Results 111 to 120 of about 21,184 (241)

Casein as rare elicitor of food allergy dependent on augmentation factors ‐ A case report

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Charlotte Jasmin Kiani, Valentina Faihs, Julia Felicitas Pilz, Claudia Kugler, Tilo Biedermann, Knut Brockow   +5 more
wiley   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, Volume 36, Issue 86, 26 October 2026.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

Integrating Surface Plasmon Resonance and Docking Analysis for Mechanistic Insights of Tryptase Inhibitors

Molecules
Tryptase is a tetrameric serine protease and a key component of mast cell granules. Here, we explored an integrated approach to characterize tryptase ligands, combining novel experimental binding studies using Surface Plasmon Resonance, with in silico ...
Alessia Porta, Candida Manelfi, Carmine Talarico, Andrea Rosario Beccari, Margherita Brindisi, Vincenzo Summa, Daniela Iaconis, Marco Gobbi, Marten Beeg   +8 more
doaj   +1 more source

Human lung mast cell tryptase fails to activate procollagenase or degrade proteoglycan

, 1985
Pig synovial and human skin fibroblast procollagenases were treated with highly purified tryptase, the major proteinase of human mast cells, to determine whether this trypsin-like proteinase could activate the latent form of collagenase and so be ...
David A. Johnson, Timothy E. Cawston, Cawston, Timothy E., Johnson, David A.   +3 more
core   +1 more source

Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

International Forum of Allergy &Rhinology, Volume 16, Issue 10, Page 1094-1106, October 2026.
ABSTRACT Background Chronic rhinosinusitis with nasal polyp (CRSwNP) is a heterogeneous Type 2 inflammatory disease characterized by enhanced eosinophilic infiltration. Both innate and adaptive immunity are involved in the onset and progression of CRSwNP.
Yuki Sonoda, Yohei Sato, Yoshimasa Imoto, Mayumi Tamari, Shigeharu Fujieda   +4 more
wiley   +1 more source

Utility of tryptase genotyping in the screening, diagnosis, and management of systemic mastocytosis

Frontiers in Allergy
Tryptase genotyping has an expanding role in the screening, diagnosis, and management of patients with systemic mastocytosis (SM). Reference ranges for basal serum tryptase (BST) based on increased TPSAB1 gene copy number can guide whether a patient's ...
Jeremy C. McMurray, Jeremy C. McMurray, Brandon J. Schornack, Brandon J. Schornack, Joaquin Villar, Joaquin Villar, Tracy I. George, Nathan A. Boggs, Nathan A. Boggs   +8 more
doaj   +1 more source

Safety and Feasibility of Magnetic Separation‐Based Blood Purification

Advanced NanoBiomed Research, Volume 6, Issue 10, October 2026.
We present the preclinical biological safety and translational feasibility of a magnetic nanoparticle‐based extracorporeal blood purification platform for removal of disease‐causing blood factors. ISO 10993‐compliant studies and exaggerated worst‐case exposure models demonstrate efficient nanoparticle extraction (≥99.9%), favorable biocompatibility ...
Carlos A. Mora, Laurine Rijsbergen, Jan Waskowski, Gaelle Clermont, Florian Dingreville, Chandrashekara Vishwanath, Rajesh Karunanithi, Alexander Gogos, Jean‐Claude Metzger, Manuel Baumgartner, Joerg C. Schefold, Inge K. Herrmann   +11 more
wiley   +1 more source

Tryptase-stained skin biopsy.

, 2013
Skin biopsy in CUrt patient stained for tryptase (red) at baseline at low (10×, upper panels) and high (60×, lower panels) magnification and at 15 minutes following cold stimulation time test (CSTT-see methods).
Alexander M. Gorbach (381581), Nevenka Medic (381582), Hirsh D. Komarow (381587), Avanti Desai (381585), Dean D. Metcalfe (381586), Wei-Min Liu (1527772), Celeste Nelson (381583), Sarah Arceo (381584), Joseph Meyer (381580), Michael Young (40123)   +9 more
core   +1 more source

Immune cells in the pathogenesis of abdominal aortic aneurysm: Roles, regulation and targeted interventions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review provides a comprehensive overview of how macrophages, neutrophils, T cells and other immune cells infiltrate the aortic wall, undergo phenotypic shifts and interact with one another in abdominal aortic aneurysm (AAA). Background Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease with no approved clinical drugs. Immune
Junqi Peng, Hanqing Zhang, Yun Wu, Song Chen   +3 more
wiley   +1 more source

The role of human mast cell tryptase in allergic inflammation

, 1996
Mast cell tryptase, a tetrameric serine proteinase, is the major secretory product of human mast cells. We have investigated the potential contribution of this enzyme in allergic inflammation employing in vivo and in vitro models with laboratory animals ...
He, Shaoheng
core