Results 1 to 10 of about 63,717 (177)

Venom immunotherapy in indolent systemic mastocytosis with high serum tryptase level

Human Vaccines & Immunotherapeutics, 2021
Mastocytosis is a rare group of disorders characterized by abnormal accumulation of mast cells in the skin, bone marrow, and internal organs. In particular, patients with systemic mastocytosis are at an increased risk of frequent and severe episodes of ...
Ali Selcuk, Abdullah Baysan
doaj   +1 more source

Molecular quantification of tissue disease burden is a new biomarker and independent predictor of survival in mastocytosis

Haematologica, 2020
A high allele burden of the KIT D816V mutation in peripheral blood or bone marrow aspirates indicates multi-lineage hematopoietic involvement and has been associated with an aggressive clinical course of systemic mastocytosis.
Georg Greiner, Michael Gurbisz, Franz Ratzinger, Nadine Witzeneder, Svenja Verena Class, Gregor Eisenwort, Ingrid Simonitsch-Klupp, Harald Esterbauer, Matthias Mayerhofer, Leonhard Müllauer, Wolfgang R. Sperr, Peter Valent, Gregor Hoermann   +12 more
doaj   +1 more source

Comprehensive mastocytosis data analysis from a single center

BMC Cancer, 2023
Mastocytosis is a very rare disorder and is divided into three prognostically distinct variants by World Health Organization: Cutaneous mastocytosis (CM), systemic mastocytosis (SM), and mast cell sarcoma or localized mast cell (MC) tumors.
Tarık Onur Tiryaki, Sıdıka Gülkan Özkan, Simge Erdem, Aynur Dağlar Aday, İpek Yönal Hindilerden, Aslı Gelincik, Can Baykal, Gülçin Yegen, İbrahim Öner Doğan, Nesimi Büyükbabani, Meliha Nalçacı, Akif Selim Yavuz   +11 more
doaj   +1 more source

Systemic mastocytosis – a diagnostic challenge

Revista Brasileira de Hematologia e Hemoterapia, 2014
Mastocytosis refers to a group of disorders characterized by the infiltration of clonally derived mast cells to the skin or extracutaneous tissues resulting in a heterogeneous clinical picture. It is a rare hematologic disorder in all its forms. The exact incidence is unknown; it affects patients of any age and males and females equally.
Lladó, AC, Mihon, C, Silva, M, Galzerano, A   +3 more
openaire   +4 more sources

[Systemic mastocytosis].

Medicina cutanea ibero-latino-americana, 1989
213
Almagro Sanchez, M., Fonseca Capdevila, E., Sanchez Gil, A., Casado Jimenez, M., Jimenez Acosta, F.   +4 more
openaire   +4 more sources

Case Report: Treatment of systemic mastocytosis with sunitinib [version 1; referees: 2 approved]

F1000Research, 2017
Mast cell activation disease typically presents as chronic multisystem polymorbidity of generally inflammatory ± allergic theme.  Presently, treatment of the rare, cytoproliferative variant systemic mastocytosis employs empirically selected therapies to ...
Gerhard J. Molderings, Lawrence B. Afrin, Hans-Jörg Hertfelder, Stefan Brettner   +3 more
doaj   +1 more source

Systemic Mastocytosis Presenting as Acute Appendicitis: A Case Report and Review of the Literature

Case Reports in Oncology, 2013
Systemic mastocytosis is characterized by abnormal growth and accumulation of mast cells in various organs. Gastrointestinal (GI) symptoms are common disease manifestations in this disease and can significantly impair the quality of life.
Syed A. Akbar, Shahzad Raza, Jason E. Denney, Eric J. Johannesen, Donald C. Doll   +4 more
doaj   +1 more source

Multiple large osteolytic lesions in a patient with systemic mastocytosis: a challenging diagnosis

Clinical Case Reports, 2017
Key Clinical Message Patients with advanced variants of Systemic Mastocytosis may develop destructive bone lesions when massive mast cell (MC) infiltrates are present. Finding of large osteolyses in indolent systemic mastocytosis, typically characterized
Massimiliano Bonifacio, Roberta Zanotti, Emanuele Guardalben, Elda Mimiola, Francesca Scognamiglio, Omar Perbellini, Giovanna De Matteis, Luis Escribano, Patrizia Bonadonna, Daniela Grigolato, Sergio Bissoli, Alice Parisi, Alberto Zamò, Achille Ambrosetti, Maurizio Rossini   +14 more
doaj   +1 more source

Avapritinib treatment of aggressive systemic mastocytosis with a novel KIT exon 17 mutation

Leukemia Research Reports
Background: Systemic mastocytosis is a rare hematologic malignancy that leads to the accumulation of neoplastic mast cells in the bone marrow, visceral organs, and skin.
Lyndsey Sandow, Ajia Town, Michael C. Heinrich   +2 more
doaj   +1 more source

Clonal analysis of NRAS activating mutations in KIT-D816V systemic mastocytosis

Haematologica, 2011
Cooperating genetic events are likely to contribute to the phenotypic diversity of KIT-D816V systemic mastocytosis. In this study, 44 patients with KIT-D816V systemic mastocytosis were evaluated for coexisting NRAS, KRAS, HRAS or MRAS mutations ...
Todd M. Wilson, Irina Maric, Olga Simakova, Yun Bai, Eunice Ching Chan, Nicolas Olivares, Melody Carter, Dragan Maric, Jamie Robyn, Dean D. Metcalfe   +9 more
doaj   +1 more source