Results 41 to 50 of about 306,398 (210)

Mast Cells and Their Progenitors in Allergic Asthma

Frontiers in Immunology, 2019
Mast cells and their mediators have been implicated in the pathogenesis of asthma and allergy for decades. Allergic asthma is a complex chronic lung disease in which several different immune cells, genetic factors and environmental exposures influence ...
Erika Méndez-Enríquez, Jenny Hallgren
doaj   +1 more source

Comparative analysis of mast cell count in normal oral mucosa and oral pyogenic granuloma [PDF]

, 2011
Introduction: Mast cells are large granular cells that arise from a multipotent CD 34+ precursor in the bone marrow normally distributed throughout connective tissues.
Dahiya, Parveen, Kamal, Reet, Palaskar, Sangeeta, Shetty, V.P.   +3 more
core   +1 more source

Innate Immunity Induces the Accumulation of Lung Mast Cells During Influenza Infection

Frontiers in Immunology, 2018
Mast cells release disease-causing mediators and accumulate in the lung of asthmatics. The most common cause of exacerbations of asthma is respiratory virus infections such as influenza. Recently, we demonstrated that influenza infection in mice triggers
Behdad Zarnegar, Annika Westin, Syrmoula Evangelidou, Jenny Hallgren   +3 more
doaj   +1 more source

Future Needs in Mast Cell Biology. [PDF]

, 2019
The pathophysiological roles of mast cells are still not fully understood, over 140 years since their description by Paul Ehrlich in 1878. Initial studies have attempted to identify distinct "subpopulations" of mast cells based on a relatively small ...
de Paulis, Amato, Galli, Stephen J, Marone, Gianni, Varricchi, Gilda   +3 more
core   +2 more sources

Evidence for a novel Kit adhesion domain mediating human mast cell adhesion to structural airway cells [PDF]

, 2015
Background: Human lung mast cells (HLMCs) infiltrate the airway epithelium and airway smooth muscle (ASM) in asthmatic airways. The mechanism of HLMC adhesion to both cell types is only partly defined, and adhesion is not inhibited by function-blocking ...
A Ito, A Trautmann, CE Brightling, CE Brightling, CE Brightling, CT Mierke, D Sanmugalingam, D Smrz, EA Kabat, EP Moiseeva, F Hollins, J Sambrook, JM Blechman, KC Gough, KL Knight, M Popkov, MY Oh, NG Carroll, P Bradding, P Bradding, PO Girodet, SA Kuhne, SM Duffy, W Yang, Y Koma, Y Li, Y Shimizu   +26 more
core   +2 more sources

Mast Cell Proteoglycans [PDF]

Journal of Histochemistry & Cytochemistry, 2012
Mast cells are versatile effector cells of the immune system, contributing to both innate and adaptive immunity toward pathogens but also having profound detrimental activities in the context of inflammatory disease. A hallmark morphological feature of mast cells is their large content of cytoplasmic secretory granules, filled with numerous secretory ...
Elin, Rönnberg, Fabio R, Melo, Gunnar, Pejler   +2 more
openaire   +2 more sources

Increased expression of formyl peptide receptor-1 by basophils from patients with mastocytosis

Journal of Allergy and Clinical Immunology: Global
Background: Symptoms in patients with systemic mastocytosis (SM) are associated with an increase in mast cell burden and release of mast cell–derived mediators.
Yuzhi Yin, MD, PhD, Jenny Min Li, PhD, Dean D. Metcalfe, MD, Ana Olivera, PhD, Pamela A. Frischmeyer-Guerrerio, MD, PhD, Melody C. Carter, MD, Hirsh Komarow, MD   +6 more
doaj   +1 more source

Deletion of ΔdblGata motif leads to increased predisposition and severity of IgE-mediated food-induced anaphylaxis response.

PLoS ONE, 2019
BackgroundPrevious studies have revealed an important role for the transcription factor GATA-1 in mast cell maturation and degranulation. However, there have been conflicting reports with respect to the requirement of GATA-1 function in mast cell ...
Sribava Sharma, Sunil Tomar, Mayuri Dharne, Varsha Ganesan, Andrew Smith, Yanfen Yang, Lisa Waggoner, Yui-Hsi Wang, Simon P Hogan   +8 more
doaj   +1 more source

Rat embryonic mast cells originate in the AGM. [PDF]

PLoS ONE, 2013
Mast cells originate from pluripotent hematopoietic stem cells. Two mast cell specific antibodies, mAbsAA4 and BGD6, have previously been used to identify and study committed mast cell precursors (MCcps) in the bone marrow of adult mice and rats. However,
Michel Farchi Guiraldelli, Carolina Nunes França, Devandir Antonio de Souza, Elaine Zayas Marcelino da Silva, Vanina Danuza Toso, Celiane Cardoso Carvalho, Maria Célia Jamur, Constance Oliver   +7 more
doaj   +1 more source

Mast cell responses to danger signals [PDF]

, 2012
Detecting and responding to danger is a paramount function of the immune system. Compounds heralding danger can be divided into two groups: exogenous and endogenous danger signals.
Enoksson, Mattias
core   +1 more source