Results 91 to 100 of about 44,623 (260)

Disulfidptosis‐ and Ferroptosis‐Related Gene Signatures in Rheumatoid Arthritis: Association Analysis and Diagnostic Model Construction

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint damage. Although ferroptosis has been implicated in RA progression, the role of disulfidptosis and its interaction with ferroptosis remains unclear.
Ting‐Ting Wang, Dong‐Mei Wang, Xue Li, Yuan‐Li Wei, Ping‐Dan Liu, Shi‐Lin Li, Si‐Ying Xiong, Cai‐Zhen Liu, Fan‐Xin Zeng, Jian‐Hong Wu, Lin Tang   +10 more
wiley   +1 more source

SERPINB9 Promotes Colorectal Cancer Liver Metastasis and Immunotherapy Resistance: Association With MHC‐I Downregulation and CD8+ T Cell Dysfunction

Medicine Bulletin, EarlyView.
ABSTRACT Background Colorectal cancer liver metastasis (CRLM) is the leading cause of mortality in colorectal cancer (CRC) patients, for which effective treatments remain limited. The mechanisms by which tumor cells evade immune surveillance and escape cytotoxic killing remain poorly understood.
Xin Liu, Wenchen Wang, Hongqian Wang, Yanshen Kuang, Baoqing Jia   +4 more
wiley   +1 more source

Eosinophil extracellular traps in respiratory ailment: Pathogenic mechanisms and clinical translation

World Journal of Otorhinolaryngology-Head and Neck Surgery
Background Eosinophilic extracellular traps (EETs) are reticular complexes comprising deoxyribonucleic‐Acid (DNA) fibers and granule proteins. Aims EETs play a crucial role in antimicrobial host responses and are pathogenic when overproduced or under ...
Shun‐Yu Wu, Bo‐Yu Cai, Tian‐Yu Wang, Zhi‐Wen Cao, Hu Peng, Huan‐Hai Liu   +5 more
doaj   +1 more source

Spontaneous and induced cytolysis of leukocytes from bovine mammary gland in the course of cultivation in vitro - the correlation with neutrophil granulocytes apoptosis

Veterinární Medicína, 2006
The process of leukocyte cytolysis and the manifestations of apoptosis and secondary necrosis of neutrophil granulocytes (hereafter only "neutrophils") were studied on four virgin heifers after the induction of leukocyte influx into the mammary gland and
D. Rysanek, Z. Sladek, V. Babak, D. Vasickova, M. Hubackova   +4 more
doaj   +1 more source

Image_2_Synergistic Tumor Cytolysis by NK Cells in Combination With a Pan-HDAC Inhibitor, Panobinostat.tif

, 2021
Histone deacetylases (HDAC) are frequently overexpressed in tumors, and their inhibition has shown promising anti-tumor effects. However, the synergistic effects of HDAC inhibition with immune cell therapy have not been fully explored. Natural killer (NK)
Adeleye O. Adeshakin (11358672), Dehong Yan (10340011), Xiaochun Wan (408279), Xuguang Li (103076), Jiacheng Bi (11295609), Lukman O. Afolabi (11358669), Funmilayo O. Adeshakin (11358675), Haisi Wu (10509979), Liang Chen (73736)   +8 more
core   +1 more source

Bioactivity profiling of linear venom peptides from Italian small wood‐scorpion (Euscorpius italicus)

Pest Management Science, EarlyView.
Functional screening pipeline of venom peptides from Euscorpius italicus reveal their activity towards globally important pest insects, bacteria, and cells – providing insight on the potential and function of arachnid venom peptides. Abstract BACKGROUND Rising host‐expansion and the global spread of pest insects, confront agricultural sectors with ...
Maurice Pierry, Ludwig Dersch, Jonas Krämer, Lennart Schulte, Ignazio Avella, Tobias Kessel, Kornelia Hardes, Michael Marner, Jens Grotmann, Maximilian Seip, Till F. Schäberle, Tim Lüddecke   +11 more
wiley   +1 more source

NKG2D Signaling Leads to NK Cell Mediated Lysis of Childhood AML

Journal of Immunology Research, 2015
Natural killer cells have been shown to be relevant in the recognition and lysis of acute myeloid leukemia. In childhood acute lymphoblastic leukemia, it was shown that HLA I expression and KIR receptor-ligand mismatch significantly impact ALL cytolysis.
Patrick Schlegel, Kerstin Ditthard, Peter Lang, Markus Mezger, Sebastian Michaelis, Rupert Handgretinger, Matthias Pfeiffer   +6 more
doaj   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

T cell derived cytokines IFN-gamma and TNF-alpha can reduce HBV cccDNA without cytolysis.

, 2015
Viral clearance involves immune cell cytolysis of infected cells. However, studies of HBV infection in chimpanzees (Guidotti et al. 1999) have indicated that cytokines released by immune cells can also achieve antiviral effects via non-cytolytic ...
Protzer, U., Wettengel, J.M., Stadler, D., Xia, Y., Lucifora, J., Chou, W.M., Heikenwälder, M., Malo, A., Reisinger, F., Wisskirchen, K.   +9 more
core  

Investigation of the Protective Effect of Morin on Oxidative Stress and Apoptosis in Malathion‐Induced Hepatotoxicity in Rats

Environmental Toxicology, EarlyView.
ABSTRACT Malathion (MAL) is a widely used organophosphate pesticide associated with hepatotoxicity through oxidative stress and apoptosis. Morin, a naturally occurring flavonoid, exhibits potent antioxidant and anti‐inflammatory properties. This study investigated oxidative stress, inflammatory, and apoptotic alterations induced by acute and subacute ...
Seval Yılmaz, Eda İ. Demirbağ, Hakan Bağ, Ali O. Çeribaşı   +3 more
wiley   +1 more source