Results 41 to 50 of about 172,226 (310)

Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells

Stem Cell Reports, 2018
Summary: Mast cells are tissue-resident immune cells. Their overgrowth/overactivation results in a range of common distressing, sometimes life-threatening disorders, including asthma, psoriasis, anaphylaxis, and mastocytosis. Currently, drug discovery is
Mari-Liis Kauts, Bianca De Leo, Carmen Rodríguez-Seoane, Roger Ronn, Fokion Glykofrydis, Antonio Maglitto, Polynikis Kaimakis, Margarita Basi, Helen Taylor, Lesley Forrester, Adam C. Wilkinson, Berthold Göttgens, Philippa Saunders, Elaine Dzierzak   +13 more
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Immunohistochemical Evaluation of Mast Cells in Leukoplakia and Oral Squamous Cell Carcinoma [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: More than 90% of oral cancers are squamous cell carcinomas with oral leukoplakia being the most common potentially malignant disorder.
Saranya Ramsridhar, Malathi Narasimhan
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Differential Diagnoses of Systemic Mastocytosis in Routinely Processed Bone Marrow Biopsy Specimens: A Review [PDF]

, 2010
Diagnosis of systemic mastocytosis (SM) is mainly based on the morphological demonstration of compact mast cell infiltrates in various tissue sites. In almost all patients such infiltrates are detected in the bone marrow.
Horny, H. -P., H.-P. Horny, Valent, P., P. Valent, Sotlar, K., K. Sotlar   +5 more
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Mast Cells and Their Progenitors in Allergic Asthma

Frontiers in Immunology, 2019
Mast cells and their mediators have been implicated in the pathogenesis of asthma and allergy for decades. Allergic asthma is a complex chronic lung disease in which several different immune cells, genetic factors and environmental exposures influence ...
Erika Méndez-Enríquez, Jenny Hallgren
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The role of mast cells in oral squamous cell carcinoma [PDF]

, 2017
The mast cells are initial effective lineage in both humoral and adaptive immunity. They are ubiquitous in skin, mucosa, and in function. They contain biologically essential and dynamic mediators in healthy and harmful conditions of tissue.
Raviteja Chitturi, Swetha Gudiseva, Arvind Babu Rajendra Santosh, Venkat Ramana Reddy Baddam, Chandrashekar Poosarla, Vamsikrishna Anumula   +5 more
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Induction of Mast Cell Accumulation by Tryptase via a Protease Activated Receptor-2 and ICAM-1 Dependent Mechanism

Mediators of Inflammation, 2016
Mast cells are primary effector cells of allergy, and recruitment of mast cells in involved tissue is one of the key events in allergic inflammation. Tryptase is the most abundant secretory product of mast cells, but little is known of its influence on ...
Xin Liu, Junling Wang, Huiyun Zhang, Mengmeng Zhan, Hanqiu Chen, Zeman Fang, Chiyan Xu, Huifang Chen, Shaoheng He   +8 more
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Involvement of Hypoxia-Inducible Factor-1 in the Inflammatory Responses of Human LAD2 Mast Cells and Basophils [PDF]

, 2012
We recently showed that hypoxia-inducible factor 1 (HIF-1) plays a crucial role in the pro-allergic functions of human basophils by transcriptional control of energy metabolism via glycolysis as well as directly triggering expression of the angiogenic ...
Claire L Streatfield, Sumbayev, Vadim V., Yasinska, Inna M., Gibbs, Bernhard F., Streatfield, Claire L., Vadim V Sumbayev, Oniku, Abraham E., Bernhard F Gibbs, Streatfield Claire L., Yasinska Inna, Sumbayev Vadim V., Inna Yasinska, Oniku Abraham E., Gibbs Bernhard F., Abraham E Oniku   +14 more
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KIT mutation analysis in mast cell neoplasms: recommendations of the European competence network on mastocytosis [PDF]

, 2015
Although acquired mutations in KIT are commonly detected in various categories of mastocytosis, the methodologies applied to detect and quantify the mutant type and allele burden in cells and various tissues are poorly defined.
T. Haferlach, Reiter, A., Sperr, W. R., Akin, C, Valent, P., C. Akin, Garcia-Montero, A., G. Hoermann, Broesby-Olsen, S, Triggiani, M, Escribano, L, Hartmann, K.., Kluin-Nelemans, H. C., Cross, N.C.P., J. Gotlib, A. Reiter, Hermine, O., Akin, C., K. Sotlar, Haferlach, T, S. Broesby Olsen, Hoermann, G., TRIGGIANI, MASSIMO, P. Valent, A. Garcia Montero, Metcalfe, D. D., Sperr, W R, Broesby-Olsen, S., Gotlib, J, Kristensen, T. K., Arock, M, N. C. P. Cross, Schwaab, J., M. Arock, K. Hartmann, Schwaab, J, Metcalfe, D D, Escribano, L., O. Hermine, Kluin-Nelemans, H.C., Hermine, O, W. R. Sperr, J. Schwaab, Hoermann, G, Triggiani, M., Metcalfe, D.D., Cross, N C P, Horny, H.-P., Kluin-Nelemans, H C, Sotlar, K., D. D. Metcalfe, Sperr, W.R., Horny, H-P, Valent, P, Orfao, A., P. Dubreuil, Reiter, A, T. K. Kristensen, Orfao, A, Dubreuil, P., A. Orfao, Gotlib, J., L. Escribano, Sotlar, K, Kristensen, T.K., Hartmann, K., Cross, N. C. P., Haferlach, T., Dubreuil, P, Kielsgaard Kristensen, Thomas, Arock, M., Garcia-Montero, A, H. C. Kluin Nelemans, H. P. Horny, Hartmann, K   +74 more
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Innate Immunity Induces the Accumulation of Lung Mast Cells During Influenza Infection

Frontiers in Immunology, 2018
Mast cells release disease-causing mediators and accumulate in the lung of asthmatics. The most common cause of exacerbations of asthma is respiratory virus infections such as influenza. Recently, we demonstrated that influenza infection in mice triggers
Behdad Zarnegar, Annika Westin, Syrmoula Evangelidou, Jenny Hallgren   +3 more
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Pathways involved in gut mucosal barrier dysfunction induced in adult rats by maternal deprivation: corticotrophin-releasing factor and nerve growth factor interplay [PDF]

, 2007
Neonatal maternal deprivation (NMD) increases gut paracellular permeability (GPP) through mast cells and nerve growth factor (NGF), and modifies corticotrophin-releasing factor (CRF) and corticosterone levels.
Lionel Bueno, Ferrier, Laurent, Fioramonti, Jean, Mathilde Leveque, Cartier, Christel, Frederick Barreau, Raphael Moriez, Valerie Laroute, Laurent Ferrier, Andras Rosztoczy, Christel Cartier, Leveque, Mathilde, Rosztoczy, Andras, Jean Fioramonti, Barreau, Frederick, Laroute, Valerie, Moriez, Raphael, Bueno, Lionel   +17 more
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