Results 61 to 70 of about 294,471 (310)

Asthma and Mast Cell Biology

European Journal of Inflammation, 2014
Asthma is a chronic inflammatory disease of the lung and its pathophysiology is initiated by mast cell activation in response to the antigen binding to IgE receptor as well as by TH2 cell activation.
S.K. Kritas, A. Saggini, G. Cerulli, A. Speziali, A. Caraffa, P. Antinolfi, A. Pantalone, M. Rosati, M. Tei, R. Saggini, P. Conti   +10 more
doaj   +1 more source

Orai and TRPC channel characterization in FcεRI-mediated calcium signaling and mediator secretion in human mast cells. [PDF]

, 2017
Inappropriate activation of mast cells via the FcεRI receptor leads to the release of inflammatory mediators and symptoms of allergic disease. Calcium influx is a critical regulator of mast cell signaling and is required for exocytosis of preformed ...
Alfonso, Alicia, Ashmole, Ashmole, Baba, Bischoff, Capite, Cayouette, Cayouette, Chaudhuri, Chen, Cheng, Cohen, Cruse, Derler, Dietrich, Douglas, Ennis, Estacion, Gilfillan, Gilfillan, Gordon, Hofmann, Hogan, Holowka, Hong, Kirshenbaum, Klein, Kuehn, Lee, Lewis, Liao, Liao, Liou, Ma, Martin-Avila, Medic, Metcalfe, Monet, Okayama, Ong, Ong, Ong, Pani, Pani, Prakriya, Prakriya, Pullen, Riazanski, Rice, Sabatino, Sanmugalingam, Seo, Shi, Siraganian, Souza, Souza, Storch, Suzuki, Vig, Vig, Wareham, Wareham, Washburn, Worley, Wykes, Yeh, Yuan, Zeng   +68 more
core   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Immunoprofiling Reveals Novel Mast Cell Receptors and the Continuous Nature of Human Lung Mast Cell Heterogeneity

Frontiers in Immunology, 2022
BackgroundImmunohistochemical analysis of granule-associated proteases has revealed that human lung mast cells constitute a heterogeneous population of cells, with distinct subpopulations identified.
Elin Rönnberg, Elin Rönnberg, Daryl Zhong Hao Boey, Daryl Zhong Hao Boey, Avinash Ravindran, Avinash Ravindran, Jesper Säfholm, Jesper Säfholm, Ann-Charlotte Orre, Mamdoh Al-Ameri, Mikael Adner, Mikael Adner, Sven-Erik Dahlén, Sven-Erik Dahlén, Joakim S. Dahlin, Joakim S. Dahlin, Gunnar Nilsson, Gunnar Nilsson, Gunnar Nilsson   +18 more
doaj   +1 more source

Stains Induce Apoptosis and Autophagy in Primary and Transformed Mast Cells [PDF]

, 2016
Statin drugs are widely employed in the clinic to reduce serum low density lipoproteins (LDLs) in patients with hypocholesteremia. In addition to their cholesterol-lowering effects through HMG CoA reductase antagonism, isoprenyl lipids necessary for ...
Paez, Patrick A
core   +1 more source

Rituximab modulates IL-17 expression in the salivary glands of patients with primary Sjögren's syndrome [PDF]

, 2014
OBJECTIVE: The aim of this study was to evaluate the role of rituximab (RTX) in modulating the expression of the IL-17/IL-23 pathway in the salivary glands (SGs) of patients with primary SS (pSS). METHODS: Consecutive SG biopsies were obtained
Alessandra Cannizzaro, Alunno, Angelo Ferrante, AnnaRita Giardina, Appel, Aroldo Rizzo, Cho, Ciccia, Ciccia, Ciccia, Dudeck, Francesco Carubbi, Francesco Ciccia, Giovanni Triolo, Giuliana Guggino, Gottenberg, Hueber, Hupp, Katsifis, Kenna, Meiners, Nguyen, Nguyen, Noordenbos, Paola Cipriani, Piconese, Pijpe, Riccardo Alessandro, Roberto Giacomelli, Sakai, Silverman, van de Veerdonk, Vitali, Voulgarelis, Yapici   +34 more
core   +1 more source

Hypofractionated Radiotherapy Induces ISG15+MHC‐I+ Neutrophils to Augment Anti‐Tumor Immunity and Prime Immune Checkpoint Blockade Responses in Rectal Cancer

Advanced Science, EarlyView.
ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu, Haihong Wang, Mingjie Li, Qian Xu, Linlin Zheng, Chaoqun Han, Zhenwei Zou, Jinghua Ren, Xiaorong Dong, Peng Zhang, Kaixiong Tao, Zhenyu Lin, Tao Zhang   +12 more
wiley   +1 more source

Interplay between mast cells, enterochromaffin cells, and sensory signaling in the aging human bowel. [PDF]

, 2009
BACKGROUND: Advanced age is associated with a reduction in clinical visceral pain perception. However, the underlying mechanisms remain largely unknown.
Firth, Saffrey, Lasch, Lagier, Gururatsakul, Santer, Gabella, El-Salhy, Souza, Phillips, Keating, Lee, Cremon, Barbara, Leri, Drossman, Camilleri, Fioramonti, Schwetz, Lindstrom, Jiang, Lynn, Brierley, Feng, Brookes, Brierley, Brierley, Bernard, Phillips, Phillips, Vega, Peck, Bergman, Csiszar, Giunta, Magrone, Stead, Stead, Naukkarinen, Pang, Wheatcroft   +40 more
core   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Prognostic significance of tumor microenvironment assessed by machine learning algorithm in surgically resected non‐small cell lung cancer

Cancer Reports, EarlyView., 2023
Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada, Mitsuhiro Isaka, Akira Ono, Takuya Kawata, Masakuni Serizawa, Keita Mori, Koji Muramatsu, Kiyoshi Tone, Hirotsugu Kenmotsu, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima, Masatoshi Kusuhara, Yasuto Akiyama, Takashi Sugino, Toshiaki Takahashi, Yasuhisa Ohde   +16 more
wiley   +1 more source