Results 1 to 10 of about 2,524,610 (215)

AI-enabled engineering of hesperidin/ursodeoxycholic acid nanomedicine for synergistic treatment of drug-induced liver injury. [PDF]

Smart Mol
An AI‐driven framework integrating disease‐network analysis, direction‐aware molecular screening, and carrier‐free co‐assembly engineering enables nanomedicine design. The dual‐constraint deep learning model predicts API–target affinity and regulatory direction to prioritize complementary APIs.
Xiao K, Fan M, Zheng H, Gu B, Wang S, Wu Z, Zhang S, Zhao X, Zhang W, Ning Q, A S, Yang C, Sun H, Mo R, Shao D.   +14 more
europepmc   +2 more sources

Formation of urso- and ursodeoxy-cholic acids from primary bile acids by a Clostridium limosum soil isolate.

Journal of Lipid Research, 1984
A gram-positive, rod-shaped anaerobe (isolate F-14) was isolated from soil. This organism was identified by cellular morphology as well as by fermentative and biochemical data as Clostridium limosum.
J D Sutherland, L V Holdeman, C N Williams, I A Macdonald   +3 more
doaj   +1 more source

Development of a technology for a combined hepatoprotective agent

Разработка и регистрация лекарственных средств
Introduction. Hepatoprotectors are one of the broad drug groups used in complex therapy at different stages of liver damage. In clinical practice, hepatoprotective agents are used in form of individual or combined drugs.
I. E. Kauhova, O. N. Abrosimova, B. A. Perez, N. Y. Sipkina, E. K. Novikova, I. E. Smekhova, A. L. Marchenko   +6 more
doaj   +1 more source

Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study

Frontiers in Neuroscience, 2015
Ursodeoxycholic acid and its main conjugate glycoursodeoxycholic acid are bile acids with neuroprotective properties. Our previous studies demonstrated their anti-apoptotic, anti-inflammatory and antioxidant properties in neural cells exposed to ...
Inês ePalmela, Leonor eCorreia, Rui eSilva, Rui eSilva, Hiroyuki eSasaki, Kwang Sik Kim, Dora eBrites, Dora eBrites, Maria A Brito, Maria A Brito   +9 more
doaj   +1 more source

Optimizing the Treatment of Atopic Dermatitis in Infants Using Ursodeoxycholic Acid

Zdorovʹe Rebenka, 2016
We have determined the advisability of including a suspension of ursodeoxycholic acid into the treatment of atopic dermatitis in infants. It is proved that taking a suspension of ursodeoxycholic acid in 25 infants with atopic dermatitis leads to a ...
O.H. Shadrin, H.A. Haiduchyk
doaj   +1 more source

Lipophilicity study of ursodeoxycholic acid

Current Issues in Pharmacy and Medical Sciences, 2012
In this work, the researchers determined the chromatographic parameter of the lipophilicity (RMW) of ursodeoxycholic acid under various chromatographic conditions, and using the RP-TLC and RP-HPTLC methods. This chromatographic analysis was performed on
Małgorzata Dołowy
doaj   +1 more source

Effect of Ursodeoxycholic Acid Alone Verses Ursodeoxycholic Acid and Rifampicin in Obstetric Cholestasis

Pakistan Journal of Medicine and Dentistry
Background: Intrahepatic cholestasis of pregnancy (ICP) is a common liver disorder in pregnancy, associated with pruritus, elevated bile acids, and increased risk of adverse perinatal outcomes.
Ayesha Amjad, Sadia Aftab, Tahreem Sehar, Samana Haider, Tehmina Aziz Qureshi, Kainaat Kanwal   +5 more
doaj   +1 more source

Are Postprandial Bile Acid Levels Helpful in Predicting Perinatal Complications in Patients with Intrahepatic Cholestasis of Pregnancy?

Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2015
Purpose: To determine the outcomes of Iintrahepatic cholestasis of pregnancy and the role of postprandial serum bile acid levels in the prediction of perinatal complications.
Kudret Erkenekli, Can Tekin iskender, Hasan Onur Topcu, Tugba Ensari, Dilek Uygur, Nuri Danisman   +5 more
doaj  

Nor-ursodeoxycholic acid in hepatobiliary diseases: A narrative review. [PDF]

World J Gastrointest Pharmacol Ther
Malakar S, Sood N, Giri S, Samanta A.
europepmc   +1 more source

Neuroprotective effects of ursodeoxycholic acid in Parkinson's disease and Alzheimer's disease. [PDF]

Neuroprotection
Chong AEY, Sasmita AO, Koh RY, Ling APK.
europepmc   +1 more source