Results 31 to 40 of about 21,184 (241)

Genetic, morphological and functional characteristics of human tryptase

Аллергология и Иммунология в Педиатрии
Introduction. Tryptase, a mast cell-derived protease, plays a significant role in the diagnosis and pathogenesis of allergic and inflammatory diseases.
N. E. Tarasova, A. A. Lebedenko, O. E. Semernik, N. M. Dobaeva, V. O. Skosar, N. Yu. Haygetyan, I. P. Krivokhlyabov, S. P. Shkilnyuk   +7 more
doaj   +1 more source

Mast cells and tryptase. Modern aspects

Медицинская иммунология, 2021
The present review considers the role of mast cells (MC) and tryptase levels in various pathological conditions in children and adults. The main causes of hypertryptasemia are presented, as well as a list of the most important stimuli that can cause ...
D. Sh. Macharadze
doaj   +1 more source

Tryptase: genetic and functional considerations. [PDF]

, 2012
[EN] Tryptase is one of the main proteases located in the secretory granules of the mast cells, and is released through degranulation. It is therefore assumed to play an important role in inflammatory and allergic processes.
Lorente Toledano, Félix, Padrón, J, Isidoro García, María, Hernández Hernández, Laura, García Sánchez, María Asunción, Sanz Lozano, Catalina Sofía, García Solaesa, Virginia, Dávila González, Ignacio Jesús   +7 more
core   +1 more source

Effect of tryptase on mouse brain microvascular endothelial cells via protease-activated receptor 2

Journal of Neuroinflammation, 2018
Background Mast cells (MCs), the ‘first responders’ in brain injury, are able to disrupt the blood–brain barrier (BBB), but the underlying mechanism is not well understood. Tryptase is the most abundant MC secretory product. Protease-activated receptor 2
Qin Zhou, Yi-wei Wang, Peng-fei Ni, Yi-nan Chen, Hong-quan Dong, Yan-ning Qian   +5 more
doaj   +1 more source

Direct effects of mast cell proteases, tryptase and chymase, on bronchial epithelial integrity proteins and anti-viral responses

BMC Immunology, 2021
Background Mast cells (MCs) are known to contribute to both acute and chronic inflammation. Bronchial epithelial cells are the first line of defence against pathogens and a deficient anti-viral response has been suggested to play a role in the ...
Sangeetha Ramu, Hamid Akbarshahi, Sofia Mogren, Frida Berlin, Samuel Cerps, Mandy Menzel, Morten Hvidtfeldt, Celeste Porsbjerg, Lena Uller, Cecilia K. Andersson   +9 more
doaj   +1 more source

Supplementary Material for: A Novel, Nonpeptidic, Orally Active Bivalent Inhibitor of Human β-Tryptase

, 2018
β-Tryptase is released from mast cells upon degranulation in response to allergic and inflammatory stimuli. Human tryptase is a homotetrameric serine protease with 4 identical active sites directed toward a central pore.
Pingle M. (5673863), Arnold L.D. (5673869), Giardina S.F. (5673857), Werner D.S. (5673860), Bergstrom D.E. (5673866), Barany F. (5673872)   +5 more
core   +1 more source

Clinical effectiveness of hymenoptera venom immunotherapy [PDF]

, 2013
Treatment failure during venom immunotherapy (VIT) may be associated with a variety of risk factors. Our aim was to evaluate the association of baseline serum tryptase concentration (BTC) and of other parameters with the frequency of VIT failure during ...
Scheipl, Fabian, Darsow, Ulf, Reider, Norbert, Bonifazi, Floriano, Aberer, Werner, Schmid-Grendelmeier, Peter, Ruëff, Franziska, Treudler, Regina, Biló, Maria Beatrice, Sturm, Gunter Johannes, Küchenhoff, Helmut, Severino, Maurizio, Wüthrich, Brunello, Seitz, Michael J., Quercia, Oliviero, Bodzenta-Lukaszyk, Anna, Lang, Roland, Haeberli, Gabrielle, Campi, Paolo, Hawranek, Thomas, Müller, Ulrich, Przybilla, Bernhard   +21 more
core   +1 more source

Protective role of mouse mast cell tryptase Mcpt6 in melanoma [PDF]

, 2020
Tryptase-positive mast cells populate melanomas, but it is not known whether tryptase impacts on melanoma progression. Here we addressed this and show that melanoma growth is significantly higher in tryptase-deficient (Mcpt6(-/-)) versus wild-type mice ...
Melo, Fabio Rabelo, Hellman, Lars, Akula, Srinivas, Grujic, Mirjana, Pejler, Gunnar, Gustafson, Ann-Marie   +5 more
core   +1 more source

Influence of Perinatal Factors on Blood Tryptase and Fecal Calprotectin Levels in Newborns

Children, 2023
Background: Blood tryptase and fecal calprotectin levels may serve as biomarkers of necrotizing enterocolitis. However, their interpretation may be hindered by the little-known effects of perinatal factors.
Justine Paysal, Charlotte Oris, Ugo Troin, Pierre-Nicolas Limeri, Jeanne Allard, Marie Tadrent, Bruno Pereira, Etienne Merlin, Emmanuelle Rochette, Bertrand Evrard, Julie Durif, Vincent Sapin, Maguelonne Pons   +12 more
doaj   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source