Results 21 to 30 of about 6,842 (160)

FDX1-mediated cuproptosis promotes cholestatic liver injury exacerbated by taurocholic acid-enhanced copper accumulation [PDF]

Cell Death Discovery
Cholestatic liver injury, characterized by direct exposure of hepatocytes to retained bile components with elevated concentrations, represents a common manifestation of various hepatobiliary disorders with persistent threats to long-term patient survival
Yujun Guo, Min Yang, Shengbo Sun, Zhaohua Zhong, Wenjun Lu, Ze’nan Zhang, Meili Fan, Aodan Zhang, Tingting Zhang, Yang Wu, Zhou Li, Zuwei Liu, Qijun Sun, Zhaozhu Li, Qingbo Cui   +14 more
doaj   +2 more sources

Neo-BCV: A Novel Bacterial Complex Vaccine Reshaping the Gut Microbiota to Enhance the Antitumor Immune Response [PDF]

Vaccines
Background: Lung cancer is the most common malignancy worldwide and has the highest mortality rate. Although therapeutic approaches have improved over recent years, the clinical efficacy of lung cancer treatment remains limited.
Hairu Yang, Huiqin Zhu, Zilong Zhu, Lingyun Man, Qingfeng Pang, Tao Lu, Kecheng Xu, Zhenyi Wang, Peihua Lu   +8 more
doaj   +2 more sources

Ionomycin Exhibits Potent and Selective Bactericidal Activity Against Clostridioides difficile Through Calcium-Dependent Membrane Disruption. [PDF]

Microbiologyopen
Ionomycin exhibits potent and selective bactericidal activity against Clostridioides difficile, rapidly reducing vegetative cells, toxin production, sporulation, and spore germination while sparing representative gut microbiota. Its activity is calcium‐dependent and mediated through disruption of bacterial membrane potential, highlighting ionomycin as ...
Abouelkhair AA, Abutaleb NS, Seleem MN.
europepmc   +2 more sources

High taurocholic acid concentration induces ferroptosis by downregulating FTH1 expression in intrahepatic cholestasis of pregnancy [PDF]

BMC Pregnancy and Childbirth
Background Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disorder associated with pregnancy and is usually diagnosed based on high serum bile acid. However, the pathogenesis of ICP is unclear.
Wei-jian Zeng, Hua-jing Yang, Ying-jie Gu, Meng-nan Yang, Meng-ru Sun, Sheng-kai Cheng, Yan-yan Hou, Wei Gu   +7 more
doaj   +2 more sources

Dysbiosis in the Gut-Liver Axis Is Associated With Low Bone Mass During Murine Cholestasis. [PDF]

FASEB J
Dysbiosis in the gut‐liver axis drives a dysregulation in bile acid metabolism that increases bile acid efflux into systemic circulation and the bone marrow. Bile acid signaling in the marrow promotes osteoclastogenesis and suppresses osteoblastogenesis, which drives bone loss during cholestatic liver disease in mice. ABSTRACT The gut‐liver axis is the
Hutchison B, Fornsaglio J, Case R, Cornuet P, Qin FY, Ma X, Nejak-Bowen K, Carson MD.   +7 more
europepmc   +2 more sources

Improving intestinal absorption and oral bioavailability of curcumin via taurocholic acid-modified nanostructured lipid carriers [PDF]

International Journal of Nanomedicine, 2017
Cihui Tian,1 Sajid Asghar,2 Yifan Wu,1 Zhipeng Chen,3 Xin Jin,1 Lining Yin,1 Lin Huang,1 Qineng Ping,1 Yanyu Xiao1 1Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China; 2Faculty of ...
Tian C, Asghar S, Wu Y, Chen Z, Jin X, Yin L, Huang L, Ping Q, Xiao Y   +8 more
doaj   +2 more sources

UPLC-QqQ-MS/MS-based Quantitative Analysis on Bile Acid in Hyperthyroidism Rats to Explore the Effects of Ginseng Herbs [PDF]

Zhipu Xuebao, 2023
A method of ultra-performance liquid chromatography-triple quadrupole tandem mass spectrometry (UPLC-QqQ-MS/MS) was developed to determine the contents of deoxycholic acid, chenodeoxycholic acid, hyodeoxycholic acid, cholic acid, glycinecholic acid ...
LIU Lin-lin, JIN Mo-zhu, DOU De-qiang
doaj   +1 more source

Taurocholic acid metabolism by gut microbes and colon cancer. [PDF]

Gut Microbes, 2016
Colorectal cancer (CRC) is one of the most frequent causes of cancer death worldwide and is associated with adoption of a diet high in animal protein and saturated fat. Saturated fat induces increased bile secretion into the intestine. Increased bile secretion selects for populations of gut microbes capable of altering the bile acid pool, generating ...
Ridlon JM, Wolf PG, Gaskins HR.
europepmc   +3 more sources

Baat Gene Knockout Alters Post-Natal Development, the Gut Microbiome, and Reveals Unusual Bile Acids in Mice

Journal of Lipid Research, 2022
Bile acids (BAs) are steroid detergents in bile that contribute to fat absorption, cell signaling, and microbiome interactions. The final step in their synthesis is amino acid conjugation with either glycine or taurine in the liver by the enzyme bile ...
Kerri A. Neugebauer, Maxwell Okros, Douglas V. Guzior, Jeremiah Feiner, Nicholas J. Chargo, Madison Rzepka, Anthony L. Schilmiller, Sandra O’Reilly, A. Daniel Jones, Victoria E. Watson, James P. Luyendyk, Laura R. McCabe, Robert A. Quinn   +12 more
doaj   +1 more source

Discovery of Taurocholic Acid Sodium Hydrate as a Novel Repurposing Drug for Intervertebral Disc Degeneration by Targeting MAPK3 [PDF]

Orthopaedic Surgery
Ping Li, Xiuhua Wu, Peng Li
exaly   +2 more sources