Results 81 to 90 of about 44,623 (260)

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Interrelation of cytokine profile and cytolysis in children with chronic virus hepatitis В [PDF]

Саратовский научно-медицинский журнал, 2011
Chronic hepatites for today remain the important problem with children among children»s infections not only in our country, but also all over the world. In clause the immune factors influencing on патогенез of a chronic virus hepatites В at children are ...
Keltsev V.A., Churbakova О.V.
doaj  

Anti-Fas mAb-induced apoptosis and cytolysis of airway tissue eosinophils aggravates rather than resolves established inflammation

Respiratory Research, 2005
Background Fas receptor-mediated eosinophil apoptosis is currently forwarded as a mechanism resolving asthma-like inflammation. This view is based on observations in vitro and in airway lumen with unknown translatability to airway tissues in vivo.
Persson Carl GA, Rydell-Törmänen Kristina, Uller Lena, Erjefält Jonas S   +3 more
doaj   +1 more source

Case Study of a Cross‐Platform Evaluation of an Optimized Multicolor Flow Cytometry Immunophenotyping Assay for Human Peripheral Whole Blood

Cytometry Part A, EarlyView.
ABSTRACT Flow cytometry is a commonly used single‐cell analysis technique that can be applied for the immunophenotyping of human blood samples. Nowadays, increasing numbers of clinical trials include translational research programs utilizing flow‐based immune monitoring assays to assess patients' longitudinal immune status.
Lia Mogge, Udo Gaipl, Stefanie Corradini, Benjamin Frey, Anna‐Jasmina Donaubauer   +4 more
wiley   +1 more source

ON THE MECHANISM OF CYTOLYSIS IN PARAMECIUM [PDF]

Quarterly Journal of Experimental Physiology, 1909
1. The same agents which cause cytolysis in the sea‐urchin egg and the red blood‐corpuscle produce also cytolysis in Paramecium.2. The formation of a membrane is an essential step in this cytolysis The membrane is raised in vesicles by an increase in intracellular osmotic pressure.
openaire   +1 more source

Clinical Translation of Patient‐Derived Organoids: Perspectives for Personalized Therapy in Cancer

International Journal of Cancer, EarlyView.
ABSTRACT Patient‐derived organoids (PDO) are accelerating precision medicine. These biological platforms allow for the autologous in vitro expansion of material from cancer patients in a considerably short period of time. These three‐dimensional models can faithfully recapitulate aspects of tissue heterogeneity, architecture, and relevant cellular ...
Haiyan Yue, Daniele Carchidi, Philipp Schmucker, Roland Seiler, Bernhard Kiss, Catarina Macedo‐Silva, Marianna Kruithof‐de Julio   +6 more
wiley   +1 more source

The role of collecting bladder wash fluid before biopsy procedure to help the cytological diagnosis of residual tumor

Journal of Cytology, 2015
Background: Urinary cytology has low sensitivity and specificity in urinary neoplasm. Aim: We planned to assess whether the examination of bladder washing before biopsy (WBB) plays a role in better cytologic diagnosis of bladder wash fluid collected ...
Aydan Kiliçarslan, Nuran Süngü, Serdar Balci, Erdem Canda, Serkan Altinova, Gülnur Güler   +5 more
doaj   +1 more source

Human Monocyte-Released Cytotoxic Factor: Effect on Various Cellular Functions, and Dependency of Cytolysis on Various Metabolic Processes

, 1986
The ability of the human monocyte-released cytotoxic protein factor(s) (CF) to mediate cytolysis when various metabolic processes in target cells were inhibited, and its effect on various cell functions have been studied.
Jon Nissen-Meyer, Rigmor Austgulen, Odd Kildahl-Andersen   +2 more
core   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Hepatitis B or Hepatitis C Virus Infection Is a Risk Factor for Severe Hepatic Cytolysis after Initiation of a Protease Inhibitor-Containing Antiretroviral Regimen in Human Immunodeficiency Virus-Infected Patients

, 2000
In a cohort of 1,047 human immunodeficiency virus type 1-infected patients started on protease inhibitors (PIs), the incidence of severe hepatic cytolysis (alanine aminotransferase concentration five times or more above the upper limit of the normal ...
Geneviève Chêne, Marianne Savès, François Raffi, Vincent Le Moing, null null, Philippe Morlat, Anne Waldner-Combernoux, Catherine Leport, Bruno Marchou, Catherine Rivière, Philippe Clevenbergh   +10 more
core   +1 more source