Results 111 to 120 of about 1,620,652 (307)

Targeting Golgi–STING Signaling to Reprogram Innate and Adaptive Immunity for the Treatment of Implant‐Associated Infections

Advanced Science, EarlyView.
This study presents an ultrasound‐responsive nanoplatform, CS‐BT@MZ@NEs, with a BaTiO3/Mn‐Zif‐8 core and a chondroitin sulfate coating for Golgi targeting. By leveraging neutrophil hitchhiking, it enables targeted delivery to infection sites. Under ultrasound stimulation, CS‐BT@MZ@NEs generates ROS and modulates Golgi pH to activate cGAS–STING ...
Shicheng Huo, Naifeng Zhu, Zhuocheng Lyu, Yifei Liu, Zhenjiang Xu, Chun Zhou, Yaochao Zhao, Changgui Shi   +7 more
wiley   +1 more source

Pentacyclic Triterpenoid Acids Inhibit the Expression of Quorum Sensing-Related Virulence Factors and the Formation of Biofilm in Pseudomonas aeruginosa PAO1

Antibiotics
Background/Objectives: Numerous natural compounds have been reported to exhibit anti-virulence properties against pathogenic bacteria. Particularly, plants constitute a rich source of anti-quorum-sensing (QS) and anti-biofilm compounds with highly ...
Tsiry Rasamiravaka, Adeline Mol, Pierre Duez, Mondher El Jaziri, Marie Baucher   +4 more
doaj   +1 more source

Processi molecolari coinvolti nell'attività anti-biofilm: approccio proteomico multi-strategico

, 2014
Lo sviluppo e la funzionalità di un nuovo materiale antibiofilm non può prescindere dalla comprensione dei meccanismi molecolari che permettono alle molecole che lo compongono di impedire la formazione di un biofilm microbico.
S. Baroni, C. Cattò, F. Forlani
core  

Microblasting Wound Dressings Mechanically Disrupt Polymicrobial Biofilms to Enhance Healing in Treatment‐Resistant Wounds

Advanced Science, EarlyView.
Treatment‐resistant wounds caused by polymicrobial biofilms are refractory to conventional therapies due to the dense extracellular matrices. We developed μBLAST, a microblasting wound dressing that combines MnO2‐doped biosilica and a H2O2‐releasing mesh to generate localized oxygen microbubbles that mechanically disrupt biofilms.
Yujin Ahn, Joo Hun Lee, Christian Hurd, Jiye Lee, Junggeon Park, Adam A. Markowicz, Zheyuan Zhang, Joanne Hwang, Guillermo L. Monroy, Simon A. Rogers, Woonggyu Jung, Stephen A. Boppart, Hyunjoon Kong   +12 more
wiley   +1 more source

Anti-Candida Activity of Geraniol: Effect on Hydrolytic Enzyme Secretion and Biofilm Formation

, 2018
Existing antifungal drugs available today are low in efficacy, high in toxicity and cause multidrug resistance. Anti-Candida potential of geraniol, an acyclic monoterpene alcohol was evaluated and secretion of hydrolytic enzymes, adherence and biofilm ...
Khadija Al Fadel, Sumit Kumar Rastogi, Sahar Saadallah Amin Saadallah, Yamini Sharma, Nikhat Manzoor   +4 more
core   +1 more source

Biodegradable Zn‐Based Implants: Progress, Challenges, and Pathways toward Clinical Translation

Advanced Science, EarlyView.
Exploring biodegradable Zn‐based implants offers a promising pathway to next‐generation biomedical devices with balanced degradation and biocompatibility. A comprehensive overview of biodegradable Zn‐based implants, covering their biological significance, material design principles, and advanced engineering strategies is provided.
Panfeng Zhao, Zhengquan Wang, Hui Yang, Xiyuan Zhang, Hanyuan Liu, Xiaotong Lu, Xiaocheng Li, Yanyan Liu, Xi Zhao, Wenhao Zhou, Yufeng Zheng   +10 more
wiley   +1 more source

Eugenol inhibits quorum sensing and biofilm of toxigenic MRSA strains isolated from food handlers employed in Saudi Arabia

Biotechnology & Biotechnological Equipment, 2017
Food handlers are important component in assessment and maintenance of food quality as they are carriers of food pathogens causing spoilage. Food spoilage is attributed to quorum sensing (QS) controlled development of biofilms.
Nasser Abdulatif Al-Shabib, Fohad Mabood Husain, Iqbal Ahmad, Mohammad Hassan Baig   +3 more
doaj   +1 more source

Simulation studies of process scale membrane aerated biofilm reactor configurations

, 2013
4th International Water Association Membranes Conference, Harrogate, UK, January, 2007In the membrane aerated biofilm reactor oxygen diffuses through the membrane into the biofilm where oxidation of pollutants, supplied from the biofilm side of the ...
Casey, Eoin
core  

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Inside‐Outside ROS Therapeutic Strategy Based on Piezoelectric Nano‐Urchin for Drug‐Resistant Bacteria Biofilm Infections

Advanced Science, EarlyView.
The contribution of this study lies not only in enabling effective treatment of drug‐resistant biofilm infections, but also in establishing a transferable therapeutic paradigm: Ultrasound‐triggered mechanical forces synergistically enhance piezoelectric polarization and nanozyme activity, driving functional ROS generation inside and outside biofilms ...
Xinjian Guo, Jin Yang, Mengjie An, Bingjie Lin, Tao Liu, Limin Zhang   +5 more
wiley   +1 more source