Results 21 to 30 of about 44,623 (260)
A PD1-CD137L Fusion Protein More Potently Enhances Anti-Tumour Immune Responses Than Targeting PD-L1 and CD137 Separately. [PDF]
ImmunologyA PD1‐CD137L fusion protein converts the immunoinhibitory PD‐L1 to an immunostimulatory signal and is more effective than targeting PD‐L1 and CD137 separately. ABSTRACT Tumour immune evasion frequently involves PD‐L1‐mediated inhibition of T cell activity, limiting the efficacy of PD1/PD‐L1 blockade, particularly in PD‐L1‐low or immunologically ‘cold ...
Xia R +10 more
europepmc +2 more sources
Frontiers in Immunology, 2013 Functional responses of Natural Killer (NK) cells including eradication of ‘harmful’ cells and modulation of immune responses are regulated by a broad variety of activating and inhibitory NK receptors. Whereas the leukocyte receptor complex (LRC) encodes
Yvonne eBartel +2 more
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Сучасні медичні технології, 2022 . The search for new strategies for the correction of exogenous toxic liver lesions is due to the steady increase in the incidence of hepatitis and cirrhosis among the working population, which is an important medical and social problem. The aim is to
I. V. Koshurba
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Pathogens, 2023 Trichomonas vaginalis is responsible for 156 million new cases per year worldwide. When present asymptomatically, the parasite can lead to serious complications, such as development of cervical and prostate cancer.
Graziela Vargas Rigo +6 more
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Interferon as a macrophage activating factor. I. Enhancement of cytotoxicity by fresh and matured human monocytes in the absence of other soluble signals [PDF]
, 1983 The cytolytic activity ofhuman peripheral blood monocytes in vitro against K-562 human leukaemic target cells was stimulated by human fibroblast (fi-) and leucocyte (a-) interferon (IFN). Stimulation was by up to several times the corresponding control
Virelizier, JL, Dean, RT
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Eosinophil secretion of granule-derived cytokines
Frontiers in Immunology, 2014 Eosinophils are tissue-dwelling leukocytes, present in the thymus, and gastrointestinal and genitourinary tracts of healthy individuals at baseline, and recruited, often in large numbers, to allergic inflammatory foci and sites of active tissue repair ...
Lisa A Spencer +3 more
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Direct entry of cell-penetrating peptide can be controlled by maneuvering the membrane curvature
Scientific Reports, 2021 A biomembrane's role is to be a barrier for interior cytosol from an exterior environment to execute the cell's normal biological functions. However, a water-soluble peptide called cell-penetrating peptide (CPP) has been known for its ability to directly
Kazutami Sakamoto +9 more
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Mechanism of Cytolysis by Complement [PDF]
Proceedings of the National Academy of Sciences, 1972 The attack of complement is directed against the lipid moiety of the cell membrane; a single lesion at the site of fixation of complement proteins C5-C9 is responsible for lysis of a cell. There are two hypothetical models for the generation of this membrane lesion. The first of these, designated the leaky-patch
openaire +2 more sources
Journal of Lipid Research, 2007 Dietary supplementation with polyunsaturated fatty acids (PUFAs) has immunosuppressive effects; however, the molecular targets of PUFAs and their mode of action remain unclear.
Saame Raza Shaikh, Michael Edidin
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DOCK2 Mutation and Recurrent Hemophagocytic Lymphohistiocytosis
Life, 2023 Hemophagocytic lymphohistiocytosis (HLH) is a syndrome resulting from uncontrolled hyper-inflammation, excessive immune system activation, and elevated levels of inflammatory cytokines.
Daniel D. Reiff +2 more
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