Results 81 to 90 of about 800,280 (370)

Anti-crisis management of enterprise staff based on motivation

Actual problems of innovative economy and law
Introduction. In the current landscape, the prevalence of crisis phenomena has brought human resource management issues to the forefront at all levels.
Anton Melnyk, Oleksandr Petrenko
semanticscholar   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

MANAGEMENT OF ANTI-CRISIS MANAGEMENT OF ENTERPRISES

Market Infrastructure
The article considers different approaches to understanding financial planning, highlights its importance as a tool for reducing financial risks and ensuring the financial stability of the enterprise. Special attention is paid not only to profitability forecasting, but also to factors affecting solvency and capital structure. The article also describes
Olena Smetaniuk, Yuriy Karpinskyi
openaire   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

ANTI-CRISIS MANAGEMENT: A MODERN CONCEPT AND THE MAIN INSTRUMENTARIUM

Управленческие науки, 2015
The article investigates the main aims, values and the concept of anti-crisis management, as a new scientific direction; settles down the statement about the crisis as an inevitable stage of social and economic development of a system at any level ...
A. Ryakhovskaya, S. Kovan
doaj   +1 more source

Monitoring the state anti-crisis management of economic security of the Ukraine banking institutions

Business: Theory and Practice, 2020
The study and synthesis of research showed that the most often anti-crisis management is considered, firstly, as a complex of preventive measures that is comprehensive and aimed at preventing and eliminating unfavorable phenomenon for business using ...
Iryna Mihus, Yana Koval, Serhiy Laptev, Olha Bala, Marta Kopytko   +4 more
doaj   +1 more source

ОБҐРУНТУВАННЯ МЕХАНІЗМУ АНТИКРИЗОВОЇ ДЕРЖАВНОЇ ПОЛІТИКИ У ТУРИСТИЧНІЙ ГАЛУЗІ. (JUSTIFICATION OF THE MECHANISM OF ANTI-CRISIS STATE POLICY IN TOURISM). [PDF]

, 2014
У статті розкрито сутність і значення поняття «механізм» із погляду його застосування в економічній науці; визначено сутність антикризової державної політики; розкрито сутність наявних механізмів антикризового управління та регулювання; обґрунтовано ...
Маркіна, І. (I. Markina), Черниш, І. (I. Chernysh)   +1 more
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Anti-crisis Management of Hotel and Restaurant Business Enterprises as an Urgent Tool for Overcoming Unexpected Situations in Difficult Economic Conditions

Restaurant and hotel consulting. Innovations
Topicality. Caused by the world instability, changes in business conditions, economic connections with consumers and employees, transformational processes of socio-economic and political relations in Ukraine update and require flexibility and ...
Liudmyla Batchenko, Liliia Honchar, Valeriia Kovalenko   +2 more
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source