Results 1 to 10 of about 20,286 (212)

Aspartic Acid Ameliorates Cholestasis in Bile Duct-Ligated Rats [PDF]

The Egyptian Journal of Histology, 2023
Background: Amino acids are promising agents in a variety of therapeutic fields including proliferation management. D-aspartic acid (DAA) is a non-essential amino acid, which occurs in many marine and terrestrial animals and has alleviative effects ...
Mahmoud Elnagar, Yomna Mahmoud, Mohamed Mohamed   +2 more
doaj   +1 more source

Synthesis and intestinal metabolism of ursodeoxycholic acid conjugate with an antiinflammatory agent, 5-aminosalicylic acid

Journal of Lipid Research, 1998
5-Aminosalicylic acid conjugate of ursodeoxycholic acid was synthesized in above 90% yield by adding a basic solution of 5-aminosalicylic acid into the mixed anhydride formed with ursodeoxycholic acid and ethyl chloroformate.
Ashok K. Batta, G. Stephen Tint, Guorong Xu, Sarah Shefer, Gerald Salen   +4 more
doaj   +1 more source

Ursodeoxycholic acid, chenodeoxycholic acid, and 7-ketolithocholic acid are primary bile acids of the guinea pig.

Journal of Lipid Research, 1990
Guinea pig gallbladder bile contains chenodeoxycholic acid (62 +/- 5%), ursodeoxycholic acid (8 +/- 5%), and 7-ketolithocholic acid (30 +/- 5%). All three bile acids became labeled to the same specific activity within 30 min after [3H]cholesterol was ...
GS Tint, GR Xu, AK Batta, S Shefer, W Niemann, G Salen   +5 more
doaj   +1 more source

Characterization of serum and urinary bile acids in patients with primary biliary cirrhosis by gas-liquid chromatography-mass spectrometry: effect of ursodeoxycholic acid treatment.

Journal of Lipid Research, 1989
We have studied the effect of ursodeoxycholic acid on the serum and urinary bile acids in seven patients with moderate to severe primary biliary cirrhosis.
A K Batta, R Arora, G Salen, G S Tint, D Eskreis, S Katz   +5 more
doaj   +1 more source

Changes in biliary lipid and biliary bile acid composition in patients after administration of ursodeoxycholic acid.

Journal of Lipid Research, 1978
Twenty-three patients with gallstones were treated with two dosage levels of ursodeoxycholic acid, 600 mg/day and 150 mg/day. Two to three months after the treatment, the molar percentage of cholesterol in bile significantly decreased (from 7.4 to 4.5 ...
I Makino, S Nakagawa
doaj   +1 more source

Radioimmunoassay of ursodeoxycholic acid in serum.

Journal of Lipid Research, 1978
A sensitivie and specific radioimmunoassay for the measurement of serum ursodeoxycholic acid has been developed. Ursodeoxycholic acid bound to bovine serum albumin was used as an antigen, and antiserum to this antigen was raised in the rabbit.
I Makino, A Tashiro, H Hashimoto, S Nakagawa, I Yoshizawa   +4 more
doaj   +1 more source

New 6-substituted bile acids: physico-chemical and biological properties of 6 alpha-methyl ursodeoxycholic acid and 6 alpha-methyl-7-epicholic acid.

Journal of Lipid Research, 1994
New analogs of ursodeoxycholic acid and 7-epicholic acid containing a 6 alpha-methyl group were synthesized, and their physico-chemical properties were studied and compared with those of their natural analogs.
A Roda, R Pellicciari, C Cerrè, C Polimeni, B Sadeghpour, M Marinozzi, G C Forti, E Sapigni   +7 more
doaj   +1 more source

Enzyme-linked immunoassay of ursodeoxycholic acid in serum.

Journal of Lipid Research, 1979
A sensitive and specific enzyme-linked immunoassay for the measurement of ursodeoxycholic acid in human serum was developed. Ursodeoxycholic acid conjugated to alkaline phosphatase (from calf intestine) was used as a tracer.
S Ozaki, A Tashiro, I Makino, S Nakagawa, I Yoshizawa   +4 more
doaj   +1 more source

Formation of ursodeoxycholic acid from chenodeoxycholic acid in the human colon: studies of the role of 7-ketolithocholic acid as an intermediate.

Journal of Lipid Research, 1983
The formation of ursodeoxycholic acid from chenodeoxycholic acid and the role of 7-ketolithocholic acid as an intermediate in this biotransformation were studied in vitro in fecal incubations as well as in vivo in the human colon.
H Fromm, R P Sarva, F Bazzoli
doaj   +1 more source

pH-Solubility relations of chenodeoxycholic and ursodeoxycholic acids: physical-chemical basis for dissimilar solution and membrane phenomena.

Journal of Lipid Research, 1980
We examined by titration the electrochemical properties, apparent pK (pK'a), precipitation pH, and undissociated bile acid solubilities of chenodeoxycholic acid and its 7 beta epimer, ursodeoxycholic acid and their glycine conjugates as functions of a ...
H Igimi, M C Carey
doaj   +1 more source