Results 201 to 210 of about 638,178 (299)

Breaking biofilm barriers in skin wounds: Membrane-Active antimicrobials in an era of resistance. [PDF]

Curr Res Pharmacol Drug Discov
Hemmingsen LM, Škalko-Basnet N.
europepmc   +1 more source

Investigations of Novel Mechanisms of Action for Anti-Bacterial and Anti-Cancer Agent Development

, 2014
Jenson Verghese
openalex   +2 more sources

Vm–MSI: a Vancomycin–Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum

Advanced Science, EarlyView.
A series of vancomycin‐antimicrobial peptide conjugates is synthesized and evaluated to identify the optimal combination. Vm‐MSI, selected from multiple candidates, exhibited potent activity against vancomycin‐resistant and Gram‐negative bacteria by disrupting membranes and inducing oxidative stress, thereby expanding vancomycin's antibacterial ...
Shuangyu Li, Kang Wang, Wenzhuang Shi, Xu Wang, Duxin Li, Yanli Liu, Peng Zhang, Yipeng Wang   +7 more
wiley   +1 more source

Proactive Strategies to Prevent Biofilm-Associated Infections: From Mechanistic Insights to Clinical Translation. [PDF]

Microorganisms
Hernández-Huerta MT, Pérez-Campos E, Pérez-Campos Mayoral L, Vásquez Martínez IP, Reyna González W, Jarquín González EE, Aldossary H, Alhabib I, Yamani LZ, Elhadi N, Al-Suhaimi E, Cabrera-Fuentes HA.   +11 more
europepmc   +1 more source

DRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut

Advanced Science, EarlyView.
Dopamine receptor D2 (DRD2) deficiency disrupts epithelial barrier integrity in both the gut and pituitary gland, facilitating translocation of gut‐derived Escherichia coli into pituitary tissue. Intratumoral E. coli are phagocytosed by microglia, triggering GSDMD‐dependent pyroptosis and HMGB1 release, which subsequently activates MAPK signaling to ...
Xian‐jun Su, Li Ma, Xi Xiong, Jun‐hua Meng, Qi Wu, Yu Zhang, Shu‐guang Dong, Yue‐fei Wang, Jin‐hu Wu, Qing‐yuan Zeng, Hong‐feng Zhang, Li‐li Li, Liang Meng, Min Peng, Xiao‐dong Huang, Li‐quan Wu, Xiong Wang   +16 more
wiley   +1 more source

Simulated endocardial vegetation model highlights the complexity of high-inoculum infections among β-lactamase-producing organisms. [PDF]

Antimicrob Agents Chemother
Fratoni AJ.
europepmc   +1 more source

[Preventive use of anti-bacterial agents].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1974
openaire   +1 more source

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling

Advanced Science, EarlyView.
ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li, Chen Wu, Yuqi Zhu, Zicheng Liu, Wenjuan Yu, Andrew Lukwaro, Yu Zhong, Guoqiang Xie, Lili Zhou, Xiaoru Huang, Hui‐yao Lan, Junzhe Chen, Ying Tang   +12 more
wiley   +1 more source

Engineering bacteria for enhanced tumor therapy: from surface modification to synthetic genetic circuits. [PDF]

J Hematol Oncol
Wang Y, Xiao S, Yu W, Han B, Guo G.
europepmc   +1 more source

Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF‐β1

Advanced Science, EarlyView.
RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng, Lulu Zhang, Yimeng Fan, Sijuan Huang, Qingyu Zhao, Chao Han, Zhihui Hao   +6 more
wiley   +1 more source