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Bronchodilating effect of KC-404, a novel anti-asthmatic agent, and its derivatives in monkey.

Archives internationales de pharmacodynamie et de therapie, 1987
The inhibitory effect of 3-isobutyryl-2-isopropylpyrazolo[1,5-alpha]pyridine (KC-404) on aerosolized methacholine- and histamine-induced increase in total respiratory resistance (Rrs) was determined in monkeys using the forced 3 Hz oscillation method and was compared with the effect of aminophylline.
S, Mue   +7 more
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Effect of the anti-asthmatic agent KC-404 on the contractile responses of rabbit airway smooth muscle to tachykinins.

Arerugi = [Allergy], 1990
To characterize the antagonistic action of KC-404, an anti-asthmatic agent, against the tachykinin-mediated bronchoconstriction, we studied the effect of this drug on the contractile responses of rabbit tracheal smooth muscle to neurokinin A (NKA) and substance P (SP) under isometric conditions in vitro.
J, Tamaoki   +4 more
openaire   +1 more source

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