Results 121 to 130 of about 21,184 (241)

Plasma PlGF as a Potential Biomarker in Ramucirumab‐Based Second‐Line Therapy for Advanced Gastroesophageal Adenocarcinoma: Exploratory Biomarker Analysis from the Phase II Part of the RAMIRIS Trial

International Journal of Cancer, Volume 159, Issue 7, Page 1817-1828, 1 October 2026.
Antiangiogenic treatment with ramucirumab is a standard second‐line option in advanced gastric and gastroesophageal junction adenocarcinoma. However, reliable biomarkers are currently lacking. This exploratory biomarker analysis of the RAMIRIS trial suggests that elevated baseline and early on‐treatment levels of the pro‐angiogenic placental growth ...
Jurek Hille, Sylvie Lorenzen, Claudia Pauligk, Victoria Gensch, Peter Thuss‐Patience, Eray Goekkurt, Thomas Ettrich, Florian Lordick, Carsten Bokemeyer, Christian Müller, Peter Reichardt, Martin Sökler, Daniel Pink, Stefan Probst, Thorsten O. Goetze, Salah E. Al‐Batran, Sonja Loges, Melanie Janning   +17 more
wiley   +1 more source

Case Report: A family history of peanut allergy and hereditary alpha-tryptasemia

Frontiers in Allergy
ContextHereditary alpha-tryptasemia (HαT) is associated with elevated basal serum tryptase (bST) and is associated with a higher risk of severe anaphylactic reactions in patients with clonal mast cell disorders or IgE-mediated Hymenoptera venom-induced ...
Yannick Chantran, Yannick Chantran, Yannick Chantran, Hélène Renaudin, Michel Arock, Michel Arock, Tamazoust Guiddir, Ariane Nemni   +7 more
doaj   +1 more source

Mast Cells in Host Defense Against Cutaneous Staphylococcus aureus Infection

Immunology &Cell Biology, Volume 104, Issue 9, Page 867-880, October 2026.
Impact of S. aureus epicutaneous sensitization models on mast cell function in vivo. D. farinae and Staphylococcal enterotoxin B (SEB) activate Trpv1+ Tac1+ nociceptors to trigger the release of substance P (SP), which promotes mast cell degranulation through Mrgprb2. S.
Hannah Dychtenberg, Carly Kadonoff, Bailey Lehnert, Priyanka Pundir   +3 more
wiley   +1 more source

Target-Directed Self-Assembly of Homodimeric Drugs Against β‑Tryptase

, 2018
Tryptase, a serine protease released from mast cells, is implicated in many allergic and inflammatory disorders. Human tryptase is a donut-shaped tetramer with the active sites facing inward forming a central pore.
Sarah F. Giardina (5540018), Douglas S. Werner (724232), Kenneth W. Foreman (213991), Francis Barany (22764), Donald E. Bergstrom (724238), Maneesh Pingle (724237), Lee D. Arnold (724236)   +6 more
core   +1 more source

Hereditary alpha tryptasemia and food allergy

Frontiers in Allergy
Food allergy (FA) and hereditary alpha-tryptasemia (HαT) are both relatively common conditions, but potential associations between these diagnoses have not been well-studied.
Abigail Lang
doaj   +1 more source

Application of Panax notoginseng Saponins in Skin Wound Repair: Mechanisms and Research Progress

Journal of Cellular and Molecular Medicine, Volume 30, Issue 20, October 2026.
ABSTRACT Skin wound repair involves four stages: haemostasis, inflammation, proliferation and remodelling. Refractory wounds feature prolonged healing cycles, severe scar hyperplasia and limited clinical therapeutic strategies. Panax notoginseng saponins (PNS), primarily the ginsenosides Rg1 and Rb1 monomers, display high safety and multitarget ...
Zhifeng Wang, Ting Shi, Daman Tian, Rui Li, Ting Yao, Junfeng Lan, Yujiang Xi, RuiRui Wang, Jian Wang   +8 more
wiley   +1 more source

Optimising Asparaginase Use and Managing Hypersensitivity in Australasia—A Clinical Practice Guideline From the Australian and New Zealand Children's Haematology/Oncology Group

Journal of Paediatrics and Child Health, Volume 62, Issue 10, Page 1913-1920, October 2026.
ABSTRACT Background Asparaginase is a critical component of modern multi‐agent chemotherapy regimens for paediatric acute lymphoblastic leukaemia and lymphoblastic lymphoma, with inadequate exposure leading to inferior patient outcomes. Objectives To develop a clinical practice guideline for the use of asparaginase products in the Australasian context.
Matthew J. O'Connor, Michelle Martin, Sarah M. Trinder, Draga Barbaric, Diane Hanna, Chow Y. Lai, Michael P. Osborn, Tim Prestige, Bryony Ross, Leanne Super, Thomas Walwyn, Stacie S. Wang, Andrew Wood, Andrew S. Moore, Rishi S. Kotecha, Siobhan Cross   +15 more
wiley   +1 more source

Complete inhibition of β-tryptase by tetramer dissociation and active site allostery due to a single antibody residue

Nature Communications
Human β-tryptase, a tetrameric trypsin-like serine protease, is an important mediator of inflammatory responses in asthma, allergy and other diseases. Here we report an anti-β-tryptase antibody with a superior mechanism of action compared to others since
Henry R. Maun, Caleigh M. Azumaya, Benjamin T. Walters, Rajesh Vij, Ashley Morando, Kelly M. Loyet, James T. Koerber, Alexis Rohou, Robert A. Lazarus   +8 more
doaj   +1 more source

Tryptase [PDF]

, 2020
openaire   +1 more source

A Multicenter, Open‐Label, Phase 2 Trial Comparing Crizanlizumab Combined With Standard Therapy to Standard Therapy Alone on Renal Function in Patients With Sickle Cell Nephropathy (STEADFAST)

American Journal of Hematology, Volume 101, Issue 10, Page 2666-2671, October 2026.
Kenneth I. Ataga, Pablo Bartolucci, Santosh L. Saraf, Vimal K. Derebail, Adlette Inati, Jeffrey D. Lebensburger, Laurie DeBonnett, Rodolfo D. Cancado, Claire C. Sharpe   +8 more
wiley   +1 more source