Results 31 to 40 of about 4,610,022 (310)
Isolation and Culture of Peritoneal Cell-derived Mast Cells
Bio-Protocol, 2014 The generation of mast cells for in vitro studies comes from a variety of sources including mast cell lines (MC/9) (McCurdy et al., 2001), bone marrow-derived mast cells (BMMCs) (Supajatura et al., 2001), skin-derived mast cells (FSMCs) (Matsushima et al.
Krisztina Vukman +3 more
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JCI Insight, 2021 Ozone is a highly reactive environmental pollutant with well-recognized adverse effects on lung health. Bronchial hyperresponsiveness (BHR) is one consequence of ozone exposure, particularly for individuals with underlying lung disease.
Xiaomei Kong +18 more
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MiR-146a: a key microRNA involved in regulating mast cell survival and T lymphocyte differentiation [PDF]
, 2013 Mast cells are long-lived, tissue-resident cells of the innate immune system. Since the identification of mechanisms that regulate mast cell proliferation, survival and overall homeostasis in the tissues may have important implications for the treatment ...
Rusca, Nicole-Lily
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Journal for ImmunoTherapy of Cancer, 2019 Background Mast cells are prominent components of solid tumors and exhibit distinct phenotypes in different tumor microenvironments. However, the nature, regulation, function, and clinical relevance of mast cells in human gastric cancer (GC) are ...
Yipin Lv +18 more
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Involvement of Hypoxia-Inducible Factor-1 in the Inflammatory Responses of Human LAD2 Mast Cells and Basophils [PDF]
, 2012 We recently showed that hypoxia-inducible factor 1 (HIF-1) plays a crucial role in the pro-allergic functions of human basophils by transcriptional control of energy metabolism via glycolysis as well as directly triggering expression of the angiogenic ...
Claire L Streatfield +14 more
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Isolation and Culture of Bone Marrow-derived Mast Cells
Bio-Protocol, 2014 The generation of mast cells for in vitro studies comes from a variety of sources including mast cell lines (MC/9) (McCurdy et al., 2001), bone marrow-derived mast cells (BMMCs) (Supajatura et al., 2001), skin-derived mast cells (FSMCs) (Matsushima et al.
Krisztina Vukman +3 more
doaj +1 more source
Perivascular mast cells regulate vein graft neointimal formation and remodeling [PDF]
PeerJ, 2015 Objective. Emerging evidence suggests an important role for mast cells in vein graft failure. This study addressed the hypothesis that perivascular mast cells regulate in situ vascular inflammatory and proliferative responses and subsequent vein graft ...
Junxi Wu +9 more
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Non-canonical activation of PI3Kγ by Ca²⁺/PKCβ in mast cells [PDF]
, 2014 Mast cells are key effector cells in allergic disease triggering inflammation through mediator release. Allergens activate mast cells through the high-affinity receptor for IgE (FcεRI), which initiates signalling pathways that regulate the release of
Walser, Romy
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Interleukin-33 and Mast Cells Bridge Innate and Adaptive Immunity: From the Allergologist’s Perspective [PDF]
International Neurourology Journal, 2015 Interleukin (IL) 33, a member of the IL-1 superfamily, is an “alarmin” protein and is secreted in its active form from damaged cells undergoing necrotic cell death. Mast cells are one of the main effector cell types in allergic disorders.
Tae Young Jang, Young Hyo Kim
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Role of phosphoinositide 3-kinases in mast cell activation [PDF]
, 2009 Mast cells are primary effector cells in allergy and chronic inflammation. Class IB (PI3Kγ) and class IA (PI3Kδ) PI3K have been shown to play major roles in mast cell activation: antigen/IgE stimulation triggers autocrine/paracrine activation of mast ...
Collmann, Emilie
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