Results 41 to 50 of about 28,025 (230)

A randomized double-blind study of the short-time treatment of obese patients with nonalcoholic fatty liver disease with ursodeoxycholic acid [PDF]

, 2003
In order to determine the effect of ursodeoxycholic acid on nonalcoholic fatty liver disease, 30 patients with body mass indices higher than 25, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) or gamma-glutamyltransferase
Lanzoni, Valeria Pereira, Parise, Edison Roberto, Santos, V.n., Shigueoka, David Carlos, Szejnfeld, Jacob   +4 more
core   +3 more sources

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Ursodeoxycholic acid to reduce adverse perinatal outcomes for intrahepatic cholestasis of pregnancy: the PITCHES RCT

Efficacy and Mechanism Evaluation, 2020
Background: Intrahepatic cholestasis of pregnancy, characterised by maternal pruritus and raised serum bile acid concentrations, is associated with increased rates of stillbirth, preterm birth and neonatal unit admission.
Lucy C Chappell, Jennifer L Bell, Anne Smith, Catherine Rounding, Ursula Bowler, Louise Linsell, Edmund Juszczak, Sue Tohill, Amanda Redford, Peter H Dixon, Jenny Chambers, Rachael Hunter, Jon Dorling, Catherine Williamson, Jim G Thornton   +14 more
doaj   +1 more source

Pharmacological interventions for primary sclerosing cholangitis: an attempted network meta-analysis. [PDF]

, 2017
BACKGROUND: Primary sclerosing cholangitis is a chronic cholestatic liver disease that is associated with both hepatobiliary and colorectal malignancies, which can result in liver cirrhosis and its complications. The optimal pharmacological treatment for
Davidson, Brian R, Gurusamy, Kurinchi Selvan, Hawkins, Neil, Saffioti, Francesca, Thorburn, Douglas, Toon, Clare D, Tsochatzis, Emmanuel   +6 more
core   +4 more sources

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Experience of Using Ursodeoxycholic Acid in Children with Organic Diseases of the Liver

Zdorovʹe Rebenka, 2015
The mechanisms of ursodeoxycholic acid effects on the human body, the findings of clinical studies and observations on the use of ursodeoxycholic acid preparation for the treatment of children with organic diseases of the liver were considered.
Ye.N. Babadzhanian
doaj   +1 more source

Ursodeoxycholic acid augmentation in treatment-refractory schizophrenia: a case report

Journal of Medical Case Reports, 2020
Background Treatment-resistance is recognized as a significant dilemma in schizophrenia, which has been reported to involve approximately one-third of patients with schizophrenia.
Mohsen Khosravi
doaj   +1 more source

The Role of the Gut Microbiota in Allogeneic Hematopoietic Cell Transplantation

American Journal of Hematology, EarlyView.
ABSTRACT Allogeneic hematopoietic cell transplantation (allo‐HCT) is an effective treatment for patients with high‐risk hematologic malignancies. Over the last decade, gut microbiota composition during allo‐HCT has been associated with patients' outcomes.
Wenjing Hao, Nicolas Stocker, Béatrice Gaugler, Mohamad Mohty, Florent Malard   +4 more
wiley   +1 more source

Ursodeoxycholic acid alleviates Xanthium Strumarium induced hepatic and renal toxicity in rats by inhibiting mitochondrial pore opening

Revista Científica
In Xanthium strumarium toxicity, mitochondrial dysfunction resulting from the opening of mitochondrial pores is identified as the primary mechanism responsible for liver and kidney damage.
Zeliha Keskin Alkaç, Fatih Ahmet Korkak, Gürdal Dağoğlu, Yesari Eröksüz, Sadettin Tanyıldızı   +4 more
doaj   +1 more source

Impact of ursodeoxycholic acid on circulating lipid concentrations: a systematic review and meta-analysis of randomized placebo-controlled trials

Lipids in Health and Disease, 2019
Objective The aim of this meta-analysis of randomized placebo-controlled trials was to examine whether ursodeoxycholic acid treatment is an effective lipid-lowering agent.
Luis E. Simental-Mendía, Mario Simental-Mendía, Adriana Sánchez-García, Maciej Banach, Maria-Corina Serban, Arrigo F. G. Cicero, Amirhossein Sahebkar   +6 more
doaj   +1 more source