Results 61 to 70 of about 44,623 (260)
Nested Selves: Self‐Organization and Shared Markov Blankets in Prenatal Development in Humans
Topics in Cognitive Science, EarlyView., 2023 Abstract The immune system is a central component of organismic function in humans. This paper addresses self‐organization of biological systems in relation to—and nested within—other biological systems in pregnancy. Pregnancy constitutes a fundamental state for human embodiment and a key step in the evolution and conservation of our species. While not
Anna Ciaunica +3 more
wiley +1 more source
MHC class I expression protects rat colon carcinoma cells from hepatic natural killer cell-mediated apoptosis and cytolysis, by blocking the perforin/granzyme pathway. [PDF]
, 2002 BACKGROUND: Hepatic natural killer (NK) cells, the most cytotoxic cells of the natural occurring NK cells, are located in the liver sinusoids and are thus in a strategic position to kill arriving metastasising tumour cells, like colon carcinoma cells. It
Vermijlen, David +7 more
core +1 more source
Advanced Science, EarlyView.Routine serial H&E specimens from bladder cancer are converted into paired T0/T1 digital pathology readouts of tumor evolution. Progression is associated with longitudinal nuclear drift, with nuclear size‐related changes most evident in the independent confirmation cohort, alongside a broader spatial burden of increased nuclear area and biological ...
Xing Liu +14 more
wiley +1 more source
Gastroenterologìa, 2013 High levels of morbidity, deterioration in quality of life, increased mortality from complications of chronic liver disease causes socially significant medical problem.
Yu.M. Stepanov +2 more
doaj +1 more source
Antiestrogens modulate the perforin/granzyme pathway of natural killer cell-mediated cytolysis [PDF]
, 1999 Antiestrogenic drugs tamoxifen (TX) and toremifene (TO) are known to augment immune cytolysis in tumor targets induced by various killer cells. Here, we show that antiestrogens are capable of enhancing natural killer (NK) cell-mediated cytotoxicity ...
Haeryfar, Seyed Mohammad Mansour
core
Advanced Science, EarlyView.An active biomaterial‐based bi‐adjuvant nanovaccine restores the immunocompetence of aged dendritic cells to overcome senescent cell tolerance. Accompanied by the downregulation of mitotic kinases Aurka/b and attenuation of senescence‐associated PI3K/AKT phosphorylation, the nanovaccine enhances antigen‐presenting capacity and promotes potent cytotoxic
Qingxu Song +5 more
wiley +1 more source
THE IMPORTANCE OF SEVERE CYTOLYSIS SYNDROME IN HYPERTROPHIC CARDIOMYOPATHY IN CHILDREN [PDF]
Romanian Journal of Pediatrics, 2017 Hypertrophic cardiomyopathy is the second most frequent cardiomyopathy in children and it counts as a genetic disorder for a high number of cases, with widely variable clinical presentation.
Flavia-Cristina Al-AkelFlavia-Cristina Al-Akel +1 more
doaj +1 more source
Cytolysis and Protoplasmic Structure [PDF]
Journal of Experimental Biology, 1925 ABSTRACT The starfish (Asterias forbesii) egg is unusual in that it is very resistant to cytolysis by Quillaja saponin but possesses little resistance to hypotonic solutions (Page and Clowes1). Inasmuch as the point of attack of saponin and hypotonic solutions is quite unknown, the fact that the effect of hypotonic ...
Irvine H. Page, G. H. A. Clowes
openaire +1 more source
, 1992 The adenovirus E1A and E1B proteins are required for transformation of primary rodent cells. When expressed in the absence of the 19,000-dalton (19K) E1B protein, however, the E1A proteins are acutely cytotoxic and induce host cell chromosomal DNA ...
Sabbatini, P. +5 more
core +1 more source
Advanced Science, EarlyView.X‐shaped DNA promotes multivalent cGAS assembly and enhances cGAS‐STING signaling. When conjugated with antigenic peptides, the resulting X‐DNA‐based peptide vaccine promotes dendritic cell activation, antigen presentation, and antitumor T‐cell responses.
Jiabei Li +7 more
wiley +1 more source