Results 81 to 90 of about 15,211 (199)
New Insights Into Immunomodulatory Strategies for Drug Hypersensitivity Reactions: An EAACI Task Force Report
Clinical and Translational Allergy, Volume 16, Issue 8, August 2026.ABSTRACT
Drug hypersensitivity reactions (DHRs) are a global health concern and remain challenging to investigate owing to the heterogeneity of endotypes and phenotypes, as well as the lack of standardized biomarkers. Until recently, strict drug avoidance was the only management strategy for severe DHRs.Ana Maria Copaescu, Valentina Gueli, Jitesh Chahuan, Waad Albalawi, Giovanna Sfriso, Mattia Giovannini, Leticia de las Vecillas, Aspasia Karavelia, Marina Labella, Ruben Fernandez‐Santamaria, Francesca Mori, Lene H. Garvey, Patrizia Bonadonna, Maria Jose Torres +13 morewiley +1 more sourceDivergent Atrial Transcriptomic Signatures in Diabetic and Nondiabetic Atrial Fibrillation
Journal of Arrhythmia, Volume 42, Issue 4, August 2026.Diabetes alters the atrial transcriptome in atrial fibrillation, characterized by enhanced mitochondrial ATP synthesis, suppressed immune and inflammatory pathways, and distinct miRNA expression profiles, suggesting metabolic and epigenetic remodeling of the atrial substrate.Kenshi Yoshimura, Yuya Kiriake, Hiroki Osanai, Mengyan Wei, Shinichiro Kume, Tatsuki Kurokawa, Masaki Morishima, Ryusuke Suzuki, Shinji Miyamoto, Katsushige Ono +9 morewiley +1 more sourceRCSB protein data Bank: Next‐generation advanced search for exploration of experimental structures and computed structure models
Protein Science, Volume 35, Issue 8, August 2026.Abstract
The Protein Data Bank (PDB), established in 1971, is the primary global, open‐access archive for experimentally determined 3D macromolecular structures (proteins, RNA, DNA). The research‐focused RCSB.org web‐portal provides access to these data alongside more than one million machine‐learning‐predicted structure models, greatly expanding the ...Yana Rose, Ronald Brown, Maria Voigt, Charmi Bhikadiya, Sebastian Bittrich, Jose M. Duarte, Joan Segura, Rachel Kramer Green, Stephen K. Burley +8 morewiley +1 more sourceIntegrating Surface Plasmon Resonance and Docking Analysis for Mechanistic Insights of Tryptase Inhibitors
MoleculesTryptase is a tetrameric serine protease and a key component of mast cell granules. Here, we explored an integrated approach to characterize tryptase ligands, combining novel experimental binding studies using Surface Plasmon Resonance, with in silico ...Alessia Porta, Candida Manelfi, Carmine Talarico, Andrea Rosario Beccari, Margherita Brindisi, Vincenzo Summa, Daniela Iaconis, Marco Gobbi, Marten Beeg +8 moredoaj +1 more sourceSequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food
Allergy, Volume 81, Issue 8, Page 2726-2743, August 2026.ABSTRACT
Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.N. A. Nagy, D. Schnoegl, V. Houghton, L. O'Mahony, A. F. Santos, E. F. Knol, A. Kuehn, T. Eiwegger +7 morewiley +1 more sourceThe International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria
Allergy, Volume 81, Issue 8, Page 2582-2632, August 2026.ABSTRACT
This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA2LEN) and its Urticaria and ...Torsten Zuberbier, Zainab AbdulHameed Ansari, Amir H. Abdul Latiff, M. M. Abuzakouk, Maria Socorro Agcaoili‐De Jesus, Rosana C. Agondi, Mona Al‐Ahmad, Abdullah A. Alangari, H. Alhameli, Cesar D. Alonso Bello, Saad Alshareef, Salem Al‐Tamemi, Sabine Altrichter, Humaid Al Wahshi, S. Aquilina, M. Araújo, Rand Arnaout, Riccardo Asero, Barbara Ballmer‐Weber, Christine Bangert, Andrea Bauer, Moshe Ben‐Shoshan, Jonathan A. Bernstein, Carsten Bindslev‐Jensen, Mojca Bizjak, Isabelle Boccon‐Gibod, Hanna Bonnekoh, Laurence Bouillet, Knut Brockow, Zenon Brzoza, M. Bulatović Ćalasan, Adeeb Bulkhi, Thomas Buttgereit, Anette Bygum, Teresa Caballero, Oscar Calderon, R. Campos, Mauro Cancian, Emily Carne, Mary Anne Castor, Inmaculada Cerecedo, T. Çetinarslan, Ivan Cherrez‐Ojeda, N. Chkhikvadze, Herberto J. Chong‐Neto, Karen Choo, George Christoff, Chia‐Yu Chu, K. Ciupka, Niall Conlon, Célia Costa, Timothy J Craig, Paulo Criado, Inna Danilycheva, Razvigor Darlenski, Erika De Arruda Chaves, Laurence de Montjoye, M.