Results 71 to 80 of about 21,184 (241)

Extending the role of tryptase in perioperative anaphylaxis: Predicting positive results in basophil activation tests

Journal of Allergy and Clinical Immunology: Global
Background: Basophil activation tests (BATs) are useful in identifying culprits of perioperative anaphylaxis (PA), but their utility remains limited due to technical limitations, cost, and availability.
Hugo W.F. Mak, MBBS, MRes[Med], Elaine Y.L. Au, FRCPA, Maegan H.Y. Yeung, MBBS, Valerie Chiang, MBBS, Ki Lam, FRCPA, Jane C.Y. Wong, FHKCP, Heather H.F. Yeung, MSc, Eric Y.T. Chan, FRCPath, Chak-sing Lau, MD, FRCP, Philip H. Li, MD, FRCP   +9 more
doaj   +1 more source

Mast cells and mast cell tryptase enhance migration of human lung fibroblasts through protease-activated receptor 2

Cell Communication and Signaling, 2018
Background Mast cells may activate fibroblasts and contribute to remodeling processes in the lung. However, the mechanism behind these actions needs to be further investigated. Fibroblasts are major regulators of on-going remodeling processes.
Mariam Bagher, Anna-Karin Larsson-Callerfelt, Oskar Rosmark, Oskar Hallgren, Leif Bjermer, Gunilla Westergren-Thorsson   +5 more
doaj   +1 more source

The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis

Allergy, EarlyView.
ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith, Nicholas P. West, Stanley Du Preez, Hugh A. Sampson, Peter W. Hellings, David Price, Liam O'Mahony, Carina Venter, Cezmi A. Akdis, Gil Yosipovitch   +9 more
wiley   +1 more source

Tryptase is not cleared by the kidneys into the urine

, 2010
Background: Patients with chronic kidney disease have been reported to have increased concentrations of blood tryptase. Detection of tryptase in the urine of healthy subjects has been reported. Objective: The objective is to determine whether tryptase is
Nori, Uday, Hu, Jiang, Akin, Cem, Schwartz, Lawrence B, Jan, Mindy, Simon, Michael R, Yee, Jerry   +6 more
core   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Effect of general anesthesia and orthopedic surgery on serum tryptase

, 2010
Mast cell tryptase is used clinically in the evaluation of anaphylaxis during anesthesia, because symptoms and signs of anaphylaxis are often masked by the effect of anesthesia.
Garvey, Lene H, Krøigaard, Mogens, Husum, Bent, Bech, Birgitte Louise, Mosbech, Holger, Belhage, Bo, Poulsen, Lars K, Birgitte Bech, Holger Mosbech, Lene H. Garvey, Bent Husum, Lars K. Poulsen, Bo Belhage, Mogens Krøigaard   +13 more
core   +1 more source

Expression of mast cell tryptase and immunoglobulin E is increased in cutaneous photodamage: implications for carcinogenesis

Journal of Dermatological Treatment
Purpose: Mast cells, their serine proteinase tryptase, and immunoglobulin E (IgE) can be involved in cutaneous carcinogenesis.Materials and methods: To study the association of tryptase+ and IgE+ cells with photodamage and skin cancers 385 adult patients
Jenni Korhonen, Hanna Siiskonen, Salla Haimakainen, Rauno J. Harvima, Ilkka T. Harvima   +4 more
doaj   +1 more source

The release of tryptase from mast cells promote tumor cell metastasis via exosomes

BMC Cancer, 2019
Background Cancer cells release exosomes and can be taken up by mast cells (MCs), but the potential functional effects of MCs on tumor metastasis remain unknown. Method Exosomes were isolated from the lung adenocarcinoma cell line A549, and the uptake of
Hui Xiao, Mudan He, Guogang Xie, Yanan Liu, Yuxia Zhao, Xiong Ye, Xingjing Li, Min Zhang   +7 more
doaj   +1 more source

Protein Corona‐Coated Crystal Silica From Sandstorms Amplifies Allergic Rhinitis by Regulating Epithelial Integrity in Mice and Human Nasal Epithelia

Allergy, EarlyView.
Cuishuang Dong, Xu Zhang, Haoyue Wang, Jiajing Cui, Shuai Han, Yibo Wang, Huanying Zhao, Yang Song, Yuan Zhang, Xiaobo Li   +9 more
wiley   +1 more source

Colonic Mast Cell Density and Diarrhoea: Evidence Against a Threshold Effect in Biopsies From 3508 Patients

Alimentary Pharmacology &Therapeutics, EarlyView.
A large data base of colonoscopies was analysed for mast cells. The data do not show a relationship between diarrhoea and elevated mast cells in the colonic mucosa. This study provides real‐world evidence against the routine diagnostic use of colonic mast cell quantification for the evaluation of diarrhoea.
Marlena Langreiter, Robert M. Genta, Philipp Schreiner   +2 more
wiley   +1 more source