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Mast cell tryptase and asthma [PDF]
Mediators of Inflammation, 1997 Recent physiological and pharmacological studies have indicated the potential importance of tryptase, the major protein component in mast cells, in inflammatory diseases (especially asthma).
M-Q. Zhang, H. Timmerman
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Tryptase and tumor angiogenesis [PDF]
Frontiers in OncologyTryptases represent the most abundant constituent of human mast cells, involved in extracellular matrix degradation, contributing to wound healing and metastasis. Moreover, most recently, it has been demonstrated that tryptase is angiogenic both in vitro
Domenico Ribatti
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Nafamostat Mesilate Is an Extremely Potent Inhibitor of Human Tryptase
Journal of Pharmacological Sciences, 2003 Previously, nafamostat mesilate was found to be a potent inhibitor of human tryptase. In present study, we performed a kinetic study to determine its Ki value for tryptase and compared it with that of gabexate mesilate.
Shuji Mori +2 more
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Understanding Tryptase Physiology, Clinical Significance, and Diagnostic Applications: Where Do We Stand? [PDF]
BiomoleculesTryptase is the principal biomarker of mast cell (MC) burden and activation, routinely used in the diagnosis and management of MC-related disorders. Beyond its established role in confirming anaphylaxis, serum tryptase has gained increasing relevance in ...
Mara De Amici +7 more
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Tryptase genetics and anaphylaxis [PDF]
Journal of Allergy and Clinical Immunology, 2006 Tryptases secreted by tissue mast cells and basophils can enter the bloodstream. In human subjects tryptases are encoded by several genes and alleles, including alpha, beta, gamma, and delta. Common variations include complete absence of alpha genes.
George Caughey
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A simple, sensitive and safe method to determine the human α/β-tryptase genotype. [PDF]
PLoS ONE, 2014 The human tryptase locus on chromosome 16 contains one gene encoding only β-tryptase and another encoding either β-tryptase or the homologous α-tryptase, providing α:β gene ratios of 0:4, 1:3 or 2:2 in the diploid genome, these genotypes being of ...
Quang Trong Le +3 more
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Mast Cell Tryptase Potentiates Neutrophil Extracellular Trap Formation
Journal of Innate Immunity, 2021 Previous research has indicated an intimate functional communication between mast cells (MCs) and neutrophils during inflammatory conditions, but the nature of such communication is not fully understood.
Gunnar Pejler +6 more
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Circulating tryptase as a marker for subclinical atherosclerosis in obese subjects. [PDF]
PLoS ONE, 2014 INTRODUCTION: Mast cells participate in atherogenesis by releasing cytokines to induce vascular cell protease expression. Tryptase is expressed highly in human atherosclerotic lesions and the inhibition of tryptase activity hampers its capacity to ...
María Moreno +6 more
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Tryptase Regulates the Epigenetic Modification of Core Histones in Mast Cell Leukemia Cells
Frontiers in Immunology, 2021 Mast cells are immune cells that store large amounts of mast cell-restricted proteases in their secretory granules, including tryptase, chymase and carboxypeptidase A3.
Sultan Alanazi +2 more
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Clinical and Translational Science, 2023 Tryptase, a protease implicated in asthma pathology, is secreted from mast cells upon activation during an inflammatory allergic response. MTPS9579A is a novel monoclonal antibody that inhibits tryptase activity by irreversibly dissociating the active ...
Sharon M. Rymut +9 more
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