Results 181 to 190 of about 64,578 (259)

Recent Advances (2023–2025) of Capillary Electrophoresis‐Mass Spectrometry (CE‐MS) for Top‐Down Proteomics

open access: yesMass Spectrometry Reviews, EarlyView.
ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu   +5 more
wiley   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

open access: yesMass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág   +5 more
wiley   +1 more source

Homocysteine and S-adenosyl-L-homocysteine impair development and methylation in yeast and flies. [PDF]

open access: yesDis Model Mech
Brunner MS   +12 more
europepmc   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Design, Analysis, and Experimental Validation of a Variable‐Gap Magnetorheological Damper for Seat Suspension

open access: yesInternational Journal of Mechanical System Dynamics, EarlyView.
ABSTRACT To address the dual challenges of routine driving vibration and impact loads in vehicle seat suspensions, a novel variable‐gap magnetorheological damper (VGMRD) is proposed. By combining a tapered piston with a conformal variable‐diameter cylinder, stroke‐dependent, dual‐mode damping characteristics are achieved without the need for complex ...
Min Wei   +4 more
wiley   +1 more source

Digital surveillance of animals and nature recovery

open access: yesPeople and Nature, EarlyView.
Abstract Digital surveillance technologies (DSTs) are widely applied in nature recovery for their potential to generate novel data on species and ecosystems through digital tracking, automation (e.g. from hazardous locations) and from newly recruited citizen scientists.
William M. Adams
wiley   +1 more source

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