Results 51 to 60 of about 21,184 (241)
Inducible Laryngeal Obstruction in Hypermobile Patients
The Laryngoscope, EarlyView.Patients with hypermobile Ehlers‐Danlos syndrome (hEDS) or hypermobility spectrum disorders (HSD) who screened positive for inducible laryngeal obstruction (ILO) reported significantly greater voice, cough, swallowing, gastrointestinal, and mast cell‐related symptoms than those without ILO. Chronic cough, dysphagia, and elevated mast cell symptom score
Stacey M. Menton +10 more
wiley +1 more source
Localization of rat tryptase to a subset of the connective tissue type of mast cell.
, 1993 We examined the cellular distribution of rat tryptase in rat skin, lung, small intestine, and peritoneal lavage cells by immunohistochemical techniques.
Z Chen +8 more
core +1 more source
Arthritis Research & Therapy, 2017 Background Increasing evidences indicate that an unbalance between tryptases and their endogenous inhibitors, leading to an increased proteolytic activity, is implicated in the pathophysiology of rheumatoid arthritis.
Alexandre Denadai-Souza +8 more
doaj +1 more source
Tryptase activation of immortalized human urothelial cell mitogen-activated protein kinase. [PDF]
PLoS ONE, 2013 The pathogenesis of interstitial cystitis/painful bladder syndrome (IC/PBS) is multifactorial, but likely involves urothelial cell dysfunction and mast cell accumulation in the bladder wall.
John O Marentette +5 more
doaj +1 more source
Asthma: From Phenotypes to Endotypes—Beyond Type 2 Inflammation
Respirology, EarlyView.ABSTRACT Asthma is a heterogeneous syndrome featuring variable pathophysiology, clinical presentation and treatment response. This review examines a comprehensive endotype‐phenotype framework for asthma assessment with an emphasis on characteristics beyond T2 inflammatory status alone.
Mario Fernando, Gregory G. King
wiley +1 more source
Safety of Venom Immunotherapy in Pregnancy: A Multicentre Study
Allergy, EarlyView.Venom immunotherapy (VIT) during pregnancy, when maintenance dose is well tolerated, can be continued. No increased risk of adverse effects to VIT or safety concerns for the pregnancy or the newborns were observed. No decreased efficacy of VIT, in case of re‐stings, was reported.
Matteo Martini +20 more
wiley +1 more source
Determinants of Poor Health‐Related Quality of Life in Patients With Food Allergy
Allergy, EarlyView.Machine‐learning analysis of 502 well‐characterised food‐allergic patients was used to identify key determinants of poor FA‐HRQL, defined as FAQLQ ≥ 5. The most relevant predictors were adult age, female sex, multiple food allergies, severe reactions, need for urgent care, onset before 18 years, and longer disease duration.
Rosialzira Natasha Vera‐Berrios +24 more
wiley +1 more source
Time‐Resolved Multi‐Omics Identify Biomarkers of Immediate Reactions to mRNA Vaccination
Allergy, EarlyView.We compared early vaccine‐induced immune and metabolic signatures and downstream immunity after second and booster BNT162b2 doses in participants with sARs, ISSRs, or no reactions. Neutrophil mobilization, antiviral programs, and robust anti‐S‐antibody responses occurred across reaction groups.
Ana Olivera +14 more
wiley +1 more source
Acta Biochimica PolonicaBackgroundDysregulated inflammation is central to COVID-19 pathogenesis. Mast cells (MCs) and their protease tryptase are implicated in tissue injury and vascular dysfunction, but the prognostic value of circulating tryptase in COVID-19 remains uncertain.
Alan Majeranowski +8 more
doaj +1 more source
Tryptase Is Not Cleared by the Kidneys into the Urine [PDF]
International Archives of Allergy and Immunology, 2009 <i>Background:</i> Patients with chronic kidney disease have been reported to have increased concentrations of blood tryptase. Detection of tryptase in the urine of healthy subjects has been reported. <i>Objective:</i> The objective is to determine whether tryptase is indeed cleared by the kidneys.
Michael R, Simon +6 more
openaire +2 more sources