Results 11 to 20 of about 21,184 (241)

Tryptase promotes atherosclerotic plaque haemorrhage in ApoE-/- mice. [PDF]

PLoS ONE, 2013
Tryptase, the most abundant mast cell (MC) granule protein, plays an important role in atherosclerosis plaque development. To test the hypothesis that tryptase participates directly in atherosclerosis plaque haemorrhage, the gene sequence and siRNA for ...
Xiuling Zhi, Chen Xu, Hao Zhang, Dai Tian, Xiaobo Li, Yanxia Ning, Lianhua Yin   +6 more
doaj   +2 more sources

Isolation of Allosteric Tryptase Inhibitor from Methanol Extract of Rhubarb and Enhancement of Its Tryptase Inhibitory Activity by Compounds That Were Screened by In Silico Screening

Molecules
Tryptase, which is abundant in human mast cells and is involved in allergic inflammations such as asthma, is a serine protease. We isolated a tryptase inhibitor, procyanidin B8 3,3′-di-O-gallate (PB8GG’), a tannin, from the methanol extract of rhubarb ...
Hidetoshi Fujii, Moeno Ito, Kentaro Nishioka, Katsutoshi Nishino, Takanao Otsuka, Kazuhiro Irie, Takashi Tanaka, Masaya Nagao   +7 more
doaj   +2 more sources

Effects of Secreted Mast Cell Mediators on Retinal Pigment Epithelial Cells: Focus on Mast Cell Tryptase [PDF]

Mediators of Inflammation, 2017
Numerous mast cells are present in the choroid, but the effects of mast cell mediators on retinal pigment epithelial (RPE) cells are not well understood.
Rei Arai, Ayumi Usui-Ouchi, Yosuke Ito, Keitaro Mashimo, Akira Murakami, Nobuyuki Ebihara   +5 more
doaj   +2 more sources

Acute Profound Hypotension Following Intraoperative Plasma Transfusion-A Case Series. [PDF]

Acta Anaesthesiol Scand
ABSTRACT Background Blood transfusions can be lifesaving but carry risks of serious adverse reactions, including the less recognized hypotensive transfusion reaction, characterized by hypotension that may be difficult to distinguish from other transfusion reactions or haemorrhage‐related shock.
Batz T, Nordström J, Hertzberg D, Brismar V, Kåhlin J, Hedberg M, Von Oelreich E, Jonsson Fagerlund M.   +7 more
europepmc   +2 more sources

Mast Cell-Microglia Crosstalk Drives Aberrant Synaptic Pruning Through PAR-2/MAPK/NF-κB Signaling in Neonatal Hypoxic-Ischemic Encephalopathy. [PDF]

CNS Neurosci Ther
Following neonatal hypoxic–ischemic injury, hippocampal mast cell degranulation releases tryptase, which activates microglial PAR‐2 receptors to trigger p38 MAPK/NF‐κB signaling and drive aberrant synaptic engulfment. This pathological mast cell–microglia crosstalk leads to progressive synaptic loss and long‐term cognitive impairment.
Yang Y, Cai D, Yu J, Zhu Y, Huang Y, Lin Y, Teng C, Wei J, Lin Y, Dai D, Xue F, Chen A, Zheng X, Chen X.   +13 more
europepmc   +2 more sources

Tryptase activates enteric glial cells followed by affecting neuronal properties possibly via the stimuli-associated mediators

Journal of Pharmacological Sciences, 2023
Objectives: Mast cell-derived tryptase causes neuronal elongation/sensitization leading to visceral hypersensitivity. However, effects of tryptase on enteric glial cells (EGCs) and subsequent interaction between EGCs and neurons remain unknown.
Kazunari Tominaga, Yoshiko Fujikawa
doaj   +1 more source

Altered immunohistochemical expression of mast cell tryptase and chymase in the pathogenesis of oral submucous fibrosis and malignant transformation of the overlying epithelium. [PDF]

PLoS ONE, 2014
Mast cells (MCs) expressing serine proteases; tryptase and chymase, are associated with fibrosis in various diseases. However, little is known about their involvement in oral submucous fibrosis (OSF).
Archana Yadav, Rajiv S Desai, Bansari A Bhuta, Jatinder S Singh, Reema Mehta, Akash P Nehete   +5 more
doaj   +1 more source

Kinetic and thermodynamic analysis of leech-derived tryptase inhibitor interaction with bovine tryptase and bovine trypsin [PDF]

, 2000
The interaction of leech-derived tryptase inhibitor (LDTI) with bovine liver capsule tryptase (BLCT) and bovine trypsin has been studied using both thermodynamic and kinetic approaches.
Fiorucci, L., Ascoli F., COLETTA, MASSIMILIANO, Ascoli, F., FIORUCCI, LAURA, Erba, F., Sommerhoff, C. P., Coletta, M., Sommerhoff C. P., Erba F., Fiorucci L., Sommerhoff C.P., Coletta M., Ascoli F., ERBA, FULVIO   +10 more
core   +1 more source

Correlation between serum tryptase, mast cells positive to tryptase and microvascular density in colo-rectal cancer patients: possible biological-clinical significance. [PDF]

PLoS ONE, 2014
BACKGROUND: Tryptase is a serin protease stored and released from mast cells (MCs) that plays a role in tumour angiogenesis. In this study we aimed to evaluate serum tryptase levels in colo-rectal cancer (CRC) patients before (STLBS) and after (STLAS ...
Michele Ammendola, Rosario Sacco, Giuseppe Sammarco, Giuseppe Donato, Severino Montemurro, Eustachio Ruggieri, Rosa Patruno, Ilaria Marech, Marica Cariello, Angelo Vacca, Cosmo Damiano Gadaleta, Girolamo Ranieri   +11 more
doaj   +1 more source

Mast Cell β-Tryptase Is Enzymatically Stabilized by DNA

, 2020
Tryptase is a tetrameric serine protease located within the secretory granules of mast cells. In the secretory granules, tryptase is stored in complex with negatively charged heparin proteoglycans and it is known that heparin is essential for stabilizing
Melo, Fabio Rabelo, Christian P. Sommerhoff, Mirjana Grujic, Grujic, Mirjana, Sultan Alanazi, Maria Lampinen, Rollman, Ola, Pejler, Gunnar,, Grujic, Mirjana,, Rollman, Ola,, Fabio Rabelo Melo, Alanazi, Sultan,, Ola Rollman, Pejler, Gunnar, Lampinen, Maria,, Melo, Fabio Rabelo,, Sommerhoff, Christian P., Alanazi, Sultan, Lampinen, Maria, Gunnar Pejler, Sveriges lantbruksuniversitet., Sommerhoff, Christian P.,   +21 more
core   +2 more sources