Results 41 to 50 of about 44,623 (260)

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Natural killer cell-mediated shedding of ULBP2. [PDF]

PLoS ONE, 2014
UL16 binding proteins (ULBPs) are a family of cell surface proteins that are present in transformed and stressed cells and ligands for NKG2D. Soluble NKG2D ligands have been found in sera from cancer patients with their protein concentrations correlated ...
Ruipeng Wang, Peter D Sun
doaj   +1 more source

Human serum-mediated cytolysis of SUVECs.

, 2013
SUVECs from non-Tg (n = 2) and Tg (n = 7) were incubated for 6 h in MEM culture medium containing serial dilutions of normal human serum. Cytolysis rate was calculated based on the counts of live and dead cells.
In-Sung Hwang (582963), Sang-Hwan Hyun (295152), Gun-Hyuk Jang (582962), Yu-Kyung Kim (582964), Eui-Bae Jeung (295151), Yeon-woo Jeong (5659531), Woo-Suk Hwang (582965), Yeun-Ik Jeong (295147), Nam-Hyung Kim (293371), Chi-Hun Park (295145), Young-Hee Jeong (582961), Taeyoung Shin (295150)   +11 more
core   +1 more source

Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity [PDF]

, 1979
When deprived of oxygen, Bacille Calmette-Guérin (BCG)-activated macrophages no longer lysed P388 lymphoma cells. Both H2O2 release and cytotoxicity by BCG-activated macrophages and by granulocytes triggered with phorbol myristate acetate (PMA) were ...
Silverstein, Samuel C., S C Silverstein, Cohn, Zanvil A., Nathan, Carl F., Brunker, Linda H., L H Brukner, Z A Cohn, C F Nathan   +7 more
core   +1 more source

Cell‐Based Biohybrid Micro/Nanorobots for Biotherapy

Advanced Robotics Research, EarlyView.
This review systematically evaluates cell‐based biohybrid micro/nanorobots (CB‐BMRs), highlighting their cell selection criteria, fabrication strategies, and diverse actuation modes. Furthermore, it surveys the promising therapeutic applications of CB‐BMRs in targeted cancer, thrombosis, and inflammation treatments, while comprehensively discussing ...
Lin Wang, Chenlu Liu, Yu Zhao, Chuanhua Li, Xuyang Chen, Shixiao Ding, Lizhou Dai, Guokun Wang, Tianlong Li, Jiaxin Li, Xuejia Liu, Haocheng Wang   +11 more
wiley   +1 more source

Acute Drug-Induced Cholestatic Syndrome in Basedow Graves’ Disease

Journal of Interdisciplinary Medicine, 2020
Introduction: Graves’ disease (GD), an autoimmune disorder caused by high levels of auto-antibodies against the thyroid-stimulating hormone receptor, is considered the most common cause of thyrotoxicosis, characterized by features such as goiter ...
Tiucă Robert Aurelian, Boeriu Alina Mioara, Georgescu Rareș Adrian, Pașcanu Ionela Maria   +3 more
doaj   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

Advanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu, Xingwei Xie, Xiaohuan Wu, Suidong Ouyang, Yang Zhou, Kang Wen, Yutong Zhong, Yuyang Chen, Handuo Wang, Yuan Gao, Ling Jiang, Hui Li, Wenli Zhao, Abai Xu, Enguang Bi   +14 more
wiley   +1 more source

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

Wild/Woodland Mushroom Poisoning: The Experience of Bucharest Emergency Hospital-Retrospective Study of ER 2023–2024 Presentations

Journal of Fungi
The global trend of increasing mushroom consumption, combined with traditional practices in Romania and other Eastern European countries of collecting and consuming “wild mushrooms”, may contribute to the rising incidence of emergency presentations due ...
Bogdan Oprita, Mihai Ciprian Neacsu, Bogdan Alexandru Dinu, Ionut Olaru, Ruxandra Oprita   +4 more
doaj   +1 more source