Results 51 to 60 of about 294,471 (310)

Mechanically Spatio‐Chimeric Fibrin Assembly Enables Vascular‐Integrated Muscle Reconstruction for Volumetric Muscle Loss Repair

Advanced Materials, EarlyView.
SPARC (spatio‐chimeric, plasma‐based, anisotropic, and shear‐responsive construct) that integrates myogenic and vascular microenvironments within a single construct. The dual‐modulus matrix directs aligned myotube formation and endothelial network development, enabling a vascularized muscle implant that seamlessly anastomoses with host tissue and ...
Su Hyun Jung, Minjun Kim, Da‐Yoon Kim, Min Kyu Kim, Sieun Lee, Yoonhee Jin, Joo H. Kang   +6 more
wiley   +1 more source

Analysis of human lung mast cells by single cell RNA sequencing

Frontiers in Immunology, 2023
Mast cells are tissue-resident cells playing major roles in homeostasis and disease conditions. Lung mast cells are particularly important in airway inflammatory diseases such as asthma.
Elin Rönnberg, Avinash Ravindran, Avinash Ravindran, Luca Mazzurana, Yitao Gong, Jesper Säfholm, Julie Lorent, Olga Dethlefsen, Ann-Charlotte Orre, Mamdoh Al-Ameri, Mikael Adner, Sven-Erik Dahlén, Joakim S. Dahlin, Jenny Mjösberg, Gunnar Nilsson, Gunnar Nilsson   +15 more
doaj   +1 more source

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

MODULATING THE INNATE IMMUNE RESPONSE TO ELECTROSPUN SCAFFOLDS AND POLYMER DEGRADATIVE BYPRODUCTS [PDF]

, 2017
Implanted biomaterials often induce inflammation that frequently leads to the foreign body response, fibrosis, and the failure of the implant. Thus, it is important to evaluate how cells interact with materials to promote a more regenerative response. It
Abebayehu, Daniel
core   +2 more sources

Evidence for a novel Kit adhesion domain mediating human mast cell adhesion to structural airway cells [PDF]

, 2015
Background: Human lung mast cells (HLMCs) infiltrate the airway epithelium and airway smooth muscle (ASM) in asthmatic airways. The mechanism of HLMC adhesion to both cell types is only partly defined, and adhesion is not inhibited by function-blocking ...
A Ito, A Trautmann, CE Brightling, CE Brightling, CE Brightling, CT Mierke, D Sanmugalingam, D Smrz, EA Kabat, EP Moiseeva, F Hollins, J Sambrook, JM Blechman, KC Gough, KL Knight, M Popkov, MY Oh, NG Carroll, P Bradding, P Bradding, PO Girodet, SA Kuhne, SM Duffy, W Yang, Y Koma, Y Li, Y Shimizu   +26 more
core   +2 more sources

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Mucosal Mast Cells Response in the Jejunum of Ascaridia Galli-Infected Laying Hens [PDF]

, 2013
Intestinal defense mechanism against helminthes parasitic nematode to be associated with mucosal mast cells reaction. The aim of this research was to examine the effect of infection by Ascaridia galli parasite to trigger mucosal defense based on mucosal ...
Balqis, U. (U), Darmawi, D. (Darmawi), Frengki, F. (Frengki), Hambal, M. (M), Priosoeryanto, B. P. (B)   +4 more
core  

The role of mast cells in the pathogenesis of pain in chronic pancreatitis [PDF]

, 2005
Background The biological basis of pain in chronic pancreatitis is poorly understood. Mast cells have been implicated in the pathogenesis of pain in other conditions. We hypothesized that mast cells play a role in the pain of chronic pancreatitis.
Willemijntje A Hoogerwerf, Kelly Gondesen, Shu-Yuan Xiao, John H Winston, William D Willis, Pankaj J Pasricha, EP Dimagno, H Friess, JM Braganza, I Esposito, TC Theoharides, G Barbara, RH Stead, RH Stead, A Elbadawi, R Suzuki, N Mori, X Ferry, V Puig-Divi, JM Laird, JH Winston, J Tito, B Etemad, LP Vera-Portocarrero, XQ Shu, YH Zhang, SD Skaper, M Theodosiou, F Florenzano, RS Nicholas, M Koltzenburg, HH Chuang, DD Metcalfe, DE Reed, C Gao, K Tamura, LW Fu, S Liu, WA Hoogerwerf, WA Hoogerwerf, T Hirata   +40 more
core   +1 more source

Skin Mast Cells Contribute to Sporothrix schenckii Infection [PDF]

, 2020
Background: Sporothrix schenckii (S. schenckii), a dimorphic fungus, causes sporotrichosis. Mast cells (MCs) have been described to be involved in skin fungal infections. The role of MCs in cutaneous sporotrichosis remains largely unknown. Objectives:
Frischbutter, Stefan, Geng, Peng, Jiao, Qingqing, Li, Ruoyu, Luo, Ying, Maurer, Marcus, Scheffel, Jörg, Wang, Yuhan, Zhao, Zuotao   +8 more
core   +1 more source

Beyond CD30: Dual‐Targeting of Malignant and Regulatory T Cells by Brentuximab Vedotin Remodels the Lymphoma Microenvironment and Overcomes Resistance via BCL2 Inhibition in Mycosis Fungoides

Advanced Science, EarlyView.
Single‐cell RNA analyses of paired lesions from CD30+ mycosis fungoides patients demonstrate that brentuximab vedotin (BV) induces immunogenic cell death in both CD30+ and CD30− malignant T cells. BV also targets regulatory T cells and remodels tumor microenvironment, while resistance is driven by impaired IFN responses, drug efflux, and BCL2 ...
Yi Jiang, Pan Lai, Mingjia Li, Yujie Wen, Mengzhou Cao, Yu Xiao, Zhuojing Chen, Jingru Sun, Yang Wang   +8 more
wiley   +1 more source