Results 101 to 110 of about 21,184 (241)

Downregulation of iNOS, IL-1β, and P2X7 Expression in Mast Cells via Activation of PAR4 Contributes to the Inhibition of Visceral Hyperalgesia in Rats

Journal of Immunology Research, 2018
Protease-activated receptor 4 (PAR4) is implicated in the inhibition of visceral hyperalgesia. In the present study, the effects of PAR4 activation on visceral hypersensitivity and expression of inflammatory mediators, including interleukin-1β (IL-1β ...
Yanli Hao, Hao Niu, Shuhong An, Ming Wang, Zhaojin Wang   +4 more
doaj   +1 more source

A Rare Case Report of Type II Kounis Syndrome With Literature Review: Acute Anterior ST Elevation Myocardial Infarction Following Bee Sting

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Kounis syndrome (KS), also known as allergic angina, is a rare but serious condition defined by acute coronary syndrome occurring alongside a hypersensitivity reaction. We report the case of a 42‐year‐old male smoker who developed Type II KS after a hymenoptera sting.
Sara Tarkiani, Mobina Ghajar, Mohammad Hossein Sharifi Fard, Mohammad Ghasemi Palangi, Armin Bordbar, Hassan Ahangar, Amin Ramezani   +6 more
wiley   +1 more source

Very Long‐Term Stability of Tryptase in Frozen Serum Samples

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 276-277, March 2025.
Florent Broussal, Thomas Rouzioux, Dounia Khelifi‐Touhami, Sibylle Bachelier, Brigitte Berthier, Aicha Abbas, Simone Choi, Yannick Chantran   +7 more
wiley   +1 more source

Salicylic Acid as a Food‐Derived Bioactive Constituent of Tiaoqi Daozhi Decoction: A Potential Functional Food Ingredient to Restoring Gut Barrier Function in Constipation‐Predominant IBS

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Tiaoqi Daozhi Decoction (TQDZD) is a classic formulation composed of eight medicine‐food homologous botanicals. UPLC‐MS/MS profiling identified 1962 non‐redundant compounds in its aqueous extract, predominantly phenolic acids and flavonoids, of which 107 metabolites were systemically bioavailable.
Min Duan, Lixia Huang, Yingyue Xu, Ya Huang, Xiaojun Yang   +4 more
wiley   +1 more source

Human Mast Cell Tryptase Fibrinogenolysis: Kinetics, Anticoagulation Mechanism, and Cell Adhesion Disruption

, 1998
Tryptase is a 31 kDa, glycosylated, trypsin-like enzyme stored in and released from mast cell granules. Human tryptase exists as a tetramer, binds heparin, and has a limited substrate specificity, yet it displays remarkable resistance to inhibition by ...
Wheeless, Christine J., Thomas, Vanessa A., Stack, M. Sharon, Johnson, David A., David A. Johnson, Christine J. Wheeless, M. Sharon Stack, Vanessa A. Thomas   +7 more
core   +1 more source

Evaluating the Impact of Prior Sponge and Lavage Sampling on Gene Expression of Nasal CMA1 and TSLP Collected With Brush

Clinical &Experimental Allergy, EarlyView.
Abigail Davis, Sophie Spicer, Lubnaa Hossenbaccus, Anne K. Ellis   +3 more
wiley   +1 more source

Tumor‐Associated Mast Cells Drive Immunosuppression and Resistance to Anti‐PD‐1 Therapy in Hepatocellular Carcinoma Through CCL17/CCR4‐mediated Regulatory T‐Cell Recruitment

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
Our graphical abstract summarizes a novel immunosuppressive axis in HCC whereby tumor cell‐derived SCF recruits and activates mast cells, leading to CCL17 secretion and subsequent recruitment of CCR4+ regulatory T cells. This cascade suppresses CD8+ T cell‐mediated antitumor immunity and promotes resistance to anti‐PD‐1 therapy.
Shuai Yang, Chuang Yang
wiley   +1 more source

Diabetic Polyneuropathy Patients Exhibit an Altered Skeletal Muscle Proteome Phenotype

PROTEOMICS – Clinical Applications, Volume 20, Issue 6, November 2026.
ABSTRACT Purpose Diabetic polyneuropathy (DPN) is a debilitating complication of diabetes that affects motor nerves and may impair skeletal muscle health. This study investigated skeletal muscle proteomic alterations associated with DPN compared with type 2 diabetes without DPN (T2D) and healthy controls (CON).
Frederik Forsberg Thybo, Karolina Snopek Khan, Jesper Emil Jakobsgaard, Henning Andersen, Kristian Vissing, Johan Palmfeldt   +5 more
wiley   +1 more source

Tryptase genotyping in healthy subjects.

, 2014
α/β-Tryptase genotyping was performed with gDNA obtained from SMCs of 24 subjects. EcoRV digestions of PCR amplimers labeled during the final cycle with DY682-labeled 3′-primer were performed. Gel images are shown for 3 of the 24 samples analyzed, 2 with
Lawrence B. Schwartz (697842), Hae-Ki Min (605820), Sahar Lotfi-Emran (697841), Quang Trong Le (697840)   +3 more
core   +1 more source

Mast cell tryptase-PAR2 axis promotes ovarian fibrosis through RNF152-mediated stabilization of Bcl-xL.

Journal of Ovarian Research
Background Our research aimed to study the effect and mechanism of tryptase on ovarian fibrosis. Methods The POI mouse model was established by cisplatin at a dose of 1.5 mg/kg for ten days, while the control mice were given the same volume of saline ...
Xiang Zhang, Jun Zhang, Chaojun Wang
doaj   +1 more source