Results 11 to 20 of about 4,610,022 (310)
Current Gastroenterology Reports, 2010 Mast cells have been considered for many years to participate specifically in allergic reactions through the release of cytokines, chemokines, proteases, leukotrienes, and bioactive polyamines. Emerging roles for mast cells have been identified recently, which highlight their relevance in both innate and adaptive immunity.
Terez, Shea-Donohue +3 more
openaire +2 more sources
IgE Autoreactivity in Atopic Dermatitis: Paving the Road for Autoimmune Diseases?
Antibodies, 2020 Atopic dermatitis (AD) is a common skin disease affecting 20% of the population beginning usually before one year of age. It is associated with the emergence of allergen-specific IgE, but also with autoreactive IgE, whose function remain elusive.
Christophe Pellefigues
doaj +1 more source
Semaphorin-3 Promotes Specific Immunotherapy Effects on Experimental Food Allergy
Journal of Immunology Research, 2022 Sustaining higher frequency of mast cells in the allergic lesion site has been recognized. Factors causing high numbers of mast cells in the local tissues are not fully understood yet.
Huang Huang +11 more
doaj +1 more source
Regulation of osteoclastogenesis by mast cell in rheumatoid arthritis
Arthritis Research & Therapy, 2021 Background In the pathogenesis of rheumatoid arthritis (RA), the role of mast cells has not been revealed clearly. We aimed to define the inflammatory and tissue-destructive roles of mast cells in rheumatoid arthritis (RA).
Kyoung-Woon Kim +6 more
doaj +1 more source
Mast Cells: A New Frontier for Cancer Immunotherapy
Cells, 2021 Mast cells are unique tissue-resident immune cells of the myeloid lineage that have long been implicated in the pathogenesis of allergic and autoimmune disorders. More recently, mast cells have been recognized as key orchestrators of anti-tumor immunity,
Jake N. Lichterman, Sangeetha M. Reddy
doaj +1 more source
Functional and Phenotypic Characterization of Siglec-6 on Human Mast Cells
Cells, 2022 Mast cells are tissue-resident cells that contribute to allergic diseases, among others, due to excessive or inappropriate cellular activation and degranulation. Therapeutic approaches to modulate mast cell activation are urgently needed.
Piper A. Robida +15 more
doaj +1 more source
Mast cell-mediated immune regulation in health and disease
Frontiers in Medicine, 2023 Mast cells are important components of the immune system, and they perform pro-inflammatory as well as anti-inflammatory roles in the complex process of immune regulation in health and disease.
Kottarappat N. Dileepan +8 more
doaj +1 more source
The dark side of mast cells and their role in metastasis [PDF]
, 2014 Komarowska Marta Diana, Korakiewicz Gabriela, Pilaszewicz Agata, Hermanowicz Adam, Reszec Joanna, Debek Wojciech, Chyczewski Lech. The dark side of mast cells and their role in metastasis. Journal of Health Sciences. 2014;4(14):273-284. ISSN 1429-9623 /
Korakiewicz, Gabriela +6 more
core +1 more source
The mast cell and mast cell disease
Journal of the American Academy of Dermatology, 1995 Mast cell disease or mastocytosis is a heterogeneous group of clinical disorders characterized by the proliferation and accumulation of mast cells in a variety of tissues, most often the skin. The signs and symptoms of mast cell disease are varied, dependent on the localization of mast cells in different organs and the local and systemic effects of ...
J, Longley, T P, Duffy, S, Kohn
openaire +2 more sources
PI3Kγ adapter subunits in mast cells [PDF]
, 2009 The incidence of allergy and related diseases such as asthma increased rapidly over the last century, especially in western societies. The allergic symptoms impair the quality of life of patients and can even be life threatening.
Bohnacker, Thomas
core +1 more source