Results 31 to 40 of about 67,371 (260)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

A Comparison of RFID Anti-Collision Protocols for Tag Identification

open access: yesApplied Sciences, 2018
Radio Frequency Identification (RFID) is a technology that uses radio frequency signals to identify objects. RFID is one of the key technologies used by the Internet of Things (IoT).
Nikola Cmiljanic   +2 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Beam Search Algorithm for Anti-Collision Trajectory Planning for Many-to-Many Encounter Situations with Autonomous Surface Vehicles

open access: yesSensors, 2020
A single anti-collision trajectory generation problem for an “own” vessel only is significantly different from the challenge of generating a whole set of safe trajectories for multi-surface vehicle encounter situations in the open sea.
Jolanta Koszelew   +5 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

A Machine Learning Auxiliary Approach for the Distributed Dense RFID Readers Arrangement Algorithm

open access: yesIEEE Access, 2020
This paper is an extended version of the work published. Radio-frequency identification (RFID) is widespread in industries such as supply-chain management and logistics due to its low-cost feature. In many real-world problems, one often needs to leverage
Peizhi Yan   +2 more
doaj   +1 more source

Ship Domain Model for Multi-ship Collision Avoidance Decision-making with COLREGs Based on Artificial Potential Field [PDF]

open access: yesTransNav, 2017
A multi-ship collision avoidance decision-making and path planning formulation is studied in a distributed way. This paper proposes a complete set of solutions for multi-ship collision avoidance in intelligent navigation, by using a top-to-bottom ...
TengFei Wang   +3 more
doaj   +1 more source

Research on the intelligent management system of the trackless rubber-tyred vehicles in the coal mine

open access: yesGong-kuang zidonghua, 2023
In the coal mine, underground working places are scattered, transportation routes are complex, and there are many bends and intersections in the roadway.
YANG Kun
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

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