Results 11 to 20 of about 148,300 (268)
Mast cell-mediated immune regulation in health and disease
Frontiers in Medicine, 2023 Mast cells are important components of the immune system, and they perform pro-inflammatory as well as anti-inflammatory roles in the complex process of immune regulation in health and disease.
Kottarappat N. Dileepan +8 more
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Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells
Stem Cell Reports, 2018 Summary: Mast cells are tissue-resident immune cells. Their overgrowth/overactivation results in a range of common distressing, sometimes life-threatening disorders, including asthma, psoriasis, anaphylaxis, and mastocytosis. Currently, drug discovery is
Mari-Liis Kauts +13 more
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Harnessing the Power of Mast Cells in unconventional Immunotherapy Strategies and Vaccine Adjuvants
Cells, 2020 Mast cells are long-lived, granular, myeloid-derived leukocytes that have significant protective and repair functions in tissues. Mast cells sense disruptions in the local microenvironment and are first responders to physical, chemical and biological ...
Steven Willows, Marianna Kulka
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Cell Communication and Signaling, 2018 Background Mast cells may activate fibroblasts and contribute to remodeling processes in the lung. However, the mechanism behind these actions needs to be further investigated. Fibroblasts are major regulators of on-going remodeling processes.
Mariam Bagher +5 more
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Local Mast Cell Activation Promotes Neovascularization
Cells, 2020 Mast cells have been associated with arteriogenesis and collateral formation. In advanced human atherosclerotic plaques, mast cells have been shown to colocalize with plaque neovessels, and mast cells have also been associated with tumor vascularization.
Ilze Bot +6 more
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Brazilian Journal of Medical and Biological Research, 2023 As an important component of solid tumors, mast cells show specific phenotypes in various tumor microenvironments. However, the precise mechanism of mast cell accumulation and the phenotypic features of thyroid cancer (TC) remain largely unknown.
Yanli Hou +5 more
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Perivascular mast cells regulate vein graft neointimal formation and remodeling [PDF]
PeerJ, 2015 Objective. Emerging evidence suggests an important role for mast cells in vein graft failure. This study addressed the hypothesis that perivascular mast cells regulate in situ vascular inflammatory and proliferative responses and subsequent vein graft ...
Junxi Wu +9 more
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Toxins, 2016 The association of colitis with colorectal cancer has become increasingly clear with mast cells being identified as important inflammatory cells in the process.
Shan Wang +7 more
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JCI Insight, 2021 Ozone is a highly reactive environmental pollutant with well-recognized adverse effects on lung health. Bronchial hyperresponsiveness (BHR) is one consequence of ozone exposure, particularly for individuals with underlying lung disease.
Xiaomei Kong +18 more
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Isolation and Culture of Bone Marrow-derived Mast Cells
Bio-Protocol, 2014 The generation of mast cells for in vitro studies comes from a variety of sources including mast cell lines (MC/9) (McCurdy et al., 2001), bone marrow-derived mast cells (BMMCs) (Supajatura et al., 2001), skin-derived mast cells (FSMCs) (Matsushima et al.
Krisztina Vukman +3 more
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