Results 1 to 10 of about 139,121 (234)

Intrahepatic cholestasis of pregnancy

Canadian Medical Association Journal, 2022
Intrahepatic cholestasis of pregnancy is a liver disorder that occurs in pregnant women. Cholestasis is a condition that impairs the release of a digestive fluid called bile from liver cells.
Joanna Girling, C. Knight, Lucy Chappell
semanticscholar   +4 more sources

Da-Chai-Hu-Tang Protects From Acute Intrahepatic Cholestasis by Inhibiting Hepatic Inflammation and Bile Accumulation via Activation of PPARα

Frontiers in Pharmacology, 2022
Cholestasis is caused by intrahepatic retention of excessive toxic bile acids and ultimately results in hepatic failure. Da-Chai-Hu-Tang (DCHT) has been used in China to treat liver and gallbladder diseases for over 1800 years. Here, we demonstrated that
Shihao Xu, Xi Qiao, Peike Peng, Ziyi Zhu, Yaoting Li, Yaoting Li, Mengyuan Yu, Mengyuan Yu, Long Chen, Yin Cai, Jin Xu, Xinwei Shi, Christopher G. Proud, Christopher G. Proud, Jianling Xie, Jianling Xie, Kaikai Shen   +16 more
doaj   +2 more sources

Persistent intrahepatic cholestasis secondary to multiple etiologies: a case report [PDF]

Frontiers in Medicine
Intrahepatic cholestasis may arise from multiple etiologies, but it is particularly challenging to identify its primary etiology, especially when several potential contributors overlap and the disease itself progresses over time.
Ran Wang, Yiyang Shang, Yiyang Shang, Cai’e Wang, Cai’e Wang, Yanhong Gao, Wenxiu Zhang, Fangbo Gao, Fangbo Gao, Yang Guo, Baocheng Deng, Wenwen Zhang, Xingshun Qi   +12 more
doaj   +2 more sources

Perinatal outcomes of intrahepatic cholestasis during pregnancy: An 8-year case-control study.

PLoS ONE, 2020
INTRODUCTION:Previous studies of fetal effects have suggested that intrahepatic cholestasis of pregnancy is associated with a higher rate of adverse neonatal outcomes including preterm birth, neonatal respiratory distress syndrome, meconium-stained ...
Chloé Arthuis, Caroline Diguisto, Henri Lorphelin, Vincent Dochez, Emmanuel Simon, Franck Perrotin, Norbert Winer   +6 more
doaj   +2 more sources

Case Report: Recurrent intrahepatic cholestasis: two rare cases with their novel variants of ATB8B1 and atypical clinical findings [PDF]

Frontiers in Medicine
Recurrent intrahepatic cholestasis type 1 (RIC1), historically also known as BRIC 1 (benign recurrent intrahepatic cholestasis typr 1),is an autosomal recessive disorder presenting with intermittent episodes of cholestatic jaundice and caused by ...
Jiaxun Li, Jiaxun Li, Qi Wei, Sicong Liu, Luyu Lv, Huarong Ding, Liping Guo, Liping Guo, Diefei Hu, Qiuyue Ning   +9 more
doaj   +2 more sources

EVALUATION OF RISK FACTORS FOR INTRAHEPATIC CHOLESTASIS OF PREGNANCY IN PATIENTS PRESENTING TO A TERTIARY CARE CENTRE

Pakistan Armed Forces Medical Journal, 2021
Objectives: To evaluate the principal risk factors associated with development of intrahepatic cholestasis of pregnancy (ICP) in patients presenting to a tertiary care hospital. Study Design: Case control study.
Rabiah Anwar, Kashif Razzaq, Aysha Shahid, Afeera Afsheen, Amera Tariq, Irum Saleem   +5 more
doaj   +3 more sources

Congenital thrombophilia associated with intrahepatic cholestasis of pregnancy. A case report [PDF]

Folia Medica, 2022
Intrahepatic cholestasis of pregnancy is pregnancy-specific liver disorder, characterized by pruritus as the main clinical symptom, and fasting liver function tests.
Corina Iliadi-Tulbure, Maria Cemortan, Cristina Bubulici, Mihaela Botnari-Gutu, Olga Cernetchi   +4 more
doaj   +3 more sources

Gut microbiota alters host bile acid metabolism to contribute to intrahepatic cholestasis of pregnancy

Nature Communications, 2023
Intrahepatic cholestasis of pregnancy (ICP) is a female pregnancy-specific disorder that is characterized by increased serum bile acid and adverse fetal outcomes.
Bo Tang, Li Tang, Sheng-Peng Li, Shuang Liu, Jia-Lin He, Pan Li, Sumin Wang, Min Yang, Longhui Zhang, Yuan-Yuan Lei, Dian-Ji Tu, Xue-Feng Tang, Hua Hu, Qin Ouyang, Xia Chen, Shiming Yang   +15 more
semanticscholar   +1 more source

Interim results from an ongoing, open-label, single-arm trial of odevixibat in progressive familial intrahepatic cholestasis

JHEP Reports, 2023
Background & Aims PEDFIC 2, an ongoing, open-label, 72-week study, evaluates odevixibat, an ileal bile acid transporter inhibitor, in patients with progressive familial intrahepatic cholestasis.
Richard J. Thompson, R. Artan, U. Baumann, P. Calvo, P. Czubkowski, B. Dalgıç, L. D’Antiga, A. Di Giorgio, Özlem Durmaz, E. Gonzales, T. Grammatikopoulos, G. Gupte, W. Hardikar, R. Houwen, B. Kamath, S. Karpen, F. Lacaille, A. Lachaux, E. Lainka, K. Loomes, C. Mack, J. Mattsson, P. McKiernan, Q. Ni, H. Özen, Sanjay Rajwal, B. Roquelaure, E. Shteyer, E. Sokal, R. Sokol, Nisreen Soufi, E. Sturm, M. Tessier, Wendy L. van der Woerd, H. Verkade, Jennifer M. Vittorio, Terese Wallefors, N. Warholic, Qi-Feng Yu, Patrick Horn, L. Kjems   +40 more
semanticscholar   +1 more source

Molecular and Clinical Links between Drug-Induced Cholestasis and Familial Intrahepatic Cholestasis

International Journal of Molecular Sciences, 2023
Idiosyncratic Drug-Induced Liver Injury (iDILI) represents an actual health challenge, accounting for more than 40% of hepatitis cases in adults over 50 years and more than 50% of acute fulminant hepatic failure cases.
G. Vitale, A. Mattiaccio, A. Conti, S. Berardi, V. Vero, Laura Turco, M. Seri, M. Morelli   +7 more
semanticscholar   +1 more source