Results 41 to 50 of about 5,434,736 (260)

Release of TNF-α during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers [PDF]

, 2003
Objectives: Our study sought to elucidate the role of oxidative stress for shedding of tumor necrosis factor-α (TNF-α) and for activating TNF-α-converting enzyme (TACE).
Welsch, Ulrich, Sommerhoff, Christian P., Gilles, Stefanie, Zahler, Stefan, Becker, Bernhard F.   +4 more
core   +1 more source

The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells

, 2008
Activated mast cells are a major source of the eicosanoids PGD(2) and leukotriene C(4) (LTC(4)), which contribute to allergic responses. These eicosanoids are produced following the ERK1/2-dependent activation of cytosolic phospholipase A(2), thus ...
Hye Sun Kuehn, Gilfillan, Alasdair M., Michael A. Beaven, Alasdair M. Gilfillan, Kuehn, Hye Sun, Dean D. Metcalfe, Beaven, Michael A., Emily J. Swindle, Swindle, Emily J., Mi-Sun Kim, Kim, Mi-Sun, Metcalfe, Dean D.   +11 more
core   +2 more sources

Mast Cells and Their Progenitors in Allergic Asthma

Frontiers in Immunology, 2019
Mast cells and their mediators have been implicated in the pathogenesis of asthma and allergy for decades. Allergic asthma is a complex chronic lung disease in which several different immune cells, genetic factors and environmental exposures influence ...
Erika Méndez-Enríquez, Jenny Hallgren
doaj   +1 more source

Selective immunocapture reveals neoplastic human mast cells secrete distinct microvesicle‐ and exosome‐like populations of KIT‐containing extracellular vesicles

Journal of Extracellular Vesicles, 2022
Activating mutations in the receptor KIT promote the dysregulated proliferation of human mast cells (huMCs). The resulting neoplastic huMCs secrete extracellular vesicles (EVs) that can transfer oncogenic KIT among other cargo into recipient cells ...
Annika Pfeiffer, Jennifer D. Petersen, Guido H. Falduto, David Eric Anderson, Joshua Zimmerberg, Dean D. Metcalfe, Ana Olivera   +6 more
doaj   +1 more source

Pathways involved in gut mucosal barrier dysfunction induced in adult rats by maternal deprivation: corticotrophin-releasing factor and nerve growth factor interplay [PDF]

, 2007
Neonatal maternal deprivation (NMD) increases gut paracellular permeability (GPP) through mast cells and nerve growth factor (NGF), and modifies corticotrophin-releasing factor (CRF) and corticosterone levels.
Lionel Bueno, Ferrier, Laurent, Fioramonti, Jean, Mathilde Leveque, Cartier, Christel, Frederick Barreau, Raphael Moriez, Valerie Laroute, Laurent Ferrier, Andras Rosztoczy, Christel Cartier, Leveque, Mathilde, Rosztoczy, Andras, Jean Fioramonti, Barreau, Frederick, Laroute, Valerie, Moriez, Raphael, Bueno, Lionel, Leveque, M, Rosztoczy, A, Ferrier, L   +20 more
core   +1 more source

Induction of Mast Cell Accumulation by Tryptase via a Protease Activated Receptor-2 and ICAM-1 Dependent Mechanism

Mediators of Inflammation, 2016
Mast cells are primary effector cells of allergy, and recruitment of mast cells in involved tissue is one of the key events in allergic inflammation. Tryptase is the most abundant secretory product of mast cells, but little is known of its influence on ...
Xin Liu, Junling Wang, Huiyun Zhang, Mengmeng Zhan, Hanqiu Chen, Zeman Fang, Chiyan Xu, Huifang Chen, Shaoheng He   +8 more
doaj   +1 more source

Local lung responses following local lung challenge with recombinant lungworm antigen in systemically sensitized sheep [PDF]

, 2001
Chronic mast cell-mediated inflammation may contribute significantly towards the extensive tissue remodelling that is a feature of lungworm infection in ruminants.
C. J. Woodall, MacAldowie, CN, Kennedy, MW, C. N. MacAldowie, Woodall, CJ, Hodgson, C, Hodgson, C., Woodall, C J, C. Hodgson, Miller, H. R.P., Pemberton, AD, MacAldowie, C N, Miller, H R, Collie, D D, Collie, DDS, Pemberton, A D, D. D. S. Collie, Kennedy, M W, Miller, HRP, MacAldowie, C. N., Kennedy, M. W., Woodall, Chris J., N. McLean, McLean, N., M. W. Kennedy, Collie, D. D.S., McLean, N, Pemberton, A. D., H. R. P. Miller, A. D. Pemberton   +29 more
core   +1 more source

The role of mast cells in oral squamous cell carcinoma [PDF]

, 2017
The mast cells are initial effective lineage in both humoral and adaptive immunity. They are ubiquitous in skin, mucosa, and in function. They contain biologically essential and dynamic mediators in healthy and harmful conditions of tissue.
Raviteja Chitturi, Swetha Gudiseva, Arvind Babu Rajendra Santosh, Venkat Ramana Reddy Baddam, Chandrashekar Poosarla, Vamsikrishna Anumula   +5 more
core   +1 more source

Innate Immunity Induces the Accumulation of Lung Mast Cells During Influenza Infection

Frontiers in Immunology, 2018
Mast cells release disease-causing mediators and accumulate in the lung of asthmatics. The most common cause of exacerbations of asthma is respiratory virus infections such as influenza. Recently, we demonstrated that influenza infection in mice triggers
Behdad Zarnegar, Annika Westin, Syrmoula Evangelidou, Jenny Hallgren   +3 more
doaj   +1 more source

Increased expression of formyl peptide receptor-1 by basophils from patients with mastocytosis

Journal of Allergy and Clinical Immunology: Global
Background: Symptoms in patients with systemic mastocytosis (SM) are associated with an increase in mast cell burden and release of mast cell–derived mediators.
Yuzhi Yin, MD, PhD, Jenny Min Li, PhD, Dean D. Metcalfe, MD, Ana Olivera, PhD, Pamela A. Frischmeyer-Guerrerio, MD, PhD, Melody C. Carter, MD, Hirsh Komarow, MD   +6 more
doaj   +1 more source