Results 1 to 10 of about 18,220 (116)

Persistent intrahepatic cholestasis secondary to multiple etiologies: a case report [PDF]

Frontiers in Medicine
Intrahepatic cholestasis may arise from multiple etiologies, but it is particularly challenging to identify its primary etiology, especially when several potential contributors overlap and the disease itself progresses over time.
Ran Wang, Yiyang Shang, Yiyang Shang, Cai’e Wang, Cai’e Wang, Yanhong Gao, Wenxiu Zhang, Fangbo Gao, Fangbo Gao, Yang Guo, Baocheng Deng, Wenwen Zhang, Xingshun Qi   +12 more
doaj   +2 more sources

Genome-wide meta-analysis identifies genetic drivers of bile acid metabolism in intrahepatic cholestasis of pregnancy [PDF]

Nature Communications
Intrahepatic cholestasis of pregnancy, which affects 0.2–2% of pregnancies, is characterized by pruritus, increased aminotransferase activity and elevated serum bile acids. Previous studies have implicated liver-enriched genes in intrahepatic cholestasis
Jaakko S. Tyrmi, Juha Karjalainen, Samvida S. Venkatesh, Clara Benoit-Pilven, Susanna M. Lemmelä, Søren Brunak, Bitten Aagaard, Mie T. Bruun, Christian Erikstrup, Henrik Ullum, Ole B. Pedersen, Karina Banasik, Erik Sørensen, Christina Mikkelsen, Michael Schwinn, Arni Sturluson, Sisse R. Ostrowski, FinnGen, Estonian Biobank research team, DBDS Genomic Consortium, Johannes Kettunen, Henriette Svarre Nielsen, Mette Nyegaard, David Westergaard, Thorunn Rafnar, Patrick Sulem, Kari Stefansson, Priit Palta, Triin Laisk, Taru Tukiainen, Cecilia M. Lindgren, Mark Daly, Aki S. Havulinna, Hannele M. Laivuori   +33 more
doaj   +2 more sources

Case Report: Recurrent intrahepatic cholestasis: two rare cases with their novel variants of ATB8B1 and atypical clinical findings [PDF]

Frontiers in Medicine
Recurrent intrahepatic cholestasis type 1 (RIC1), historically also known as BRIC 1 (benign recurrent intrahepatic cholestasis typr 1),is an autosomal recessive disorder presenting with intermittent episodes of cholestatic jaundice and caused by ...
Jiaxun Li, Jiaxun Li, Qi Wei, Sicong Liu, Luyu Lv, Huarong Ding, Liping Guo, Liping Guo, Diefei Hu, Qiuyue Ning   +9 more
doaj   +2 more sources

EVALUATION OF RISK FACTORS FOR INTRAHEPATIC CHOLESTASIS OF PREGNANCY IN PATIENTS PRESENTING TO A TERTIARY CARE CENTRE

Pakistan Armed Forces Medical Journal, 2021
Objectives: To evaluate the principal risk factors associated with development of intrahepatic cholestasis of pregnancy (ICP) in patients presenting to a tertiary care hospital. Study Design: Case control study.
Rabiah Anwar, Kashif Razzaq, Aysha Shahid, Afeera Afsheen, Amera Tariq, Irum Saleem   +5 more
doaj   +3 more sources

Congenital thrombophilia associated with intrahepatic cholestasis of pregnancy. A case report [PDF]

Folia Medica, 2022
Intrahepatic cholestasis of pregnancy is pregnancy-specific liver disorder, characterized by pruritus as the main clinical symptom, and fasting liver function tests.
Corina Iliadi-Tulbure, Maria Cemortan, Cristina Bubulici, Mihaela Botnari-Gutu, Olga Cernetchi   +4 more
doaj   +3 more sources

Distribution of endotoxin in maternal and fetal body with intrahepatic cholestasis of pregnancy and its association with adverse fetal outcome

BMC Pregnancy and Childbirth, 2022
Background Intrahepatic cholestasis of pregnancy is a pregnancy-specific liver disease. In this study, we sought to explore the distribution of lipopolysaccharide in the maternal body, and its effect on the fetal body in the intrahepatic cholestasis of ...
Xiaomei Huang, Lei Lei, Fan Feng, Yong Shao   +3 more
doaj   +1 more source

Intrahepatic cholestasis of pregnancy and theory of inheritance of the disease. Literature review

The Journal of Maternal-Fetal & Neonatal Medicine, 2023
Intrahepatic cholestasis during pregnancy is associated with a higher risk of prenatal and maternal complications. There are several new publications and guidelines on the detection and thresholds of intrahepatic cholestasis during pregnancy.
Weronika Niemyjska-Dmoch, Przemysław Kosiński, Piotr Węgrzyn, Katarzyna Luterek, Aleksandra Jezela-Stanek   +4 more
doaj   +1 more source

A novel homozygous mutation in the USP53 gene as the cause of benign recurrent intrahepatic cholestasis in children: a case report

The Turkish Journal of Pediatrics, 2023
Background. Benign recurrent intrahepatic cholestasis (BRIC) is a rare cause of cholestasis with recurrent episodes of jaundice and pruritus without extrahepatic bile duct obstruction.
Burcu Berberoğlu Ateş, Ahmet Cevdet Ceylan, Gülin Hızal, Fatih Duran, Hayriye Tatlı Doğan, Şamil Hızlı   +5 more
doaj   +1 more source

Effects of cytomegalovirus infection on the differential diagnosis between biliary atresia and intrahepatic cholestasis in a Chinese large cohort study

Annals of Hepatology, 2021
Introduction and objectives: Differentiating biliary atresia from other causes of neonatal cholestasis is challenging, particularly when cytomegalovirus (CMV) and biliary atresia occur simultaneously.
Dongying Zhao, Xiaohui Gong, Yahui Li, Xiaoang Sun, Yan Chen, Zhaohui Deng, Yongjun Zhang   +6 more
doaj   +1 more source

Da-Chai-Hu-Tang Protects From Acute Intrahepatic Cholestasis by Inhibiting Hepatic Inflammation and Bile Accumulation via Activation of PPARα

Frontiers in Pharmacology, 2022
Cholestasis is caused by intrahepatic retention of excessive toxic bile acids and ultimately results in hepatic failure. Da-Chai-Hu-Tang (DCHT) has been used in China to treat liver and gallbladder diseases for over 1800 years. Here, we demonstrated that
Shihao Xu, Xi Qiao, Peike Peng, Ziyi Zhu, Yaoting Li, Yaoting Li, Mengyuan Yu, Mengyuan Yu, Long Chen, Yin Cai, Jin Xu, Xinwei Shi, Christopher G. Proud, Christopher G. Proud, Jianling Xie, Jianling Xie, Kaikai Shen   +16 more
doaj   +1 more source