Results 41 to 50 of about 27,297 (261)
Advanced Science, EarlyView.The microalgae‐nanoparticle hybrid system with antibacterial activity can improve the oral delivery and therapeutic efficiency for hepatic encephalopathy treatment. Oral administration of the system can reduced systemic ammonia levels, enhanced intestinal barrier function, attenuated systemic and neuroinflammation, ameliorated cognitive impairments ...
Kaiyue Wang +8 more
wiley +1 more source
Mechanical Flexibility Enables DNA Origami to Overcome Steric Confinement in Mucus
Advanced Science, EarlyView.Mechanical flexibility is introduced as a design parameter to enhance nanocarrier transport in mucus. Using DNA origami, flexibility is decoupled from size, shap and surface chemistry, revealing improved passage through confined hydrogel networks. While surface passivation reduces aggregation, flexibility further boosts transport, offering a general ...
Matteo Tollemeto +5 more
wiley +1 more source
Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies
Advanced Science, EarlyView.This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang +7 more
wiley +1 more source
Evolution of the bile salt nuclear receptor FXR in vertebrates*s⃞
Journal of Lipid Research, 2008 Bile salts, the major end metabolites of cholesterol, vary significantly in structure across vertebrate species, suggesting that nuclear receptors binding these molecules may show adaptive evolutionary changes.
Erica J. Reschly +6 more
doaj +1 more source
Gastroenterology Review, 2021 Pruritus commonly occurs in patients with cholestatic liver diseases. Pruritus that is refractory to pharmacological treatment may be an indication for liver transplantation [1–3]. Pathogenesis of hepatic pruritus is still not fully understood.
Magdalena Antoszewska +3 more
doaj +1 more source
Dependence of the biliary excretion of iopanoic acid on bile salts
Gastroenterology, 1978 Abstract Iopanoic acid is an iodinated organic acid used extensively as a radiographic contrast material for oral cholecystography. Like bilirubin, it is conjugated predominately with glucuronic acid in the liver, and the biliary excretion is enhanced by the concomitant biliary excretion of bile salts.
P M, Loeb, J L, Barnhart, R N, Berk
openaire +2 more sources
Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential
Angewandte Chemie International Edition, EarlyView.Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber +4 more
wiley +1 more source
Perinatal bile acid metabolism: analysis of urinary bile acids in pregnant women and newborns
Journal of Lipid Research, 1997 The metabolism of bile acids in 30 pregnant women was evaluated by analyzing the urinary composition of bile acids during late gestation (weeks 30-41) and again in these women and their newborn infants during the first week after delivery.
A Kimura +9 more
doaj +1 more source
Animal Research and One Health, EarlyView.Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang +6 more
wiley +1 more source
Bile salt hydrolase catalyses formation of amine-conjugated bile acids
NatureAbstract Bacteria in the gastrointestinal tract produce amino acid bile acid amidates that can affect host-mediated metabolic processes 1–6 ; however, the bacterial gene(s) responsible for their production remain unknown.
Bipin Rimal +29 more
openaire +2 more sources