia Sha, Xiaoman Zhao, Hongying Zhu, Ye Li, Meilin Shao, Shenggang Ding, Haoquan Zhou   +6 more
doaj   +2 more sources

FXR‐Mediated Atherosclerosis Alleviation by B. animalis F1‐7 Through Bile Acid Metabolism‐Driven Gut–Liver Axis Modulation

Food Frontiers
This study investigates the mechanisms of B. animalis F1‐7 improving atherosclerosis (AS) through bile acid metabolism by using an “antibiotic cocktail” approach in AS model mice. It was found that B.
Tianhu Shan, Jiawen Wang, Yanyang Liu, Huaqi Zhang, Zhe Zhang, Lanwei Zhang, Hui Liang, Xi Liang   +7 more
doaj   +2 more sources

Taurocholic acid is an active promoting factor, not just a biomarker of progression of liver cirrhosis: evidence from a human metabolomic study and in vitro experiments [PDF]

BMC Gastroenterology, 2018
Background Previous studies have indicated that bile acid is associated with progression of liver cirrhosis. However, the particular role of specific bile acid in the development of liver cirrhosis is not definite.
Zhimin Liu, Zhifeng Zhang, Mei Huang, Xiaoping Sun, Bojia Liu, Qiyang Guo, Qingshan Chang, Zhijun Duan   +7 more
doaj   +2 more sources

Validation of NBD-coupled taurocholic acid for intravital analysis of bile acid transport in liver and kidney of mice [PDF]

EXCLI Journal : Experimental and Clinical Sciences
Fluorophore-coupled bile acids (BA) represent an important tool for intravital analysis of BA flux in animal models of cholestatic diseases. However, addition of a fluorophore to a BA may alter transport properties. We developed and validated a 4-chloro-
Ahmed Ghallab, Sebastian Kunz, Celine Drossel, Veronica Billo, Adrian Friebel, Mats Georg, Richard Göttlich, Zaynab Hobloss, Reham Hassan, Maiju Myllys, Abdel-latief Seddek, Noha Abdelmageed, Paul A. Dawson, Erik Lindström, Stefan Hoehme, Jan G. Hengstler, Joachim Geyer   +16 more
doaj   +2 more sources