Results 51 to 60 of about 44,623 (260)
Alcoholic liver disease: a modern look at diagnosis and treatment
Медицинский совет, 2019 Alcohol is one of the leading etiological factors in liver damage. In alcoholic liver disease (ALD), hypoxia occurs due to an imbalance between the energy requirement of hepatocytes and energy production in the mitochondrial oxidative phosphorylation ...
R. G. Myazin, D. N. Emel’yanov
doaj +1 more source
THE IMPORTANCE OF ASSESSING INDICATORS OF LIPID METABOLISM IN CHRONIC VIRAL HEPATITIS
Arta Medica, 2023 Introduction. A disorder of lipid metabolism is very often observed in patients with chronic viral hepatitis B and C, which can lead to the progressive damage of the liver parenchyma with future severe evolution of chronic liver pathology.
Tatiana Ghelmici +6 more
doaj +1 more source
Advanced Science, EarlyView.A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Shiqin Jian +14 more
wiley +1 more source
Advanced Science, EarlyView.A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang +8 more
wiley +1 more source
Phorbol ester mediates reversible reduction of cloned T lymphocyte cytolysis.
, 1983 Prolonged contact with nanomole to micromole concentrations of the tumor promoter phorbol myristate acetate causes a significant reduction in the lytic activity of cloned cytolytic T cells.
Bach, F H, Roopenian, D C, Orosz, C G
core +1 more source
Supramolecular Assembly of an Antimicrobial Peptide Into a Pore
Angewandte Chemie, EarlyView.Supramolecular assembly of an AMP is linked to transport across the Staphylococcus aureus membrane. ABSTRACT Antimicrobial peptides (AMPs) have long been ascribed the ability to form pores. These structures, some observed, others inferred, vary in their mechanisms of action, though most are associated with lysis.
Kathyana Deeyagahage +3 more
wiley +2 more sources
Modulation of Reoviral Cytolysis (I): Combination Therapeutics
Viruses, 2023 Patients with stage IV gastric cancer suffer from dismal outcomes, a challenge especially in many Asian populations and for which new therapeutic options are needed.
Yoshinori Mori +6 more
doaj +1 more source
Patient‐Derived Glioblastoma Organoids for AI‐Guided Prediction of Therapeutic Response
Advanced Science, EarlyView.Patient‐derived glioblastoma organoids provide clinically relevant models that preserve tumor heterogeneity and enable integrated AI‐driven analysis of imaging, molecular, and treatment‐response data. Their convergence with advanced analytics supports predictive, personalized therapeutic strategies and may accelerate translation from patient‐specific ...
Sandbhor Puja +15 more
wiley +1 more source
The mechanisms of cytolysis in destructive forms of the periodontitis [PDF]
, 2011 The results of cytolysis marker in saliva of patients with destructive forms of periodontitis are represent. A recent study found the different mechanisms of alterations on destructive forms of periodontitis.Представлены результаты анализа маркеров ...
Arefyeva, J. V. +9 more
core
Advanced Science, EarlyView.Tumor bacterization by fusogenic outer membrane vesicles enhances microbial‐like recognition of tumor cells while activating the TLR4–NF‐κB–NLRC5 axis to upregulate MHC class I expression. By simultaneously strengthening APC sensing and T‐cell recognition, this strategy breaks tumor immune invisibility and promotes more effective antitumor immune ...
Xing Liu +9 more
wiley +1 more source