Results 91 to 100 of about 21,184 (241)

Proteolytic Histone Modification by Mast Cell Tryptase, a Serglycin Proteoglycan-dependent Secretory Granule Protease

, 2014
Background: Tryptase is a serglycin proteoglycan-dependent protease localized in mast cell granules.  Results: Tryptase was found to degrade core histones, both during apoptosis and in viable cells.  Conclusion: A serglycin-tryptase axis is ...
Melo, Fabio rabelo,, Sveriges lantbruksuniversitet., Pejler, Gunnar,   +2 more
core   +1 more source

ICSH Guidance on Bone Marrow Examination and Reporting

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Examination of the bone marrow (BM) remains fundamental to the diagnosis, classification, prognostication, and monitoring of hematolymphoid and other disorders affecting blood cell production. Since publication of the International Council for Standardization in Haematology (ICSH) guideline in 2008, advances in diagnostic technologies, disease
Wendy N. Erber, Alexandar Tzankov, Olga Pozdnyakova, Hiromichi Matsushita, Gina Zini, Leonie Saft, on behalf of the International Council for Standardization in Haematology   +6 more
wiley   +1 more source

Pediatric anaphylaxis in the emergency department: Performances of dynamic tryptase measurement

Journal of Allergy and Clinical Immunology: Global
Background: Dynamic measurement of serum acute (sAT) and baseline (sBT) tryptase confirms mast cell degranulation during systemic hypersensitivity reactions, provided timing and interpretation are appropriate.
Constance Gonzalez, MD, Meng Sun, MSc, Aurélie Morand, MD, PhD, Philippe Minodier, MD, Marc Leone, MD, PhD, Jean-Christophe Dubus, MD, PhD, Joana Vitte, MD, PhD, Moïse Michel, PharmD, PhD   +7 more
doaj   +1 more source

Algorithms in Allergy: Diagnosis of Hypereosinophilic Syndromes, 2026 Update

Allergy, EarlyView.
Guillaume Lefèvre, Florence Roufosse, Giacomo Emmi, Andreas Reiter, Emmanuel Ledoult, Jean‐Emmanuel Kahn   +5 more
wiley   +1 more source

Management of chronic urticaria: Current status and future prospect

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Chronic urticaria is driven by mast cell activation through autoimmune, inflammatory, and neuroimmune pathways. A structured approach combining diagnosis, patient‐reported outcomes, stepwise therapy, treatment optimization, monitoring and emerging targeted agents may improve disease control and enable more personalized management.
Andaç Salman, Mona Al‐Ahmad, Maryam Al‐Nesf, Chia‐Yu Chu, Luis Felipe Ensina, Ana M. Gimenez‐Arnau, Margarida Gonçalo, Clive Grattan, Michihiro Hide, Pavel Kolkhir, Martin Metz, Iman Nasr, Romi Saini, Simon Francis Thomsen, Torsten Zuberbier, Emek Kocaturk   +15 more
wiley   +1 more source

The role of tryptase and anti-type II collagen antibodies in the pathogenesis of idiopathic epiretinal membranes

, 2015
Tsunehiko Ikeda,1 Kimitoshi Nakamura,2 Hidehiro Oku,1 Seita Morishita,1 Masanori Fukumoto,1 Hiroyuki Suzuki,1 Teruyo Kida,1 Taeko Horie,1 Tetsuya Sugiyama,3 Shinji Takai4 1Department of Ophthalmology, Osaka Medical College, Takatsuki City, Osaka, Japan;
Morishita S, Nakamura K, Fukumoto M, Sugiyama T, Horie T, Oku H, Takai S, Kida T, Ikeda T, Suzuki H   +9 more
core  

Pyrrole carboxamidine tryptase inhibitors from leptonychia pubescens

, 2005
The root and stem bark extracts of a Nigerian sample of Leptonychia pubescens Keay (Sterculiaceae) were found to inhibit the serine protease tryptase, a potential therapeutic target for the treatment of asthma and chronic obstructive pulmonary disease ...
Soejarto, D. Doel, Flotow, Horst, Yang, Lay Kien, Butler, Mark S., Buss, Antony D., Ng, Sok Peng, Yoganathan, K., Daramola, B. O.   +7 more
core   +1 more source

The osteoimmune cell atlas of peri‐implantitis: A narrative scoping review

Periodontology 2000, EarlyView.
Abstract Background/Aim Peri‐implantitis represents a complex osteoimmune disorder characterized by dysregulated cellular ecosystems that drive chronic inflammation and accelerated peri‐implant bone loss. Materials and Methods This article was designed as a narrative scoping review to map and integrate the available evidence from transcriptomics ...
Emilio A. Cafferata, Anton Sculean, Frank Schwarz   +2 more
wiley   +1 more source

Neovascularization and mast cells with tryptase activity increase simultaneously in human pterygium

, 2007
Mast cells (MC) have been implicated in both normal and pathological angiogenesis, such as that in chronic inflammatory diseases and tumors. This assumption is partially supported by the close structural association between MC and blood vessels and the ...
Piras F, CRIVELLATO, Enrico, RIBATTI, Domenico, MAXIA, CRISTINA, Longo V, Murtas D, Maxia C, PERRA, MARIA TERESA, Perra MT, PIRAS, FRANCA, Nico B, NICO, Beatrice, Sirigu P., CRIVELLATO E, Mangieri D, De Giorgis M, MURTAS, DANIELA, Ribatti D, Domenico Ribatti, Longo, Vito, Sirigu, Paola, Cristina Maxia, MANGIERI, DOMENICA, Perra, M. Teresa, Enrico Crivellato, Domenica Mangieri, M. Teresa Perra, Vito Longo, Franca Piras, Michela De Giorgis, Paola Sirigu, Beatrice Nico, Daniela Murtas, De Giorgis, Michela   +33 more
core   +1 more source

Tryptase: The Silent Witness of Past and Ongoing Systemic Events

Medicina
Introduction: Tryptase is an important biomarker widely used in the laboratory confirmation of severe hypersensitivity reactions, especially anaphylaxis.
Irena Oštrić Pavlović, Sara Radović, Danka Krtinić, Jelena Spirić, Nataša Kusić, Antonije Veličković, Vesna Tomić-Spirić   +6 more
doaj   +1 more source