Results 31 to 40 of about 140,143 (264)

Fighting Discrimination through Sport? Evaluating Sport-Based Workshops in Irish Schools

Education Sciences, 2023
Discrimination based on ethnicity, gender, or sexual orientation remains a pressing challenge throughout Europe, including within Ireland. Despite this, anti-discrimination education is lacking and uneven within school settings.
Louis Moustakas, Lisa Kalina
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Queer sein ist (bibliotheks)politisch

Library Ideas
Seit November 2023 gibt es die Queerbrarians, ein deutschsprachiges Netzwerk queerer Bibliotheksmenschen. Anhand der beim ersten Treffen zusammengetragenen Themen legt dieser Beitrag neben den Beweggründen für die Entstehung des Netzwerks auch dessen ...
Claudia Frick, Philipp Zeuner, Caleb Buchert, Daniela Markus, Norma Fötsch, Yvonne Fischer, Emma Wieseler, Sabrina Ramünke, Nik Baumann   +8 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

School Students’ Intercultural Partnerships Contest Discrimination: A Case Study of Intersectional Social Change

Youth
Social inclusion of ethno-cultural minorities is a global concern which an acknowledged backlash against multiculturalism challenges. In Australia, some politicians and sections of the media have fuelled this backlash against refugee and minority culture
Fran Gale, Michel Edenborough, Susie Leeds   +2 more
doaj   +1 more source

Ethnic Minority Protection and Anti-discrimination in Central Europe Before and After EU Accession: the Case of Poland [PDF]

Journal on Ethnopolitics and Minority Issues in Europe, 2007
This article explores key policy developments regarding ethnic minority protection and anti-discrimination in contemporary Poland. More specifically, it examines the relationship between domestic policy formation and the European context.
Peter Vermeersch
doaj  

Implementation of anti-discrimination legislation in the sphere of labor [PDF]

Temida, 2014
The establishment of an anti-discrimination normative framework concluded with the adoption of Anti-discrimination Law in 2009. In the intervening five years since its implementation there has been various difficulties, doubts and ...
Reljanović Mario
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source