‐S. Doutre, Aurelie Du‐Thanh, Didier Ebo, S. Elkhalifa, S. Elmariah, Tariq El‐Shanawany, Luis F. Ensina, Ragip Ertaş, Roberta Fachini Jardim Criado, Marta Ferrer, Silvia Ferrucci, Jie Shen Fok, Daria Fomina, Luz Fonacier, Ghada Fouda, I. Francescantonio, Atsushi Fukunaga, César A. Galvan Calle, Elizabeth Garcia, Krisztian Gáspár, Aslı Gelincik, Songmei Geng, Kiran Godse, Margarida Gonçalo, Maia Gotua, C. Grattan, Martine Grosber, Guillermo Guidos Fogelbach, Mar Guilarte, R. Guillod, Eckard Hamelmann, Jason Hawkes, Koremasa Hayama, Ruben Heuer, Michihiro Hide, Wolfram Hoetzenecker, Naoko Inomata, Hye‐Ryun Kang, Allen P. Kaplan, Alexander Kapp, M. Karam, Alicja Kasperska‐Zajac, Constance H. Katelaris, Aharon Kessel, Maryam Khoshkhui, Brian Kim, Tamar Kinaciyan, Emek Kocatürk, Marta Kolacinska‐Flont, Pavel Kolkhir, George N. Konstantinou, Mitja Kosnik, Dorota Krasowska, Kanokvalai Kulthanan, Muthu S. Kumaran, Izabela Kuprys‐Lipinska, Moisés Labrador, Jose Ignacio Larco, Désirée Larenas‐Linnemann, Elena Latysheva, E. Lazaridou, Philip H. Li, H. Lima, Undine Lippert, Markus Magerl, Michael Makris, João Alves Marcelino, Angelo V. Marzano, Iris Medina, Raisa Meshkova, D. Micallef, Ramzy Mohammed Ali, Charlotte G. Mortz, Melba Munoz, Hanneke N. G. Oude Elberink, Alla Nakonechna, Iman Nasr, Alexander Nast, Elena Netchiporouk, Eustachio Nettis, Sandra Nieto, Isabel Ogueta Canales, T.‐L. Okas, Raquel L. Orfali, Esen Özkaya, Claudio Parisi, A. Pennitz, Ruby Pawankar, Manuel P. Pereira, Jonny Peter, Elena Petkova, P. D. Pigatto, Indrashis Podder, T. Popov, Grzegorz Porebski, Polina Pyatilova, German D. Ramon, Hector A. Ratti Sisa, Marysia Stella Recto, Krista Ress, Katie Ridge, Marc Riedl, Carla Ritchie, Nelson Rosario Filho, Isabel Rosmaninho, Michael Rudenko, Maia Rukhadze, Krzysztof Rutkowski, Vito Sabato, Umit M. Sahiner, Sarbjit Saini, F. Saleh Al Sabbagh, Andac Salman, Fulvio Salvo, Jorge Sanchez, A. Santucci, Sibylle Schliemann, Peter Schmid‐Grendelmeier, Bulent E. Sekerel, Faradiba Serpa, Farrukh Sheikh, J. Sheikh, H. Shendi, Frank Siebenhaar, M. Sonomjamts, Angele Soria, Bernardo Sousa Pinto, Maria Staevska, Petra Staubach, M. Stephan, Katarina Stevanovic, Luca Stingeni, Marcin Stobiecki, Özlem Su Küçük, Gordon Sussman, Andrea Szegedi, Shunsuke Takahagi, Akio Tanaka, Natasa Teovska Mitrevska, Simon Francis Thomsen, Elias Toubi, Fragkiski Tsatsou, Murat Turk, Zahava Vadasz, Anna Valerieva, Solange Valle, Martijn van Doorn, Beatriz Veleiro Perez, Carolina E. Vera Ayala, Christian Vestergaard, Rafael J. Vieira, C. W. Maruta, Bettina Wedi, Ricardo N. Werner, Evelyn Wen Yee Yap, Paraskevi Xepapadaki, Yi‐Kui Xiang, Young‐Min Ye, Patrick Yong, Gil Yosipovitch, Anna Zalewska‐Janowska, Christoph Zeyen, Zuotao Zhao, Martin Metz, Ana M. Giménez‐Arnau +221 morewiley +1 more sourceUtility of tryptase genotyping in the screening, diagnosis, and management of systemic mastocytosis
Frontiers in AllergyTryptase genotyping has an expanding role in the screening, diagnosis, and management of patients with systemic mastocytosis (SM). Reference ranges for basal serum tryptase (BST) based on increased TPSAB1 gene copy number can guide whether a patient's ...Jeremy C. McMurray, Jeremy C. McMurray, Brandon J. Schornack, Brandon J. Schornack, Joaquin Villar, Joaquin Villar, Tracy I. George, Nathan A. Boggs, Nathan A. Boggs +8 moredoaj +1 more source
