Results 21 to 30 of about 21,184 (241)
Journal of Pharmacological Sciences, 2005 We found that striptease-positive mast cells were abundant in the invasive front of human colon adenocarcinoma by examining 30 cases. Because tryptase has been suggested to be the agonist proteinase for protease-activated receptor-2 (PAR-2), we ...
Masanori Yoshii +6 more
doaj +1 more source
Tryptase in type I hypersensitivity
, 2023 International audienceTryptase is currently the main mast cell biomarker available in medical practice. Tryptase determination is a quantitative test performed in serum or plasma for the diagnosis, stratification, and follow-up of mast cell–related ...
Klingebiel, Caroline +5 more
core +1 more source
Release of Mast Cell Tryptase into Saliva: A Tool to Diagnose Food Allergy by a Mucosal Challenge Test? [PDF]
, 2011 Background: Our aim was to examine whether measurement of the saliva mast cell tryptase (MCT) concentrations before and after a mucosal challenge test with the offending food would be helpful in diagnosing food allergy.
Franziska Ruëff +9 more
core +1 more source
Mast Cell beta-Tryptase Is Enzymatically Stabilized by DNA [PDF]
, 2020 Tryptase is a tetrameric serine protease located within the secretory granules of mast cells. In the secretory granules, tryptase is stored in complex with negatively charged heparin proteoglycans and it is known that heparin is essential for stabilizing
Melo, Fabio Rabelo +6 more
core +1 more source
Mast cell tryptase enhances wound healing by promoting migration in human bronchial epithelial cells
Cell Adhesion & Migration, 2021 Epithelial damage and increase of intraepithelial mast cells (MC) are characteristics of asthma. The role of MC mediator tryptase and the protease-activated receptor-2 (PAR2) on epithelial wound healing is not fully investigated. Stimulation of bronchial
Sofia Mogren +6 more
doaj +1 more source
Diagnostic Significance of Tryptase for Suspected Mast Cell Disorders
Diagnostics, 2023 Tryptase has proven to be a very useful and specific marker to demonstrate mast cell activation and degranulation when an acute (i.e., within 4 h after the event) and baseline value (i.e., at least 24 h after the event) are compared and meet the ...
Michiel Beyens +4 more
doaj +1 more source
Cells, 2023 Bronchial and alveolar remodeling and impaired epithelial function are characteristics of chronic respiratory diseases. In these patients, an increased number of mast cells (MCs) positive for serine proteases, tryptase and chymase, infiltrate the ...
Frida Berlin +7 more
doaj +1 more source
The role of heparin in the activation of mast cell tryptase [PDF]
, 2004 Mast cells play an important role in our immune defense against bacteria and parasites but are also key effector cells in various inflammatory diseases. They act by releasing inflammatory mediators from intracellular granules.
Hallgren, Jenny
core +1 more source
Mediators of Inflammation, 2013 Protease-activated receptor 2 (PAR-2), which is abundantly expressed in astrocytes, is known to play major roles in brain inflammation. However, the influence of the natural agonist of PAR-2, tryptase, on proinflammatory mediator releasedfrom astrocytes ...
Xiaoning Zeng +4 more
doaj +1 more source
Changes in tryptase levels during cardiac surgery in patients at low risk for allergic reactions
Medičnì Perspektivi, 2022 Tryptase test can be used as a clinical marker of mast cell activation. The present study is was aimed to identify variations in serum tryptase levels and their possible relationships with allergic reactions to protamine in low-risk patients undergoing ...
Menekse Oksar +5 more
doaj +1 more source